Mutant frequency and molecular analysis of in vivo lacI mutations in the bone marrow of big blue® rats treated with 7,12-dimethylbenz[a]anthracene

Environmental and Molecular Mutagenesis

Volumn 36, Issue 3, 2000, Pages 235-242

  Shelton, Sharon D ^a   Cherry, Veronica ^b   Manjanatha, Mugimane G ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b LOUISIANA TECH UNIVERSITY   (United States)

Author keywords

Carcinogenesis; DBMA; Genotoxicity; Mutagenesis; Mutant frequency; Transgenic model

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BREAST; CARCINOGENESIS; CELL PROLIFERATION; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DNA ADDUCT; DNA SEQUENCE; FEMALE; GENE FREQUENCY; GENE MUTATION; GENOTOXICITY; LYMPHOCYTE; MUTANT; NONHUMAN; POINT MUTATION; RAT; SEQUENCE ANALYSIS; TRANSGENIC MOUSE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; BACTERIAL PROTEINS; BONE MARROW CELLS; CARCINOGENS; DNA; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FEMALE; GENE TRANSFER TECHNIQUES; LYMPHOCYTES; MAMMARY GLANDS, ANIMAL; MUTAGENESIS; MUTAGENICITY TESTS; MUTAGENS; RATS; RATS, INBRED STRAINS; REPRESSOR PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 0033754118     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2280(2000)36:3<235::AID-EM7>3.0.CO;2-D     Document Type: Article

References (31)

1. How the lac repressor binds to DNA
2. Evidence for two DNA repair enzymes for 8-hydroxyguanine in human cells
3. Mutational analysis of the liver, colon and kidney of BB rats treated with 2-amino-3-methylimidazo[4,5-f]quinoline
4. Spontaneous tumors in the rat
5. Computer program for the analysis of mutational spectra: Application to p53 mutations
6. Comparative dose-response tumorigenicity studies of dibenzo[a,1]pyrene versus DMBA, BP and two dibenzo[a,L]pyrene dihydrodiols in mouse skin and rat mammary gland
7. Transgenic mouse mutation assay system can play an important role in regulatory mutagenicity testing in vivo for the detection of site-of-contact mutagens
8. Spontaneous mutation in lacI transgenic mice: A comparison of tissues
9. The use of shuttle vectors for mutation analysis in transgenic mice and rats
10. Species-specific differences in hepatic mutant frequency and mutational spectrum among lambda/lacI transgenic rats and mice following exposure to aflatoxin B1
11. Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacements of 5-methylcytosine residues with cytosine residues
12. Sequence of the lacI gene
13. Mutational spectra in the lacI gene in skin from DMBA-treated and untreated transgenic mice
14. Induction of lacZ mutation by DMBA in various tissues of transgenic mice
15. Bone marrow stromal cells constitutively express high levels of Cytochrome P4501B1 that metabolize DMBA
16. Carcinogenic responses to chemical applied directly to rat mammary glands in situ
17. Mammary cancer induced by a single feeding of polynuclear hydrocarbons, and its suppression
18. Effects of progesterone on mammary carcinogenesis when various doses of DMBA were applied directly to rat mammae
19. Mutagenicity of the potent rat hepatocarcinogen 6BT to the liver of transgenic(lacI) rats: Consideration of a reduced mutation assay protocol
20. Molecular analysis of lacI mutations in Rat2(TM) cells exposed to DMBA: Evidence for DNA sequence and DNA strand biases for mutation
21. Lymphocyte mutant frequency in relation to DNA adduct formation in rats treated with tumorigenic doses of the mammary gland carcinogen DMBA
22. Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue rats treated with DMBA
23. DNA adduct formation and molecular analysis of in vivo lacI mutations in the mammary tissue of BB rats treated with DMBA
24. A comparison of the types of mutations induced by DMBA in the lacI and Hprt genes of Big Blue rats
25. Comparison of DMBA metabolism and DNA binding in mammary epithelial cells from three rat strains with different susceptibilities to mammary carcinogenesis
26. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis
27. A direct mechanism of mammary carcinogenesis induced by DMBA
28. The relationship between mutant frequency and time in vivo: Simple predictions for any tissue, cell type, or mutagen
29. Adjusted p-values for simultaneous inference
30. Tumors of the mammary gland
31. Tumors of the skin