Alpha2-adrenoceptor agonists: Analgesia, sedation, anxiolysis, haemodynamics, respiratory function and weaning

Bailliere's Best Practice and Research in Clinical Anaesthesiology

Volumn 14, Issue 2, 2000, Pages 433-448

  Mantz, Jean ^a  

^a BICHAT HOSPITAL   (France)

Author keywords

Analgesia; Critically ill; Dexmedetomidine; Respiratory depression; Rousability; Sedation; Sympatholysis

Indexed keywords

ALFENTANIL; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; DEXMEDETOMIDINE; FENTANYL; IDAZOXAN; ISOFLURANE; MIDAZOLAM; MORPHINE; OPIATE; PROPOFOL;

ANALGESIA; ARTIFICIAL VENTILATION; CLINICAL TRIAL; CRITICAL ILLNESS; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; EXPERIMENTAL MODEL; HEALTH CARE COST; HEMODYNAMICS; HUMAN; INTENSIVE CARE UNIT; NONHUMAN; PAIN; PRIORITY JOURNAL; RESPIRATION DEPRESSION; REVIEW; SEDATION; TRANQUILIZING ACTIVITY; WEANING;

EID: 0033749717     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1053/bean.2000.0094     Document Type: Article

References (82)

1. Sedation in the intensive care unit: A systematic review
2. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation
3. Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: An executive summary. Society of Critical Care Medicine
4. Inhibition of adenylate cyclase in the locus ceruleus mediates the hypnotic response to an α2 agonist in the rat
5. Dexmedetomidine, a novel α2-adrenergic agonist. A review of its pharmacodynamic characteristics
6. Central α2-adrenoceptors are highly selective for dexmedetomidine, the dextroenantiomer of medetomidine
7. Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine
8. Perioperative sympatholysis. Beneficial effects of the α2-adrenoceptor agonist mivazerol in hemodynamic stability and myocardial ischemia
9. Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha2adrenoceptor antagonist atipamezole: A pharmacodynamic and kinetic study in healthy volunteers
10. Psychological and psychiatric aspects of pain
11. Sedation in the intensive care unit
12. Pain assessment. The problem of pain in the critically ill patient
13. Effect of analgesic treatment on the physiological consequences of acute pain
14. Assessment of sedation, analgesia, and neuromuscular blockade in the perioperative period
15. Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep
16. Spinal and systemic action of the α2 receptor agonist dexmedetomidine in dogs. Antinociception and carbon dioxide responses
17. Antinociceptive properties of intrathecal dexmedetomidine in rats
18. The effect of medetomidine, an α2 adrenoceptor agonist, in various pain tests
19. Spinal antinociception by dexmedetomidine, a highly selective α2-adrenergic agonist
20. Potentiation of the analgesic properties of fentanyl-like opioids with the α2-adrenoceptor agonists in rats
21. α2-adrenoceptor agonists: Defining their role in clinical anesthesia
22. The analgesic action of dexmedetomidine - A novel α2-adrenoceptor agonist - In healthy volunteers
23. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions
24. Effects of a single preoperative dexmedetomidine dose on requirements and perioperative haemodynamic stability
25. Intramuscular dexmedetomidine as premedication for general anesthesia: A comparative multicenter study
26. Effect of intravenously administered dexmedetomidine on pain after laparoscopic tubal ligation
27. Dexmedetomidine efficacy for ICU postoperative sedation
28. Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine
29. Effects of premedication on dose requirements for propofol: Comparison of clonidine and hydroxizine
30. A comparison of dexmedetomidine, an α2-adrenoceptor agonist and midazolam as i.m. premedication for minor gynaecological surgery
31. Controlled sedation with alphaxolone-alphadolone
32. The effects of selective α2-adrenergic agents on performance of rats in a 5-choice serial reaction time task
33. Dexmedetomidine reduces response tendency, but not accuracy of rats in attention and short-term memory tasks
34. Sensitivity and accuracy of the visual analogue scale: A psycho-social classroom experiment
35. Assessment of the sedative effects of dexmedetomidine, an α2-adrenoceptor agonist, with analysis of saccadic eye movements
36. Measurement of recovery from outpatient general anesthesia with a simple ocular test
37. Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects - A review
38. Saccadic eye movement analysis as a measure of drug effects on human psychomotor performance
39. Long term postoperative cognitive dysfunction in the elderly. ISPOCD I study
40. Psychiatric syndromes in critically ill patients
41. Psychological reactions to acute medical illness and critical care
42. Sedation in the ICU
43. Overnight sedation with midazolam or propofol in the ICU: Effects on sleep quality, anxiety and depression
44. The correlation between sleep deprivation and the intensive care unit syndrome
45. Dexmedetomidine premedication before intravenous regional anaesthesia in minor outpatient hand surgery
46. The Hospital Anxiety and Depression Scale
47. Intramuscularly administered dexmedetomidine attenuates hemodynamic and stress hormone responses to gynecologic laparoscopy
48. Should we all have a sympathectomy at birth? Or at least preoperatively?
49. Myocardial ischaemia in untreated hypertensive patients: Effect of a single small oral dose of a β-adrenergic blocking agent
50. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery
51. Beta-blockers after myocardial infarction. For few patients, or many?
52. The effect of heart rate control on myocardial ischemia among high-risk patients after vascular surgery
53. Perioperative cardiac morbidity: Epidemiology, costs, problems and solutions
54. Effect of clonidine on the circulation and vasoactive hormones after aortic surgery
55. Clinical perspective of α2-adrenoceptor agonists
56. Effect of mivazerol on perioperative cardiac complications during non-cardiac surgery in patients with coronary heart disease. The European Mivazerol Trial
57. Haemodynamic effects of dexmedetomidine, an α2-adrenergic agonist, in autonomically denervated dogs
58. Effects of dexmedetomidine, an α2-adrenergic agonist, on the isolated heart
59. The effect of dexmedetomidine on systemic haemodynamics, regional myocardial function and blood flow during coronary artery stenosis in acute anaesthetized dogs
60. Effects of dexmedetomidine on coronary haemodynamics and myocardial oxygen balance
61. Effects of intravenous dexmedetomidine in humans
62. Comparison of intramuscular dexmedetomidine and midazolam premedication for elective abdominal hysterectomy
63. Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting
64. Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes
65. Preliminary experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit
66. Is gaining control of the autonomic nervous system important to our specialty?
67. Ventilator-induced lung injury: Lessons from experimental studies
68. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome
69. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome
70. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
71. The acute respiratory distress syndrome
72. The relationship of pneumothorax and other air leaks to mortality in the acute respiratory distress syndrome
73. Reducing the use of mechanical ventilation
74. A comparison of four methods of weaning patients from mechanical ventilation
75. Comparison of three methods of gradual withdrawal from ventilatory support weaning from mechanical ventilation
76. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously
77. Inspiratory pressure support compensates for the additional work of breathing caused by the endotracheal tube
78. Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease
79. Dexmedetomidine, a selective α2 agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat
80. Ventilatory effects of dexmedetomidine, atipamezole and isoflurane in dogs
81. Ventilatory, hemodynamic and sedative effects of the α2 adrenergic agonist dexmedetomidine
82. Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation and metabolic rate