Creation of an in vivo cytosensor using engineered mesangial cells: Automatic sensing of glomerular inflammation controls transgene activity

Journal of Clinical Investigation

Volumn 100, Issue 6, 1997, Pages 1394-1399

  Kitamura, Masanori ^a   Kawachi, Hiroshi ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

CArG box element; Gene therapy; Glomerulonephritis; Mesangial cell; smooth muscle actin

Indexed keywords

ALPHA ACTIN; BETA GALACTOSIDASE; THY 1 ANTIGEN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; GLOMERULONEPHRITIS; MALE; MESANGIUM; NONHUMAN; PRIORITY JOURNAL; RAT; SENSOR; TRANSGENE;

EID: 0030868230     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119659     Document Type: Article

References (51)

1. Kitamura, M., S. Taylor, R. Unwin, S. Burton, F. Shimizu, and L.G. Fine. 1994. Gene transfer into the rat renal glomerulus via a mesangial cell vector. Site-specific delivery, in situ amplification, and sustained expression of an exogenous gene in vivo. J. Clin. Invest. 94:497-505.
2. Kitamura, M., S. Burton, J. English, H. Kawachi, and L.G. Fine. 1995. Transfer of a mutated gene encoding active transforming growth factor-β1 suppresses mitogenesis and IL-1 response in the glomerulus. Kidney Int. 48:1747-1757.
3. Kitamura, M., S. Burton, T. Yokoo, and L.G. Fine. 1996. Gene delivery into the renal glomerulus by transfer of genetically engineered, autologous mesangial cells. Exp. Nephrol. 4:56-59.
4. Kitamura, M. 1997. Gene delivery into the glomerulus via mesangial cell vectors. Exp. Nephrol. 5:118-125.
5. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoter. Proc. Natl. Acad. Sci. USA. 89:5547-5551.
6. Kitamura, M. 1996. Creation of a reversible on/off system for site-specific in vivo control of exogenous gene activity in the renal glomerulus. Proc. Natl. Acad. Sci. USA. 93:7387-7391.
7. Johnson, R.J., J. Floege, A. Yoshimura, H. Iida, W.G. Couser, and C.E. Alpers. 1992. The activated mesangial cell: a glomerular "myofibroblast"? J. Am. Soc. Nephrol. 2:S190-S197.
8. Johnson, R.J., H. Iida, C.E. Alpers, M.W. Majesky, S.M. Schwartz, P. Pritzl, K. Gordon, and A.M. Gown. 1991. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. α-Smooth muscle actin is a marker of mesangial cell proliferation. J. Clin. Invest. 87:847-858.
9. Alpers, C.E., K.L. Hudkins, A.M. Gown, and R.J. Johnson. 1992. Enhanced expression of "muscle-specific" actin in glomerulonephritis. Kidney Int. 41:1134-1142.
10. Elger, M., D. Drenckhahn, R. Nobiling, P. Mundel, and W. Kriz. 1993. Cultured rat mesangial cells contain smooth muscle α-actin not found in vivo. Am. J. Pathol. 142:497-509.
11. MacPherson, B.R., K.O. Leslie, K.V. Lizaso, and J.E. Schwarz. 1993. Contractile cells of the kidney in primary glomerular disorders: an immunohistochemical study using an anti-alpha smooth muscle actin monoclonal antibody. Hum. Pathol. 24:710-716.
12. Kimura, K., J. Hiroi, A. Tojo, N. Suzuki, S. Ohba, N. Mise, M. Omata, and R. Nagai. 1995. Multiplicity of phenotypic modulation in glomerular cells during development of different glomerular diseases. J. Am. Soc. Nephrol. 6: 871. (Abstr.)
13. Floege, J., R.J. Johnson, K. Gordon, H. Iida, P. Pritzl, A. Yoshimura, C. Campbell, C.E. Alpers, and W.G. Couser. 1991. Increased synthesis of extracellular matrix in mesangial proliferative nephritis. Kidney Int. 40:477-488.
