Alteration in the organ distribution of iron by truncated transferrin: Implications for iron chelation therapy

Journal of Laboratory and Clinical Medicine

Volumn 130, Issue 3, 1997, Pages 271-277

  Li, Liangtao ^a   Kaplan, Jerry ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031239724     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2143(97)90021-4     Document Type: Article

References (19)

1. Harker LA, Funk DD, Finch CA. Evaluation of storage iron by chelates. Am J Med 1968;45:105-15.
2. Hofbrand AU. Iron in biochemistry and medicine. In: Jacobs A, Worwood A, editors. London: Academic Press, 1980:499-527.
3. Williams J, Grace SA, Williams JM. Evolutionary significance of the renal excretion of transferrin half-molecule fragments. Biochem J 1982;201:417-9.
4. Funk WD, MacGillivray RTA, Mason AB, Brown SA, Woodworth RC. Expression of the amino-terminal half molecule of human serum transferrin in cultured cells and characterization of the recombinant protein. Biochemistry 1990; 29:1654-60.
5. Zak O, Aisen P. Preparation of and properties of a single-sited fragment from the c-terminal domain of human transferrin. Biochem Biophys Acta 1985;829:348-53.
6. Ward JH, Kaplan J. Receptor assay with radiolabelled transferrin. Methods Enzymol 1987;147:247-52.
7. Makey DG, Seale US. The detection of four molecular forms of human transferrin during the iron binding process. Biochem Biophys Acta 1976;453:708-13.
8. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227: 680-5.
9. Burnette WN. Western blotting: electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein-A. Anal Biochem 1981; 112:195-203.
10. Lowry O, Rosebrough NF, Farr AG, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
11. Zavartink M, Thacher T, Rechsteiner M. Degradation of microinjected protein into cultured mammalian cells. J Cell Physiol 1979;100:175-86.
12. Craven CM, Alexander J, Kushner JP, Bernstein S, Kaplan J. Tissue distribution and clearance kinetics of non-transferrin bound iron in normal and hypotransferrinemic mice: a rodent model for hemochromatosis. Proc Natl Acad Sci USA 1987; 84:3457-61.
13. Lineback-Zins J, Brew K. Preparation and properties of an NH2-terminal peptide of human serum transferrin containing a single iron binding site. J Biol Chem 1980;255:708-13.
14. Zak O, Aisen P. Nonrandom distribution of iron in circulating human transferrin. Blood 1985;68:157-61.
15. Zak O, Trinder D, Aisen P. Primary recognition site of human transferrin is in the C-terminal lobe. J Biol Chem 1994;269:7110-4.
16. Peterson M, Kaplan J, Jorgensen C, Schmidt L, Li L, Morgan J, et al. Sustained production of human transferrin by transduced fibroblasts implanted into athymic mice: a model for somatic gene therapy. J Invest Dermatol 1994;104:171-6.
17. Alfrey AC, Hammond WS. Renal iron handling in the nephrotic syndrome. Kidney Int 1990;37:1409-13.
18. Sturrock A, Alexander JR, Lamb J, Craven CM, Kaplan J. Characterization of a transferrin independent uptake system for iron in cultured HeLa cells. J Biol Chem 1990;265:3139-45.
19. Rubin M, Pachtman E, Aidridge M, Zapolski EJ, Bagley DH, Princiotto JV. The metabolism of parenteral iron chelates. Biochem Med 1970;3:271-88.