NMDA channel gating is influenced by a tryptophan residue in the M2 domain but calcium permeation is not altered

Biophysical Journal

Volumn 79, Issue 5, 2000, Pages 2454-2462

  Buck, D P ^a   Howitt, S M ^b   Clements, J D ^b  

^a Biology and Environment   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DIZOCILPINE; GLUTAMIC ACID; KETAMINE; LEUCINE; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRYPTOPHAN;

ACCELERATION; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CALCIUM CONDUCTANCE; CHANNEL GATING; CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; ION PERMEABILITY; PROTEIN CONFORMATION; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY;

EID: 0033738304     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(00)76488-5     Document Type: Article

References (28)

1. Ascher, P., and L. Nowak. 1988. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurons in culture. J. Physiol. 399:247-266.
2. Beck, C., L. P. Wollmuth, P. H. Seeburg, B. Sakmann, and T. Kuner. 1999. NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines. Neuron. 22:559-570.
3. Benveniste, M., and M. L. Mayer. 1995. Trapping of glutamate and glycine during open channel block of rat hippocampal neuron NMDA receptors by 9-aminoacridine. J. Physiol. 483:367-384.
4. Burnashev, N., H. Monyer, P. H. Seeburg, and B. Sakmann. 1992a. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit. Neuron. 8:189-198.
5. Burnashev, N., R. Schoepfer, H. Monyer, J. P. Ruppersberg, W. Gunther, P. H. Seeburg, and B. Sakmann. 1992b. Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science. 257:1415-1419.
6. Collingridge, G. L., and R. A. Lester. 1989. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 41:143-210.
7. Dingledine, R., R. I. Hume, and S. F. Heinemann. 1992. Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels. J. Neurosci. 12:4080-4087.
8. Ferrer-Montiel, A. V., W. Sun, and M. Montal. 1996. A single tryptophan on M2 of glutamate receptor channels confers high permeability to divalent cations. Biophys. J. 71:749-758.
9. Huettner, J. E., and B. P. Bean. 1988. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc. Natl. Acad. Sci. U.S.A. 85:1307-1311.
10. Iino, M., S. Ozawa, and K. Tsuzuki. 1990. Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. J. Physiol. 424:151-165.
11. Jonas, P., and N. Burnashev. 1995. Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels. Neuron. 15:987-990.
12. Kuner, T., L. P. Wollmuth, A. Karlin, P. H. Seeburg, and B. Sakmann. 1996. Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines. Neuron. 17:343-352.
13. Kutsuwada, T., N. Kashiwabuchi, H. Mori, K. Sakimura, E. Kushiya, K. Araki, H. Meguro, H. Masaki, T. Kumanishi, M. Arakawa, and et al. 1992. Molecular diversity of the NMDA receptor channel. Nature. 358:36-41.
14. Lester, R. A., J. D. Clements, G. L. Westbrook, and C. E. Jahr. 1990. Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature. 346:565-567.
15. Mayer, M. L., and G. L. Westbrook. 1987. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurons. J. Physiol. 394:501-527.
16. 2+ of NMDA responses in spinal cord neurones. Nature. 309:261-263.
17. Mayer, M. L., G. L. Westbrook, and L. Vyklicky, Jr. 1988. Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique. J. Neurophysiol. 60:645-663.
18. 2+-block site of the NMDA receptor channel. Nature. 358:673-675.
19. Moriyoshi, K., M. Masu, T. Ishii, R. Shigemoto, N. Mizuno, and S. Nakanishi. 1991. Molecular cloning and characterization of the rat NMDA receptor. Nature. 354:31-37.
20. Premkumar, L. S., and A. Auerbach. 1996. Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel. Neuron. 16:869-880.
21. Rosenmund, C., J. D. Clements, and G. L. Westbrook. 1993. Nonuniform probability of glutamate release at a hippocampal synapse. Science. 262:754-757.
22. Schneggenburger, R., and P. Ascher. 1997. Coupling of permeation and gating in an NMDA-channel pore mutant. Neuron. 18:167-177.
23. Schneggenburger, R., Z. Zhou, A. Konnerth, and E. Neher. 1993. Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron. 11:133-143.
24. Sharma, G., and C. F. Stevens. 1996. Interactions between two divalent ion binding sites in N-methyl-D- aspartate receptor channels. Proc. Natl. Acad. Sci. U.S.A. 93:14170-14175.
25. Stem, P., M. Cik, D. Colquhoun, and F. A. Stephenson. 1994. Single channel properties of cloned NMDA receptors in a human cell line: comparison with results from Xenopus oocytes. J. Physiol. 476:391-397.
26. 2+. Mol Pharmacol. 53:933-941.
27. 2+-permeable AMPA glutamate receptor channels. J. Gen. Physiol. 112:623-636.
28. Zarei, M. M., and J. A. Dani. 1994. Ionic permeability characteristics of the N-methyl-D-aspartate receptor channel. J. Gen. Physiol. 103: 231-248.