The potential of Lps(d)/Ran cDNA in gene therapy for septic shock

Journal of Hematotherapy and Stem Cell Research

Volumn 9, Issue 5, 2000, Pages 629-634

  Wong, P M C ^a   Sultzer, B M ^b   Chung, S W ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Stem Cell Therapeutics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GENE PRODUCT; LIPOPOLYSACCHARIDE; RAN PROTEIN; UNCLASSIFIED DRUG;

CYTOKINE PRODUCTION; GENE EXPRESSION; GENE MUTATION; GENE THERAPY; HUMAN; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

ANIMALS; BACTERIAL PROTEINS; DNA, COMPLEMENTARY; GENE THERAPY; HUMANS; LIPOPOLYSACCHARIDES; MANNOSYLTRANSFERASES; RAN GTP-BINDING PROTEIN; SHOCK, SEPTIC; SIGNAL TRANSDUCTION;

EID: 0033731550     PISSN: 15258165     EISSN: None     Source Type: Journal    
DOI: 10.1089/15258160050196669     Document Type: Review

References (69)

1. Endotoxin, sepsis and the primose path
2. The value of animal models in the development of new drugs for the treatment of the sepsis syndrome
3. Treatment of endotoxic shock: Glucocorticoids, lazaroids, nonsteroidals, others
4. Divergent efficacy of antibody to tumor necrosis factor-α in intravascular and peritonitis models of sepsis
5. Pentoxifylline attenuates neutrophil activation in experimental endotoxemia in chimpanzees
6. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees
7. Cytokine appearance in human endotoxemia and primate bacteremia
8. Detection of circulating tumor necrosis factor after endotoxin administration
9. Peripheral blood leukocyte kinetics following in vivo lipopolysaccharide (LPS) administration to normal human subjects: Influence of elicited hormones and cytokines
10. Experimental endotoxemia in humans: Analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
11. Detection of interleukin 8 and tumor necrosis factor in normal humans after intravenous endotoxin: The effect of anti-inflammatory agents
12. Pretreatment with ibuprofen augments circulating tumor necrosis factor-alpha, interleukin-6, and elastase during acute endotoxinemia
13. Recombinant bovine somatotropin blunts plasma tumor necrosis factor-alpha, cortisol, and thromboxane-B2 responses to endotoxin in vivo
14. Increased circulating cytokines, cytokine antagonists, and E-selectin after intravenous administration of endotoxin in humans
15. Shock and tissue injury induced by recombinant human cachectin
16. Proctor RA: Lipopolysaccharide, but not lethal infection, releases tumor necrosis factor in mice
17. Activation of coagulation after administration of tumor necrosis factor to normal subjects
18. Effects on leukocytes after injection of tumor necrosis factor into healthy humans
19. In vivo inflammatory activity of epidermal cell-derived thymocyte activating factor and recombinant interleukin I in the mouse
20. Provocation of pulmonary vascular endothelial injury in rabbits by human recombinant interleukin-I beta
21. Interleukin-1-induced anorexia in the rat. Influence of prostaglandins
22. Interleukin I trials in cancer patients: A review of the toxicity, antitumor and hematopoietic effects
23. Association between tumor necrosis factor in serum and fatal outcome in patients with meningococcal disease
24. The complex pattern of cytokines in serum from patients with meningococcal septic shock: Association between interleukin 6, interleukin 1, and fatal outcome
25. Plasma tumor necrosis factor and mortality in critically ill septic patients
26. Circulating interleukin-1β and tumor necrosis factor-a concentrations after burn injury in humans
27. Plasma proinflammatory cytokine concentrations. Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit
28. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk
29. Swiss-Dutch J5 Immunoglobulin Study Group: Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-a, and interferon-gamma in the serum of patients with septic shock
30. Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans
31. Dissociation between plasma and monocyte-associated cytokines during sepsis
32. Restoration of lipopolysaccharide-mediated B-cell response after expression of a c-DNA encoding a GTE-binding protein
33. A GTPase controlling nuclear trafficking: Running the right way or walking RAN-domly?
34. Whose finger is on the switch?
35. A G protein involved in nucleocytoplasmic transport: The role of Ran
36. Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran
37. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran
38. Lps/Ran of endotoxin-resistant C3H/HeJ inbred mice is defective in lipopolysaccharide response
39. The destinies and destinations of RNAs
40. Determinants of mRNA localization
41. Mutational analysis of a RNA recognition element that mediates localization of bicoid mRNA
42. Staufen protein associates with the 3'UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner
43. ex1 protein specifically binds BLE1, a bicoid mRNA localization element, and is required for one phase of its activity
44. Two copies of a subelement from the Vg1 RNA localization sequence are sufficient to direct vegetal localization in Xenopus oocytes
45. A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates
46. RNA-binding protein conserved in both microtuble, and microfilament-based RNA localization
47. Characterization of a beta-actin mRNA zipcode-binding protein
48. Sequences responsible for intracellular localization beta-actin messenger RNA also affect cell phenotype
49. Sorting of beta-actin mRNA and protein to neurites and growth cones in culture
50. Down-regulation of Endotoxin-induced TNFα production by Lps(d)/Ran
51. The inhibition of the mitogenic stimulation of B lymphocytes by a serine protease inhibitor: Commitment to proliferation correlates with an enhanced expression of a cell-associated arginine specific serine enzyme
52. Partial restoration of the lipopolysaccharide-induced proliferative response in splenic B cells from C3H/HeJ mice
53. Paradoxical preservation of a lipopolysaccharide response in C3H/HeJ macrophages: Induction of matrix metalloproteinase-9
54. The Dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in drosophila adults
55. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
56. A family of human receptors structurally related to Drosophila Toll
57. Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL: Evidence for a multi-gene receptor family in humans
58. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 Gene
59. Cutting Edge: Functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lps(n) gene: In vivo evidence for a dominant negative mutation
60. Phylogenetic perspectives in innate immunity
61. Unresponsiveness of MyD88-deficient mice to endotoxin
62. The toll of innate immunity on microbial pathogens
63. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
64. Toll-like receptor 2 mediates lipopolysaccharide-induced cellular signaling
65. Cell activation and apoptosis by bacterial lipoproreins through Toll-like receptor-2
66. Tlr-4-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for Tlr4 as the Lps gene product
67. Gene expression of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differentially regulated in mouse T lymphocytes
68. Peptidoglycan and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
69. Genes, receptors, signals and responses to lipopolysaccharide endotoxin