14. Floege, J., M.W. Burns, C.E. Alpers, A. Yoshimura, P. Pritzl, K. Gordon, R.A. Seifert, D.F. Bowen-Pope, W.G. Couser, and R.J. Johnson. 1992. Glomerular cell proliferation and PDGF expression precede glomerulosclerosis in the remnant kidney model. Kidney Int. 41:297-309.
15. Johnson, R.J., C.E. Alpers, A. Yoshimura, D. Lombardi, P. Pritzl, J. Floege, and S.M. Schwartz. 1992. Renal injury from angiotensin II-mediated hypertension. Hypertension (Dallas). 19:464-474.
16. Minty, A., and L.J. Kedes. 1986. Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved regulatory motif. Mol. Cell. Biol. 6:2125-2136.
17. Min, B., D.N. Foster, and A.R. Strauch. 1990. The 5′-flanking region of the mouse vascular smooth muscle α-actin gene contains evolutionarily conserved sequence motifs within a functional promoter. J. Biol. Chem. 265:16667-16675.
18. Blank, R.S., T.C. McQuinn, K.C. Yin, M.M. Thompson, K. Takeyasu, R.J. Schwartz, and G.K. Owens. 1992. Elements of the smooth muscle α-actin promoter required in cis for transcriptional activation in smooth muscle. J. Biol. Chem. 267:984-989.
19. Kim, J.-H., P.R. Bushel, and C.C. Kumar. 1993. Smooth muscle α-actin promoter activity is induced by serum stimulation of fibroblast cells. Biochem. Biophys. Res. Commun. 190:1115-1121.
20. Treisman, R. 1986. Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors. Cell. 46:567-574.
21. Simonson, M.S., K. Walsh, C.C. Kumar, P. Bushel, and W.H. Herman. 1995. Two proximal CArG elements regulate SM α-actin promoter, a genetic marker of activated phenotype of mesangial cells. Am. J. Physiol. 268:F760-F769.
22. Treisman, R. 1990. The SRE: a growth factor responsive transcriptional regulator. Semin. Cancer Biol. 1:47-58.
23. Mar, J.H., and C.P. Ordahl. 1988. A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter. Proc. Natl. Acad. Sci. USA. 85:6404-6408.
24. Lee, T.C., Y. Shi, and R.J. Schwartz. 1992. Displacement of BrdU-induced YY1 by serum response factor activates skeletal α-actin transcription in embryonic myoblasts. Proc. Natl. Acad. Sci. USA. 89:9814-9818.
25. Treisman, R. 1992. The serum response element. Trends Biochem. Sci. 17:423-426.
26. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell. 73:381-393.
27. Kitamura, M., T. Mitarai, N. Maruyama, R. Nagasawa, H. Yoshida, and O. Sakai. 1991. Mesangial cell behavior in a three-dimensional extracellular matrix. Kidney Int. 40:653-661.
28. Kitamura, M., T. Shirasawa, and N. Maruyama. 1994. Gene transfer of metalloproteinase transin induces aberrant behavior of cultured mesangial cells. Kidney Int. 45:1580-1586.
29. Meinkoth, J., A. Alberts, and J. Feramisco. 1990. Construction of mammalian cell lines with indicator genes driven by regulated promoters. CIBA Foundation Symp. 150:47-56.
30. Klunder, I., and D.F. Hulser. 1993. Beta-galactosidase activity in transfected Ltk cells is differentially regulated in monolayer and in spheroid cultures. Exp. Cell Res. 207:155-162.
31. Kitamura, M., T. Sütö, T. Yokoo, F. Shimizu, and L.G. Fine. 1996. Transforming growth factor-β1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells. J. Immunol. 156:2964-2971.
32. Kawachi, H., M. Orisaka, K. Matsui, T. Iwanaga, S. Toyabe, T. Oite, and F. Shimizu. 1992. Epitope-specific induction of mesangial lesions with proteinuria by a MoAb against mesangial cell surface antigen. Clin. Exp. Immunol. 88:399-404.
