Neurobiology of addictive behaviors and its relationship to methadone maintenance

Mount Sinai Journal of Medicine

Volumn 67, Issue 5-6, 2000, Pages 375-380

  Stimmel, Barry ^a   Kreek, Mary Jeanne ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Heroin; Heroin addiction; Methadone; Methadone maintenance; Neurobiology of addiction

Indexed keywords

DIAMORPHINE; METHADONE; OPIATE; OPIATE AGONIST;

BEHAVIOR THERAPY; CLINICAL RESEARCH; CONFERENCE PAPER; DRUG TOLERANCE; DRUG WITHDRAWAL; ENVIRONMENTAL FACTOR; GENETIC SUSCEPTIBILITY; HEROIN DEPENDENCE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; METHADONE TREATMENT; NEUROBIOLOGY; OPIATE ADDICTION; STRESS;

ANALGESICS, OPIOID; BEHAVIOR, ADDICTIVE; BRAIN; HEROIN DEPENDENCE; HUMANS; METHADONE; MODELS, NEUROLOGICAL;

EID: 0033753550     PISSN: 00272507     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (20)

1. Gardner E. Neurobiological substrates for substance abuse. Cocaine/Crack Research Working Group Newsletter 1991; 1:6-7. (Can be obtained from Herman Joseph, Ph.D., OASAS, New York, NY)
2. Hyman SE. Molecular and cell biology of addiction. Curr Opin Neurol Neurosurg 1993; 6:609-613.
3. Nutt DJ. Addictive brain mechanisms and their treatment implications. Lancet 1996; 347:31-36.
4. Kreek MJ, Koob GF. Drug dependence: Stress and dysregulation of brain reward pathways. Drug Alcohol Depend 1998; 51:23-47.
5. Uhl GR, Kreek MJ, Gorelick DA. Rates of dopamine transport and mu opiate receptor occupancies, cocaine and heroin reward and therapeutic opportunities. Grand Rounds. Bethesda, MD: National Institutes of Health Clinical Center: 1995. NIDA Notes March/April 1997. pp. 8-11.
6. Koob GF, Le Moal M. Drug abuse: Hedonic homeostatic regulation. Science 1997; 278:52-57.
7. Volkow ND, Wang GJ, Fischman NW, et al. Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 1997; 386:827-830.
8. Rocha BA, Fumagalli F, Gainetdinov RR, et al. Cocaine self-administration in dopamine-transporter knockout mice. Nat Neurosci 1998; 1(2):132-137. [Published erratum appears in Nat Neuurosci 1998; 1(4):330.]
9. 1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: Gender differences and implications for modulations of dopaminergic tone in the treatment of addictions. J Pharmacol Exp Ther 1999; 288:260-269.
10. Greenwald MK, Stitzer ML, Haberny KA. Human pharmacology of the opioid neuropeptide dynorphin A1-13. J Pharmacol Exp Ther 1996; 281:974-977.
11. King AC, Ho A, Schluger J, et al. Acute subjective effects of dynorphin A(1-13) infusion in normal healthy subjects. Drug Alcohol Depend 1999; 54:87-90.
12. Nestler EJ, Aghajanian GK. Molecular and cellular basis of addiction. Science 1997; 278:58-65.
13. Stimmel B, Kreek MJ. Pharmacologic actions of heroin. In: Stimmel B, editor. Heroin dependency: Medical, economic and social aspects. New York: Stratton Intercontinental Medical Book Corp.; 1975. pp. 71-87.
14. Dole VP, Nyswander ME, Kreek MJ. Narcotic blockade. Arch Intern Med 1966; 188:304-309.
15. Kreek MJ. Rationale for maintenance pharmacotherapy of opiate dependence. In: O'Brien CP, Jaffe JH, editors. Addictive states. New York: Raven Press; 1992. pp. 205-230.
16. Kreek MJ. Clinical update of opioid agonist and partial agonist medications for the maintenance treatment of opioid addiction. Semin Neurosci 1997; 9:140-157.
17. Stimmel B, Glick SD. Animal-human correlates of narcotic dependence: A brief review. Am J Psychiatry 1978; 135:821-825.
18. Kreek MJ, Opiates, opioids, SNP's and the addictions: Nathan B. Eddy Memorial Award for lifetime excellence in drug abuse research lecture. In: Harris LS, editor. Problems of drug dependence; 1999. Proceedings of the 61st Annual Scientific Meeting of the College on Problems of Drug Dependence. National Institute of Drug Abuse Research Monograph Series. In press.
19. American Methadone Treatment Association. Methadone Maintenance Provider Survey. 1998. [217 Broadway, New York, NY 10001, (212) 566-5555]
20. Effective medical treatment of opiate addiction. National conference development panel on effective medical treatment of opiate addiction. JAMA 1998; 280:1936-1943.