Subcellular distribution of CFTR in rat intestine supports a physiologic role for CFTR regulation by vesicle traffic

Histochemistry and Cell Biology

Volumn 114, Issue 3, 2000, Pages 219-228

  Ameen, Nadia A ^a,b   Van Donselaar, Elly ^c   Posthuma, George ^c   De Jonge, Hugo ^d   McLaughlin, Gwenn ^a   Geuze, Hans J ^c   Marino, Christopher ^b   Peters, Peter J ^c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UTRECHT UNIVERSITY   (Netherlands)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

CFTR; Intestine; Subcellular localization; Vesicle traffic

Indexed keywords

CYCLIC AMP; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANION TRANSPORT; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; INTESTINE; INTESTINE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; QUANTITATIVE ASSAY; RAT; REGULATORY MECHANISM; ULTRASTRUCTURE;

EID: 0033774314     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004180000167     Document Type: Article

References (36)

1. Distribution of chloride exit (CFTR) and entry (Na-K-Cl cotransporter) proteins in rat intestine
2. A unique subset of rat and human intestinal villus cells express the cystic fibrosis transmembrane conductance regulator
3. CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivo
4. Generation of cAMP-activated chloride currents by expression of CFTR
5. Role of membrane trafficking in plasma membrane solute transport
6. Biochemical and biophysical identification of the cystic fibrosis transmembrahe conductance regulator chloride channels as components of endocytic clathrin-coated vesicles
7. Characterization of the cystic fibrosis transmembrane conductance regulator in a colonocyte cell line
8. Localization of the cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia
9. Toxigenic diarrheas, congenital diarrheas and cystic fibrosis: Disorders of intestinal ion transport
10. A delta F508 mutation in mouse cystic fibrosis transmembrane conductance regulator results in a temperature-sensitive processing defect in vivo
11. Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model
12. Cellular localization of the cystic fibrosis transmembrane conductance regulator protein in piglet and mouse intestine
13. Model systems for studying cell fate specification and differentiation in the gut epithelium
14. Acid-stimulated duodenal bicarbonate secretion involves a CFTR-mediated transport pathway in mice
15. Immunological localization of cystic fibrosis candidate gene products
16. The biogenesis, traffic, and function of the cystic fibrosis transmembrane conductance regulator
17. The response of small intestinal villus and crypt epithelium to cholera toxin in rat and guinea pig. Evidence against a role of the crypt cells in choleragen-induced secretion
18. Delta F508 CFTR protein expression in tissues from patients with cystic fibrosis
19. Origin of cAMP-dependent C1 secretion from both crypts and surface epithelia of rat intestine
20. Vasoacrive intestinal peptide, forskolin, and genistein increase apical CFTR trafficking in the rectal gland of the spiny dogfish, Squalus acanthias. Acute regulation of CFTR trafficking in an intact epithelium
21. Improving structural integrity of cryosections for immunogold labeling
22. Distinct and specific functions of cGMP-dependent protein kinases
23. Localization of the cystic fibrosis transmembrane conductance regulator in pancreas
24. X-ray microanalysis of cell elements in normal and cystic fibrosis jejunum: Evidence for chloride secretion in villi
25. Cell surface labeling of CFTR in T84 cells
26. Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor
27. 3- secretion
28. A microelectrode study of responses to secretagogues by epithelial cells on villus and crypt of rat small intestine
29. Localization of the cystic fibrosis conductance regulator mRNA in the human gastrointestinal tract by in situ hybridization
30. CFTR-dependent membrane insertion is linked to stimulation of the CFTR chloride conductance
31. Apical recruitment of CFTR in T84 cells is dependent on cAMP and microtubules but not calcium or microfilaments
32. In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator
33. Subcellular localization of CFTR to endosomes in a ductal epithelium
34. Crypts are the site of intestinal fluid and electrolyte secretion
35. Immuno and functional characterization of CFTR in submandibular and pancreatic acinar and duct cells