Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: Enhanced detection by β-amyloid precursor protein immunohistochemical staining

Archives of Pathology and Laboratory Medicine

Volumn 123, Issue 2, 1999, Pages 146-151

  Gleckman, Aaron M ^a   Bell, Michael D ^b   Evans, Richard J ^c   Smith, Thomas W ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Miami Dade Medical Examiner Department   (United States)

^c Off Chf Med Examiner M   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PROTEIN PRECURSOR;

BLUNT TRAUMA; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; CELL SWELLING; CONFERENCE PAPER; FORENSIC PATHOLOGY; HEAD INJURY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NERVE INJURY; SILVER IMPREGNATION; WATER CONTENT;

ADULT; AMYLOID BETA-PROTEIN PRECURSOR; AXONS; BATTERED CHILD SYNDROME; BRAIN; BRAIN INJURIES; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MALE;

EID: 0032941035     PISSN: 00039985     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (24)

1. Graham DI, Gennarelli TA. Trauma. In: Graham DI, Lantos PL, eds. Greenfield's Neuropathology. 6th ed. London, England: Arnold; 1997:197-262.
2. Caffrey J. On the theory and practice of shaking infants: its potential residual effects of permanent brain damage and mental retardation. Am J Dis Child. 1972; 124:161-169.
3. Merten DF, Osborne DRS. Craniocerebral trauma in the child abuse syndrome. Pediatr Ann. 1983;12:882-887.
4. Leestma JE. Forensic neuropathology. In: Duckett S, ed. Pediatric Neuropathology. Baltimore, Md: Williams & Wilkins; 1995:243-283.
5. Caffrey J. The whiplash shaken infant syndrome: manual shaking by the extremities with whiplash-induced intracranial and intraocular bleeding, linked with residual permanent brain damage and mental retardation. Pediatrics. 1974; 54:396-403.
6. Gultekin SH, Smith TW. Diffuse axonal injury in craniocerebral trauma: a comparative histologic and immunohistochemical study. Arch Pathol Lab Med. 1994;118:168-171.
7. Grady MS, McLaughlin MR, Christman CW, Valadka AB, Fligner CL, Povlishock JT. The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J Neuropathol Exp Neurol. 1993; 52:143-152.
8. Sherriff FE, Bridges LR, Gentleman S, Sivaloganathan S, Wilson S. Markers of axonal injury in postmortem human brain. Acta Neuropathol. 1994;88:433-439.
9. Gentleman SM, Nash MJ, Sweetin CJ, Graham DI, Roberts GW. β-Amyloid precursor protein (β-APP) as a marker of axonal injury after head injury. Neurosci Lett. 1993;160:139-144.
10. Sherriff FE, Bridges LR, Sivaloganathan S. Early detection of axonal injury after human head trauma using immunocytochemistry for β-amyloid precursor protein. Acta Neuropathol. 1993;87:57-62.
11. Gentleman SM, Roberts GW, Gennarelli TA, et al. Axonal injury: a universal consequence of fatal closed head injury? Acta Neuropathol. 1995;89:537-543.
12. McKenzie KJ, McLellan DR, Gentleman SM, Maxwell WL, Gennarelli TA, Graham DI. Is β-APP a marker of axonal damage in short-surviving head injury? Acta Neuropathol. 1996;92:608-613.
13. Geddes JF, Vowles GH, Beer TW, Ellison DW. The diagnosis of diffuse axonal injury: implications for forensic practice. Neuropathol Appl Neurobiol. 1997;23:339-347.
14. Koo EH, Sisodia SS, Archer DR, et al. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci USA. 1990;87:1561-1565.
15. Maxwell WL, Povlishock JT, Graham DL. A mechanistic analysis of non-disruptive axonal injury: a review. J Neurotrauma. 1997;15:419-440.
16. Vowles GH, Scholtz CL, Cameron JM. Diffuse axonal injury in early infancy. J Clin Pathol. 1987;40:185-189.
17. Naoumenko J, Feigin I. A stable silver solution for axon staining in paraffin sections. J Neuropathol Exp Neurol. 1967;26:669-673.
18. DiMaio DJ, DiMaio VJM. Forensic Pathology. Boca Raton, Fla: CRC Press Inc; 1993.
19. Blumbergs PC, Jones NR, North JB. Diffuse axonal injury and head trauma. J Neurol Neurosurg Psychiatry. 1989;52:838-841.
20. Ferreira A, Caceras A, Kosik KS. Intraneuronal compartments of the amyloid precursor protein. J Neurosci. 1993;13:3112-3123.
21. Kreutzberg GW, Blakemore WF, Graeber MB. Cellular pathology of the central nervous system. In: Graham DI, Lantos PL, eds. Greenfield's Neuropathology. 6th ed. London, England: Arnold; 1997:85-156.
22. Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, McLean AJ. Staining of amyloid precursor protein to study axonal damage in mild head injury. Lancet. 1994;334:1055-1056.
23. Yam PS, Takasago T, Dewar D, Graham DI, Mcculloch J. Amyloid precursor protein accumulates in white matter at the margin of a focal ischaemic lesion. Brain Res. 1997;760:150-157.
24. Shannon P, Smith CR, Deck J, Ang LC, Ho M, Becker L. Axonal injury and the neuropathology of shaken baby syndrome. Acta Neuropathol. 1998;95:625-631.