Effects of ethanol and of alcohol dehydrogenase inhibitors on the reduction of N-acetylaspartate levels of brain in mice in vivo: A search for substances that may have therapeutic value in the treatment of Canavan disease

Journal of Inherited Metabolic Disease

Volumn 23, Issue 7, 2000, Pages 684-692

  Baslow, M H ^a   Suckow, R F ^b   Hungund, B L ^b  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 PYRAZOLE 1 CARBOXAMIDINE; 4 METHYLPYRAZOLE; 4 PYRAZOLECARBOXYLIC ACID; ACAMPROSATE; ALCOHOL; ALCOHOL DEHYDROGENASE INHIBITOR; CYCLOSPORIN; CYSTEIC ACID; GANGLIOSIDE GM1; GLUTARIC ACID DERIVATIVE; HARMALINE; HARMINE; HOMOTAURINE; N ACETYLASPARTIC ACID; OXIDOREDUCTASE INHIBITOR; PYRAZOLE 3,5 DICARBOXYLIC ACID; PYRAZOLE DERIVATIVE; RESERPINE; SUCCINIC ACID DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BRAIN LEVEL; CANAVAN DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; IN VIVO STUDY; MALE; MOUSE; NONHUMAN;

ALCOHOL DEHYDROGENASE; ANIMALS; ASPARTIC ACID; BRAIN; CANAVAN DISEASE; ENZYME INHIBITORS; ETHANOL; MALE; MICE; PYRAZOLES;

EID: 0033736818     PISSN: 01418955     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005618526988     Document Type: Article

References (26)

1. Epileptic seizures induced by N-acetyl-L-aspartate in rats: In vivo and in vitro studies
2. Function of the N-acetyl-L-histidine system in the vertebrate eye. Evidence in support of a role as a molecular water pump
3. The existence of molecular water pumps in the nervous system. A review of the evidence
4. Molecular water pumps and the etiology of Canavan disease; a case of the sorcerer's apprentice
5. Canavan disease: Analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms
6. Molecular water pumps in the central nervous system and their role in neuropathology
7. Expression of aspartoacylase activity in cultured rat macroglial cells is limited to oligodendrocytes
8. Central effects of acamprosate: Acamprosate modifies the brain in-vivo proton magnetic resonance spectrum in healthy young male volunteers
9. The participation of N-acetyl-L-aspartic acid in brain metabolism
10. Changes in the diffusion of water and intracellular metabolites after excitotoxic injury and global ischemia in neonatal rat brain
11. Ethylene glycol poisoning in a child treated with 4-methylpyrazole
12. MRI and MRS studies on acute effects of ethanol in the rat brain
13. Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat, a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system
14. Biological water and its role in the effects of alcohol
15. Global CNS gene transfer for a childhood neurogenetic enzyme deficiency: Canavan disease
16. Neurochemical adaptation to cocaine abuse: Reduction of N-acetyl aspartate in thalamus of human cocaine abusers
17. Decrease of N-acetylaspartate after ACTH therapy in patients with infantile spasms
18. Knock-out mouse for Canavan disease: A model for gene transfer to the central nervous system
19. Function of N-acetyl aspartic acid in the brain: Effects of certain drugs
20. Studies on the function of N-acetyl aspartic acid in brain
21. +-glucose cotransporter is a molecular water pump
22. Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy
23. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
24. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury
25. 1H nuclear magnetic resonance spectroscopy and biochemical characterization