The human endogenous retrovirus K Rev response element coincides with a predicted RNA folding region

RNA

Volumn 6, Issue 11, 2000, Pages 1551-1564

  Yang, Jin ^a   Bogerd, Hal ^a   Le, Shu Yun ^b   Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Nuclear export; Retrovirus; Rev; RNA binding; RNA structure

Indexed keywords

CIS ACTING ELEMENT; NUCLEAR RNA; REV PROTEIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE MUTATION; HUMAN; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROVIRUS; RNA BINDING; RNA SEQUENCE; RNA STRUCTURE; SEQUENCE ANALYSIS; TARGET CELL;

BASE SEQUENCE; CELL LINE; ENDOGENOUS RETROVIRUSES; GENOME, HUMAN; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEIC ACID CONFORMATION; RECOMBINANT PROTEINS; RNA, VIRAL; SACCHAROMYCES CEREVISIAE; SEQUENCE DELETION; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

ANIMALIA; DNA VIRUSES; HUMAN ENDOGENOUS RETROVIRUS; HUMAN ENDOGENOUS RETROVIRUS K; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; UNIDENTIFIED RETROVIRUS;

EID: 0033749806     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S135583820000100X     Document Type: Article

References (48)

1. Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans
2. HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA
3. Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus
4. Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism
5. Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases
6. Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1
7. Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element
8. Functional differences between human and bovine immunodeficiency virus Tat transcription factors
9. A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent
10. A computational procedure for assessing the significance of RNA secondary structure
11. Nuclear RNA export pathways
12. CRM1 is an export receptor for leucine-rich nuclear export signals
13. Improved free-energy parameters for prediction of RNA duplex stability
14. Identification of the activation domain of equine infectious anemia virus Rev
15. A novel exogenous retrovirus sequence identified in humans
16. A single stem-loop structure within the HTLV-I Rex response element is sufficient to mediate Rex activity in vivo
17. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus
18. Involvement of human CRM1 (Exportin 1) in the export and multimerization of the Rex protein of human T-cell leukemia virus type I
19. Comparative analysis of the HTLV-I rex and HIV-1 rev trans-regulatory proteins and their RNA response elements
20. Human immunodeficiency virus type 1 regulator of virion expression, rev, forms nucleoprotein filaments after binding to a purine-rich 'bubble' located within the rev-responsive region of viral mRNAs
21. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: Mapping cryptic functions of the arginine-rich motif
22. Minimal Rev-response element for type 1 human immunodeficiency virus
23. Recognition of the high affinity binding site in Rev-response element RNA by the human immunodeficiency virus type-1 Rev protein
24. Improved predictions of secondary structures for RNA
25. The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
26. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
27. Prediction of alternative RNA secondary structures based on fluctuating thermodynamic parameters
28. A method for assessing the statistical significance of RNA folding
29. A highly conserved RNA folding region coincident with the Rev response element of primate immunodeficiency viruses
30. cORF and RcRE, the Rev/Rex and RRE/RxRE homologues of the human endogenous retrovirus family HTDV/HERV-K
31. HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: Implications for HIV-1 latency
32. The HIV-1 Rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
33. HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence
34. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure
35. Human-specific integrations of the HERV-K endogenous retrovirus family
36. The importinbeta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
37. Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome
38. Our retroviral heritage
39. The HIV-1 Rev protein
40. A three-hybrid system to detect RNA-protein interactions in vivo
41. Exportin 1 (Crm1p) is an essential nuclear export factor
42. Tat transactivation: A model for the regulation of eukaryotic transcriptional elongation
43. Structural and functional analysis of the visna virus Rev-response element
44. The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence
45. Identification and characterization of novel human endogenous retrovirus families by phylogenetic screening of the human genome mapping project database
46. An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein
47. Sequence-specific RNA binding by the HIV-1 Rev protein
48. Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: A dual function for an arginine-rich binding motif