Molecular mechanisms of glucocorticoid resistance/hypersensitivity: Potential clinical implications

American Journal of Respiratory and Critical Care Medicine

Volumn 154, Issue 2 SUPPL., 1996, Pages

  Chrousos, George P ^a   Castro, Margaret ^b   Leung, Donald Y M ^b   Webster, Elizabeth ^b   Kino, Tomoshige ^b   Bamberger, Christoph ^b   Elliot, Sharon ^b   Stratakis, Constantine ^b   Karl, Michael ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; DEOXYCORTICOSTERONE; HYDROCORTISONE; PRASTERONE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALTERNATIVE RNA SPLICING; DRUG HYPERSENSITIVITY; FEEDBACK SYSTEM; HUMAN; MOLECULAR DYNAMICS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STEROID THERAPY; TISSUE SPECIFICITY;

EID: 0029737871     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm/154.2_pt_2.s39     Document Type: Review

References (28)

1. Mechanisms of physical and emotional stress. In G. P. Chrousos, D. L. Loriaux, and P. W. Gold, editors. 1988. Advances in Experimental Medicine and Biology, Vol. 245. Plenum Press, New York.
2. Steroid hormone resistance: mechanisms and clinical aspects. In G. P. Chrousos, D. L. Loriaux, and M. B. Lipsett, editors. 1986. Advances in Experimental Medicine and Biology, Vol. 196. Plenum Press, New York.
3. Chrousos, G. P., S. Detera-Wadleigh, and M. Karl. 1993. Syndromes of glucocorticoid resistance. Ann. Intern. Med. 119:1113-1124.
4. Keightley, M. C., and P. J. Fuller. 1995. Cortisol resistance and the guinea pig glucocorticoid receptor. Steroids 60:87-92.
5. DeVries, C. A., M. B. DeVries, S. Taymans, and C. S. Carter. 1995. Modulation of pair bonding in female prairie voles (Microtus Ochrogaster) by corticosterone. Proc. Natl. Acad. Sci. U.S.A. 92:7744-7748.
6. DeKloet, E. R. 1991. Brain corticosteroid receptor balance and homeostatic control. Front. Neuroendocrinol. 12:95-164.
7. Evans, R. M. 1988. The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
8. Boumpas, D. T., G. P. Chrousos, R. L. Wilder, T. R. Cupps, and J. E. Balow. 1993. Glucocorticoid therapy in immune-related diseases: basic and clinical correlates. Ann. Intern. Med. 119:1198-1208.
9. Ray, A., and K. E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U.S.A. 91:752-756.
10. Caldenhoven, E., J. Liden, S. Wissnik, A. Van de Stolpe, J. Raaijmakers, L. Koenderman, S. Okret, J. A. Gustafsson, and P. T. Vander Saag. 1995. Negative cross talk between Rel A and glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids. Mol. Endocrinol. 9:401-412.
11. Scheinman, R. L., A. Gualberto, C. M. Jewell, J. A. Aldowski, and A. S. Baldwin, Jr. 1995. Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Mol. Cell. Biol. 15:943-953.
12. Encio, I. J., and S. D. Detera-Wadleigh. 1991. The genomic structure of the human glucocorticoid receptor. J. Biol. Chem. 266:7182-7188.
13. Nobukumi, Y., C. L. Smith, G. L. Hager, and S. D. Detera-Wadleigh. 1995. Characterization of the human glucocorticoid receptor promoter. Biochemistry 34:8207-8214.
14. Bamberger, C. M., A. M. Bamberger, M. De Castro, and G. P. Chrousos. 1995. Glucocorticoid receptor-beta, a potential endogenous inhibitor of glucocorticoid action in humans. J. Clin. Invest. 95:2435-2441.
15. Vamvakopoulos, N. C., K. Fukuhara, V. K. Patchev, and G. P. Chrousos. 1993. Effect of single and repeated immobilization stress on the heat shock protein (HSP) 70/90 system in the rat: glucocorticoid-independent, reversible reduction of HSP90 in the liver and spleen. Neuroendocrinology 57:1057-1065.
16. Patchev, V. K., L. S. Brady, M. Karl, and G. P. Chrousos. 1994. Gene expression of HSP90 and glucocorticoid receptors in the brain: evidence for coordinate regulation by adrenal steroid levels in vivo. Cell Mol. Endocrinol. 103:57-64.
17. Corrigan, C. J., P. H. Brown, N. C. Barnes, J. J. Tsai, A. J. Frew, and A. B. Kay. 1991. Glucocorticoid resistance in chronic asthma: peripheral blood T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A. Am. Rev. Respir. Dis. 144:1026-1032.
18. Sher, E. R., D. V. M. Leung, W. Surs, J. C. Kam, G. Zieg, A. K. Kamada, and S. J. Szefler. 1994. Steroid-resistant asthma: cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J. Clin. Invest. 93:33-39.
19. Adcock, I. M., S. J. Lane, C. R. Brown, M. J. Peters, T. H. Lee, and P. J. Barnes. 1995. Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma. J. Immunol. 154:3500-3505.
20. Watt, G. C. M., S. B. Harrap, C. J. W. Foy, D. W. Holton, H. V. Edwards, H. R. Davidson, J. M. Connor, A. F. Lever, and R. Fraser. 1992. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: a four corners approach to the identification of genetic determinants of blood pressure. J. Hypertension 10:473-482.
21. Weaver, J. V., G. A. Hitman, and P. G. Kopelman. 1992. An association between a BcP1 restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women. J. Mol. Endocrinol. 9:295-300.
22. Hurley, D., D. Accilli, C. Stratakis, M. Karl, N. Vamvakopoulos, E. Rorer, K. Constantine, S. Taylor, and G. P. Chrousos. 1991. Mutation of the glucocorticoid receptor gene in familial glucocorticoid resistance. J. Clin. Invest. 87:680-686.
23. Karl, M., S. W. Lamberts, S. Detera-Wadleigh, J. J. Encio, C. A. Stratakis, D. M. Hurley, D. Accili, and G. P. Chrousos. 1993. Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene. J. Clin. Endocrinol. Metab. 76:683-689.
24. Nathan, D. F., and S. Lindquist. 1995. Mutational analysis of HSP 90 function: interactions with a steroid receptor and a protein kinase. Mol. Cell. Biol. 15:3917-3925.
25. Kang, K. I., J. Devin, F. Cadepond, N. Jibard, A. Guiochon-Mantel, E. F. Baulieu, and M. G. Catelli. 1994. In vivo functional protein-protein interaction: nuclear targeted HSP 90 shifts cytoplasinic steroid receptors into the nucleus. Proc. Natl. Acad. Sci. U.S.A. 91: 340-344.
26. Karl, M., G. Von Wichert, E. Kempter, D. A. Katz, M. Reincke, H. Monig, I. U. Ali, C. A. Stratakis, E. H. Oldfield, G. P. Chrousos, and H. M. Schulte. 1996. Nelson's syndrome associated with a somatic frame shift mutation in the glucocorticoid receptor gene. J. Clin. Endocrinol. Metab. 81:124-129.
27. Refaeli, Y., D. N. Levy, and D. B. Weiner. 1995. The glucocorticoid receptor type 11 complex is a target of the HIV-1 vpr gene product. Proc. Natl. Acad. Sci. U.S.A. 92:3621-3625.
28. Norbiato, G., M. Bevilaqua, T. Vago, G. Baldi, E. Chebat, P. Bertora, M. Moroni, M. Galli, and N. Oldenburg. 1992. Cortisol resistance in acquired immunodeficiency syndrome. J. Clin. Endocrinol. Metab. 74:608-613.