Immunotherapy with beta amyloid peptide as a potential treatment for Alzheimer's disease

NeuroScience News

Volumn 3, Issue 5, 2000, Pages 46-51

  Schenk, D ^a   Games, D ^a   Seubert, P ^a  

^a NONE

Author keywords

Alzheimer's disease; Antibodies; Beta amyloid; Transgenic mice; Treatment

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; CLINICAL TRIAL; DEMENTIA; DISEASE COURSE; DRUG SAFETY; HUMAN; IMMUNIZATION; IMMUNOTHERAPY; NONHUMAN; PATHOGENESIS; REVIEW; SENILE PLAQUE; TRANSGENIC MOUSE;

EID: 0033742544     PISSN: 10276599     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (13)

1. The neuropathological diagnosis of Alzheimer's disease: Clinical-pathological studies
2. New insights into the genetics of Alzheimer's disease
3. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology
4. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
5. Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice
6. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1
7. Reduction of beta-amyloid peptide 42 in the cerebrospinal fluid of patients with Alzheimer's disease
8. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
9. Purification and cloning of amyloid precursor protein beta-secretase from human brain
10. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
11. Beta-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE
12. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
13. The challenge of characterizing normal brain aging in relation to Alzheimer's disease