Renal transfer of genetically engineered cells

Journal of the American Society of Nephrology

Volumn 11, Issue SUPPL. 16, 2000, Pages

  Kitamura, M ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; CELL INFILTRATION; GENE TRANSFER; GENETIC ENGINEERING; GLOMERULOPATHY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0033764493     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Strategic gene transfer into the kidney: Current status and prospects
2. Gene delivery into the glomerulus via mesangial cell vectors
3. Gene transfer into the rat renal glomerulus via a mesangial cell vector: Site-specific delivery, in situ amplification and sustained expression of an exogenous gene in vivo
4. Transfer of genetically engineered macrophages into the glomerulus
5. Three-dimensional reconstructed glomerular capillary network: Blood flow distribution and local filtration
6. Transfer of a mutated gene encoding active transforming growth factor-β1 suppresses mitogenesis and IL- 1 response in the glomerulus
7. Gene transfer of interleukin- 1 receptor antagonist into the renal glomerulus via a mesangial cell vector
8. Reduction of proteinuria in anti-glomerular basement membrane nephritis by interleukin-10 gene transfer
9. Creation of a reversible on/off system for site-specific in vivo control of exogenous gene activity in the renal glomerulus
10. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
11. Creation of an in vivo cytosensor using engineered mesangial cells: Automatic sensing of glomerular inflammation controls transgene activity
12. Gene delivery into the renal glomerulus by transfer of genetically engineered, autologous mesangial cells
13. TGF-β1 as an endogenous defender against macrophage-triggered stromelysin gene expression in the glomerulus
14. In vivo transfer of engineered macrophages into the glomerulus: Endogenous TGF-β-mediated defense against macrophage-induced glomerular cell activation
15. The concept of glomerular self-defense
16. Transforming growth factor-β 1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells
17. Identification of an inhibitor targeting macrophage production of monocyte chemoattractant protein-1 as TGF-β 1
18. Mesangial cell-derived transforming growth factor-β 1 reduces macrophage adhesiveness with consequent deactivation
19. NF-κB-mediated self-defense of macrophages faced with bacteria
20. Adoptive transfer of NF-κB-inactive macrophages to the glomerulus