HDL3-mediated inhibition of thrombin-induced platelet aggregation and fibrinogen binding occurs via decreased production of phosphoinositide- derived second messengers 1,2-diacylglycerol and inositol 1,4,5-tris- phosphate

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 6, 1998, Pages 861-869

  Nofer, Jerzy Roch ^a   Walter, Michael ^a   Kehrel, Beate ^b   Wierwille, Sonja ^b   Tepel, Martin ^c   Seedorf, Udo ^a   Assmann, Gerd ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b Medizinische Klinik und Poliklinik C   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Fibrinogen; High density lipoprotein; Platelet aggregation; Protein kinase C; Signal transduction

Indexed keywords

FIBRINOGEN; HIGH DENSITY LIPOPROTEIN; THROMBIN; 1,2-DIACYLGLYCEROL; CALCIUM; COAGULATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIACYLGLYCEROL; INOSITOL 1,4,5 TRISPHOSPHATE; LEUKOCYTE ANTIGEN; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN KINASE C;

ARTICLE; FIBRIN FORMATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; THROMBOSIS; ADULT; BIOSYNTHESIS; CELL MEMBRANE; DRUG EFFECT; ENZYME SPECIFICITY; INTRACELLULAR FLUID; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; THROMBOCYTE; THROMBOCYTE ACTIVATION; TIME;

ADULT; ANTIGENS, CD; BLOOD PLATELETS; CALCIUM; CELL MEMBRANE; COAGULANTS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIGLYCERIDES; FIBRINOGEN; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; INTRACELLULAR FLUID; LIPOPROTEINS, HDL; MIDDLE AGED; PHOSPHATIDIC ACIDS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION; PROTEIN KINASE C; SECOND MESSENGER SYSTEMS; SUBSTRATE SPECIFICITY; THROMBIN; TIME FACTORS;

EID: 0031595186     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.6.861     Document Type: Article

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