Deletion of the propeptide of apolipoprotein A-I reduces protein expression but stimulates effective conversion of preβ-high density lipoprotein to α-high density lipoprotein

Journal of Lipid Research

Volumn 41, Issue 11, 2000, Pages 1872-1882

  Sviridov, D ^a   Pyle, L E ^a   Jauhiainen, M ^a   Ehnholm, C ^a   Fidge, N H ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Atherosclerosis; Cholesterol efflux; Reverse cholesterol transport

Indexed keywords

CHOLESTEROL ACYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN; PHOSPHATIDYLCHOLINE; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; VIRUS VECTOR;

ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIPOPROTEIN SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; SKIN FIBROBLAST;

ANIMALS; APOLIPOPROTEIN A-I; BACULOVIRIDAE; CHOLESTEROL; CIRCULAR DICHROISM; FIBROBLASTS; HUMANS; INSECTS; LIPOPROTEINS, HDL; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; PHOSPHOLIPIDS; PROTEIN PRECURSORS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0033747037     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Molecular physiology of the reverse cholesterol transport
2. Molecular mechanisms of reverse cholesterol transport
3. High density lipoprotein and lipoprotein oxidation
4. HDL(3)-mediated inhibition of thrombin-induced platelet aggregation and fibrinogen binding occurs via decreased production of phosphoinositide-derived second messengers 1,2-diacylglycerol and inositol 1,4,5-tris-phosphate
5. Lipoprotein trafficking in vascular cells. Molecular Trojan horses and cellular saboteurs
6. Regulation of leucocyte-endothelial interactions of special relevance to atherogenesis
7. High-density lipoproteins inhibit cytokine-induced expression of endothelial cell adhesion molecules
8. Phosphoproteins regulated by the interaction of high-density lipoprotein with human skin fibroblasts
9. Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol
10. Secretion and processing of apolipoprotein A-I in the avian sciatic nerve during development
11. Secretion of apoB- and apoA-I-containing lipoproteins by chick kidney
12. Nucleotide sequence and the encoded amino acids of human apolipoprotein A-I mRNA
13. In vitro conversion of proapoprotein A-I to apoprotein A-I. Partial characterization of an extracellular enzyme activity
14. Familial HDL deficiency characterized by hypercatabolism of mature apoA-I but not proapoA-I
15. Production of mature human apolipoprotein A-I in a baculovirus-insect cell system: Propeptide is not essential for intracellular processing but may assist rapid secretion
16. Deletion of the propeptide of apolipoprotein A-I impairs exit of nascent apolipoprotein A-I from the endoplasmic reticulum
17. The carboxyl-terminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density lipoprotein
18. High yield overexpression and characterization of human recombinant proapolipoprotein A-I
19. Phospholipid binding and lecithin-cholesterol acyltransferase activation properties of apolipoprotein A-I mutants
20. Severe familial HDL deficiency in French-Canadian kindreds. Clinical, biochemical, and molecular characterization
21. Secretion of biologically active human proapolipoprotein A-I in a baculovirus-insect cell system: Protection from degradation by protease inhibitors
22. Antibodies to the carboxyl terminus of human apolipoprotein A-I. The putative cellular binding domain of high density lipoprotein 3 and carboxyl-terminal structural homology between apolipoproteins A-I and A-II
23. Studies on the formation, separation, and characterization of cyanogen bromide fragments of human AI apolipoprotein
24. Calculation of protein conformation from circular dichroism
25. Micellar complexes of human apolipoprotein A-I with phosphatidylcholines and cholesterol prepared from cholate-lipid dispersions
26. Defined apolipoprotein A-I conformations in reconstituted high density lipoprotein discs
27. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
28. Properties of an N-terminal proteolytic fragment of apolipoprotein AI in solution and in reconstituted high density lipoproteins
29. A rapid large-scale procedure for purification of lecithin-cholesterol acyltransferase from human and animal plasma
30. Efflux of intracellular vs plasma membrane cholesterol in HepG2 cells: Different availability and regulation by apolipoprotein A-I
31. Cholesterol transport between cells and high density lipoprotein subfractions from obese and lean subjects
32. A natural apolipoprotein A-I variant, apoA-I (L141R) Pisa, interferes with the formation of alpha-high density lipoproteins (HDL) but not with the formation of pre beta I-HDL and influences efflux of cholesterol into plasma
33. Two-dimensional electrophoresis of plasma lipoproteins: Recognition of new apo A-I-containing subpopulations
34. Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: Location of a PLTP binding domain in the amino terminal region of apoA-I
35. Efflux of cellular cholesterol and phospholipid to apolipoprotein A-I mutants
36. Structural and functional properties of full-length and truncated human proapolipoprotein AI expressed in Escherichia coli
37. Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein
38. Regulation of the concentration of pre beta high-density lipoprotein in normal plasma by cell membranes and lecithin-cholesterol acyltransferase activity
39. Kinetics versus thermodynamics in protein folding
40. The effect of deleting the propeptide from human preproapolipoprotein A-I on co-translational translocation and signal peptide processing
41. Apolipoprotein A-I domains involved in lecithin-cholesterol acyltransferase activation. Structure:Function relationships
42. Alteration in apolipoprotein A-I 22-mer repeat order results in a decrease in lecithin:Cholesterol acyltransferase reactivity
43. Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol
44. Pathway of cholesterol efflux from human hepatoma cells
45. Formation of new HDL particles from lipid-free apolipoprotein A-I
46. Apolipoprotein A-I-containing lipoproteins, with or without apolipoprotein A-II, as progenitors of pre-beta high-density lipoprotein particles
47. Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients
48. Plasma and fibroblasts of Tangier disease patients are disturbed in transferring phospholipids onto apolipoprotein A-I
49. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
50. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
51. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
52. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway
53. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport
54. Dissociation of lipid-free apolipoprotein A-I from high density lipoproteins
55. Cycling of apolipoprotein A-I between lipid-associated and lipid-free pools