33. Varley, A.W., M.G. Coulthard, R.S. Meidell, R.D. Gerard, and R.S. Munford. 1995. Inflammation-induced recombinant protein expression in vivo using promoters from acute-phase protein genes. Proc. Natl. Acad. Sci. USA. 92:5346-5350.
34. Iida, H., R. Seifert, C.E. Alpers, R.G.K. Grownwald, P.E. Philips, P. Pritzl, K. Gordon, A.M. Gown, R. Ross, D.F. Bowen-Pope, and R.J. Johnson. 1991. Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial cell proliferative nephritis in the rat. Proc. Natl. Acad. Sci. USA. 88:6560-6564.
35. Rupprecht, H.D., V.P. Sukhatme, J. Lacy, R.B. Sterzel, and D.L. Coleman. 1993. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. Am. J. Physiol. 265:F351-F360.
36. Okuda, S., L.R. Languino, E. Ruoslahti, and W.A. Border. 1990. Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J. Clin. Invest. 86:453-462.
37. Imai, E., M. Arai, Y. Isaka, A. Wada, T. Sugiura, Y. Akagi, M. Miyazaki, Y. Fjiwara, N. Ueda, and T. Kamada. 1994. Phenotypic change of the mesangial cells is induced by overexpression of the TGF-β in in vivo glomerulus. J. Am. Soc. Nephrol. 5:782. (Abstr.)
38. Rupprecht, H.D., V.P. Sukhatme, A.P. Rupprecht, R.B. Sterzel, and D.L. Coleman. 1994. Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene-1 by arginine vasopressin in rat mesangial cells. J. Cell. Physiol. 159:311-323.
39. Simonson, M.S., Y. Wang, and W.H. Herman. 1996. Nuclear signaling by endothelin-1 requires Src protein-tyrosine kinases. J. Biol. Chem. 271:77-82.
40. Johnson, R.J., J. Floege, W.G. Couser, and C.E. Alpers. 1993. Role of platelet-derived growth factor in glomerular disease. J. Am. Soc. Nephrol. 4: 119-128.
41. Border, W.A., and E. Ruoslahti. 1992. Transforming growth factor-β in disease. The dark side of tissue repair. J. Clin. Invest. 90:1-7.
42. Rosenberg, M.E., L.J. Smith, R. Correa-Rotter, and T.H. Hostetter. 1994. The paradox of the renin-angiotensin system in chronic renal disease. Kidney Int. 45:403-410.
43. Marsen, T.A., H. Schramek, and M.J. Dunn. 1994. Renal actions of endothelin: linking cellular signaling pathways to kidney disease. Kidney Int. 45: 336-344.
44. 6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation. Proc. Natl. Acad. Sci. USA. 90:2419-2422.
45. Sadoshima, J., and S. Izumo. 1993. Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO (Eur. Mol. Biol. Organ.) J. 12:1681-1692.
46. Aoyagi, T., and S. Izumo. 1993. Mapping of the pressure response element of the c-fos gene by direct DNA injection into beating hearts. J. Biol. Chem. 268:27176-27179.
47. Carson, J.A., Z. Yan, F.W. Booth, M.E. Coleman, R.J. Schwartz, and C.S. Stump. 1995. Regulation of skeletal α-actin promoter in young chickens during hypertrophy caused by stretch overload. Am. J. Physiol. 268:C918-C924.
48. Narita, I., Y. Nakagawa, K. Igarashi, H. Kimura, T. Takeda, T. Kutsuwada, H. Yamazaki, F. Shimuzu, and M. Arakawa. 1995. In vivo activation of transcription factors AP-1 and NF-κB in isolated glomeruli from rat with experimental glomerulonephritis. J. Am. Soc. Nephrol. 6:805. (Abstr.)
49. Sekikawa, T., N. Kashihara, K. Okamoto, Y. Maeshima, K. Kanao, H. Sugiyama, H. Makino, and Z. Ota. 1995. Detection of activated transcription factors in glomerulonephritis. J. Am. Soc. Nephrol. 6:883. (Abstr.)
50. Angel, P., and M. Karin. 1991. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta. 1072:129-157.
51. Baeuerle, P.A., and T. Henkel. 1994. Function and activation of NF-kappa B in the immune system. Annu. Rev. Immunol. 12:141-179.