Importance of local production of endothelin-1 and of the ET(B) receptor in the regulation of pulmonary vascular tone

Pulmonary Pharmacology and Therapeutics

Volumn 13, Issue 3, 2000, Pages 135-140

  Dupuis, J ^a   Jasmin, J F ^a   Prie S ^a   Cernacek, P ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Endothelial receptors; Endothelins; Endothelium; Pulmonary circulation; Vasoactive agent

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; MONOCROTALINE; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; VASOACTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ISOLATED LUNG; LUNG CLEARANCE; LUNG PERFUSION; LUNG VASCULAR RESISTANCE; MALE; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM;

EID: 0033777972     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.2000.0242     Document Type: Article

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4. ET(A) and ET(B) receptors mediate contraction to endothelin-1 in renal artery of aging SHR. Effects of FR139317 and bosentan
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13. Altered expression of ET(B)-receptor mRNA in the lung of rats with pulmonary hypertension
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15. The orally active ET(A) receptor antagonist (+)-(S)-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionic acid (LU 135252) prevents the development of pulmonary hypertension and endothelial metabolic dysfunction in monocrotaline-treated rats
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