Kinetics and selectivity of mechanism-based inhibition of guinea pig hepatic and pulmonary cytochrome P450 by N-benzyl-1-aminobenzotriazole and N- α-methylbenzyl-1-aminobenzotriazole

Drug Metabolism and Disposition

Volumn 24, Issue 9, 1996, Pages 996-1001

  Sinal, Christopher J ^a   Bend, John R ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTRIAZOLE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; ENZYME INHIBITOR; ETHOXYRESORUFIN DEETHYLASE; N (ALPHA METHYLBENZYL) 1 AMINOBENZOTRIAZOLE; N BENZYL 1 AMINOBENZOTRIAZOLE; PENTOXYRESORUFIN; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMETHYLATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; GUINEA PIG; HALF LIFE TIME; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; GUINEA PIGS; ISOENZYMES; KINETICS; LIVER; LUNG; MALE; NADP; OXAZINES; TRIAZOLES;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0029809857     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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