Airway fibrosis in asthma: Mechanisms, consequences, and potential for therapeutic intervention

Monaldi Archives for Chest Disease

Volumn 55, Issue 4, 2000, Pages 317-323

  Redington, A E ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Asthma; Collagen; Fibroblast; Myofibroblast; Remodelling; Transforming growth factor beta

Indexed keywords

ANTIASTHMATIC AGENT; BECLOMETASONE DIPROPIONATE; BUDESONIDE; COLLAGEN; CORTICOSTEROID; FLUTICASONE PROPIONATE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; SALBUTAMOL; SALMETEROL; THEOPHYLLINE; TRANSFORMING GROWTH FACTOR BETA;

AIRWAY DYNAMICS; ASTHMA; CELL PROLIFERATION; CLINICAL TRIAL; DOSE TIME EFFECT RELATION; DRUG MECHANISM; EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; LUNG FIBROSIS; MYOFIBROBLAST; REVIEW;

EID: 0033772940     PISSN: 11220643     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Airway wall remodelling in asthma
2. The pathology of bronchial asthma
3. A clinical and pathological study of fatal cases of status asthmaticus
4. Death in asthmatics
5. Bronchial biopsies in asthma: An ultrastructural, quantitative study and correlation with hyperreactivity
6. Subepithelial fibrosis in the bronchi of asthmatics
7. Characteristics of the inflammation in biopsies from large airways of subjects with asthma and subjects with chronic airflow limitation
8. The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway
9. Immunopathology of the bronchial mucosa in 'late-onset' asthma
10. Airway mucosal inflammation in occupational asthma induced by toluene diisocyanate
11. The bronchial basement membrane in asthma
12. Ultrastructure of airways in children with asthma
13. Lower airways remodelling in nonasthmatic subjects with allergic rhinitis
14. Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid
15. Distribution of integrins αvβ6 and α9β1 and their known ligands, fibronectin and tenascin, in human airways
16. Eosinophil-associated TGF-β1 mRNA expression and airways fibrosis in bronchial asthma
17. Collagen deposition in large airways may not differentiate severe asthma from milder forms of the disease
18. Airway and lung elastic fibre is not reduced in asthma nor in asthmatics following corticosteroid treatment
19. Pathological changes according to the severity of asthma
20. Airways remodeling is a distinctive feature of asthma and is related to severity of disease
21. Expression of growth factors and remodelling of the airway wall in bronchial asthma
22. Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma
23. Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma
24. Role of bronchial basement membrane in airway collapse
25. Site and nature of airway obstruction in chronic obstructive lung disease
26. The mechanics of airway narrowing in asthma
27. Small airways dimensions in asthma and in chronic obstructive pulmonary disease
28. A model of the mechanics of airway narrowing
29. The lack of distensibility of asthmatic airways
30. Myofibroblast involvement in the allergen-induced late response in mild atopic asthma
31. Transforming growth factor-β expression in mucosal biopsies in asthma and chronic bronchitis
32. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
33. Contractile interstitial cells in pulmonary alveolar septa: Ultrastructural, immunofluorescence and in vitro studies: A possible regulation of ventilation perfusion ratio
34. Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins
35. Myofibroblasts and subepithelial fibrosis in bronchial asthma
36. α-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing
37. The transforming growth factor-β family
38. Transforming growth factor-β1 induces α-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
39. Transforming growth factor-beta 1 in asthma: Measurement in bronchoalveolar lavage fluid
40. Transforming growth factor β1 gene expression in human airways
41. Altered compartmentalization of transforming growth factor-β in asthmatic airways
42. Co-localization of immunoreactive transforming growth factor-beta 1 and decorin in bronchial biopsies from asthmatic and normal subjects
43. Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation
44. Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease
45. Slowing the deterioration of asthma and chronic obstructive pulmonary disease observed after bronchodilator therapy by adding inhaled corticosteroids
46. Effect of early vs late intervention with inhaled corticosteroids in asthma
47. Is delayed introduction of inhaled corticosteroids harmful in patients with obstructive airways disease (asthma and COPD)?
48. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: A quantitative light and electron microscopic study
49. Placebo-controlled immunopathologic study of four months on inhaled corticosteroids in asthma
50. Effect of short-term treatment with low-dose inhaled fluticasone propionate on airway inflammation and remodelling in mild asthma: A placebo-controlled study
51. The long-acting β2-agonist salmeterol xinafoate: Effects on airway inflammation in asthma
52. Regular albuterol or nedocromil sodium - Effects on airway subepithelial tenascin expression