In vitro systems as simulations of in vivo conditions: The study of cognition and synaptic plasticity in neurotoxicology

Annals of the New York Academy of Sciences

Volumn 919, Issue , 2000, Pages 119-132

  Gilbert, M E ^a,b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYGDALOID NUCLEUS; CENTRAL NERVOUS SYSTEM DEPRESSION; COGNITION; CONDITIONING; CONFERENCE PAPER; EYELID REFLEX; FEAR; HUMAN; LEARNING; LONG TERM POTENTIATION; MEMORY; NERVE CELL PLASTICITY; NEUROCHEMISTRY; NEUROTOXICOLOGY; NONHUMAN; SIMULATION; SPATIAL MEMORY;

EID: 0033711413     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06874.x     Document Type: Conference Paper

References (81)

1. Low-level lead exposure and children's cognitive function in the preschool years
2. Neurobehavioral toxicology of organic solvents
3. Intellectual impairment in children exposed to polychlorinated biphenyls in utero
4. Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age
5. Cognitive, neural, behavioral effects of low-level lead exposure
6. Hippocampus, space, and memory
7. Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans
8. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
9. A synaptic model of memory: Long-term potentiation in the hippocampus
10. Long-term potentiation - A decade of progress?
11. Long-term potentiation and learning
12. Activity dependent modulation of hippocampal synaptic efficacy: Some implications for memory processes
13. Long-term potentiation phenomena in the rat limbic forebrain
14. The mechanism of expression of long-term enhancement of hippocampal synapses: Current issues and theoretical implications
15. Cellular and molecular bases of memory: Synaptic and neuronal plasticity
16. Analysis of the decremental nature of LTP in the dentate gyrus
17. Chronic developmental lead exposure accelerates decay of long-term potentiation in rat dentate gyrus in vivo
18. Induction of fos-like immunoreactivity and the maintenance of long-term potentiation in the dentate gyrus of unanesthetized rats
19. Anatomy and electrophysiology of fast central synapses lead to a structural model for long-term potentiation
20. Synapse restructuring associated with the maintenance phase of hippocampal long-term potentiation
21. The nature and causes of hippocampal long-term potentiation
22. GAP-43: An intrinsic determinant of neuronal development and plasticity
23. RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes
24. Memory formation: The sequence of biochemical events in the hippocampus and its connection to activity in other brain structures
25. Protein kinases: Which one is the memory molecule?
26. Long-term potentiation and synaptic protein phosphorylation
27. Molecular, cellular, and neuroanatomical substrates of place learning
28. Phosphorylation of non-NMDA glutamate receptor ion channels: Implications for synaptic plasticity and their membrane topology
29. The mechanism of induction of NMDA receptor-dependent long-term potentiation in the hippocampus
30. NMDA receptors - Their role in long-term potentiation
31. Triggers and substrates of hippocampal synaptic plasticity
32. The role of postsynaptic calcium in the induction of long-term potentiation
33. 2+ signaling requirements for long-term depression in the hippocampus
34. Low-frequency trains of paired stimuli induce long-term depression in area CA1, but not in dentate gyrus of the intact rat
35. Long-term depression
36. Long-term depression of synaptic transmission in the cerebellum: Cellular and molecular mechanisms revisited
37. Calcium: A trigger for long-term depression and potentiation in the hippocampus
38. Long-term synaptic depression
39. Operational principles of hippocampal neurons
40. Patterns of activation in a monosynaptic cortical pathway: The perforant path to the dentate area of the hippocampal formation
41. Distinct components of spatial learning revealed by prior training and NMDA receptor blockade
42. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro
43. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
44. Synaptic plasticity and learning: Selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate antagonist AP5
45. Pharmacological and genetic approaches to the analysis of tyrosine kinase function in long-term potentiation
46. Metabotropic glutamate receptors in hippocampal long-term potentiation and learning and memory
47. Delay-dependent impairment of a matching-to-place task with chronic intrahippocampal infusion of the NMDA-antagonist, D-AP5
48. Correlation between pharmacology of long-term potentiation and the pharmacology of memory
49. Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain
50. Memory and behavior: A second generation of genetically modified mice
51. Long-term potentiation: What's learning got to do with it?
52. Involvement of LTP in memory: Are we 'searching under the street light'?
53. Why NMDA-receptor-dependent long-term potentiation may not be a mechanism of learning and memory: Reappraisal of the NMDA-receptor blockade strategy
54. LTP and memory: Deja vu
55. Associative learning
56. Organization of memory traces in the mammalian brain
57. Long-term potentiation in the interpositus and vestibular nuclei in the rat
58. Intracellular correlates of acquisition and long-term memory of classical conditioning in Purkinje cell dendrites in slices of rabbit cerebellar lobule HVI
59. The role of the amygdala in fear and anxiety
60. Synaptic transmission and plasticity in the amygdala: An emerging physiology of fear conditioning circuits
61. Acquisition of contextual Pavlovian fear condition is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala
62. Fear conditioning induces a lasting potentiation of synaptic currents in vitro
63. Fear conditioning induces associative long-term potentiation in the amygdala
64. Assessment techniques for detecting neurobehavioral toxicity
65. Neurotoxicant-induced changes in schedule-controlled behavior
66. Effects of maternal lead exposure on functional plasticity in the visual cortex and hippocampus of immature rats
67. Inhibition of long-term potentiation in developing rat visual cortex, but not hippocampus by in utero exposure to polychlorinated biphenyls
68. Maternal exposure to polychlorinated biphenyls inhibits long-term potentiation in the visual cortex of adult rats
69. Towards the development of a biologically-based dose-response model for lead neurotoxicity
70. Developmental exposure to a complex PCB mixture (Aroclor 1254) produces a persistent impairment in long-term potentiation in the dentate gyrus in vivo
71. Alterations in synaptic transmission and plasticity in hippocampus by a complex PCB mixture Aroclor 1254
72. The influence of developmental period of lead exposure on long-term potentiation in the rat dentate gyrus in vivo
73. Chronic developmental lead exposure impairs hippocampal long-term potentiation in vivo: A dose-response analysis
74. PCBs reduce long-term potentiation in the CA1 region of rat hippocampus
75. Prenatal exposure to moderate levels of ethanol can have long-lasting effects on hippocampal synaptic plasticity in adult offspring
76. Ortho-substituted 2,2',3,5',6-pentachlorobiphenyl (PCB 95) alters rat hippocampal ryanodine receptors and neuroplasticity in vitro: Evidence for altered hippocampal function
77. Prenatal and postnatal chronic exposure to low levels of inorganic lead attenuates long-term potentiation in the adult rat hippocampus in vivo
78. A disconnection between spatial learning and LTP in young rats chronically exposed to lead
79. Developmental lead (Pb) exposure fails to disrupt spatial learning in the Morris water maze