Gene delivery into the renal glomerulus by transfer of genetically engineered, autologous mesangial cells

Experimental Nephrology

Volumn 4, Issue 1, 1996, Pages 56-59

  Kitamura, Masanori ^a,b   Burton, Stephen ^a   Yokoo, Takashi ^a   Fine, Leon G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Galactosidase; Autologous cell transplantation; Gene transfer; Mesangial cell; Renal glomerulus; Transfection

Indexed keywords

BETA GALACTOSIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL TRANSPLANTATION; GENE TRANSFER; GENETIC TRANSFECTION; GLOMERULUS; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BETA-GALACTOSIDASE; CELL TRANSPLANTATION; GENE TRANSFER TECHNIQUES; GENETIC ENGINEERING; GENETIC VECTORS; GLOMERULAR MESANGIUM; KIDNEY GLOMERULUS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030054071     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Kitamura M, Taylor S, Unwin R, Burton S, Shimizu F, Fine LG: Gene transfer into the rat renal glomerulus via a mesangial cell vector: Site-specific delivery, in situ amplification, and sustained expression of an exogenous gene in vivo. J Clin Invest 1994;94: 487-505.
2. Kitamura M, Mitarai T, Maruyama N, Nagasawa R, Yoshida H, Sakai O: Mesangial cell behavior in a three-dimensional extracellular matrix. Kidney Int 1991;40: 653-661.
3. Price J, Turner D, Cepko C: Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci USA 1987;84: 156-160.
4. Kitamura M, Shirasawa T, Maruyama N: Gene transfer of metalloproteinase transin induces aberrant behavior of cultured mesangial cells. Kidney Int 1994;45: 1580-1586.
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7. Palmer TD, Rosman GJ, Osborne WRA, Miller AD: Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced gene. Proc Natl Acad Sci USA 1991;88: 1330-1334.
8. 1, suppresses inflammatory respones in the glomerulus (abstract). J Am Soc Nephrol 1994;5: 695.
9. Maeshima Y, Kashihara N, Sugiyama H, Sekikawa T, Okamoto K, Kanao K, Morita Y, Yamasaki Y, Makino H, Ota Z: Inhibition of mesangial cell proliferation and matrix expansion by antisense oligonucleotides targeting platelet-derived growth factor and transforming growth factor-β (abstract). J Am Soc Nephrol 1994;5:835.