Alterations in synaptic transmission and plasticity in hippocampus by a complex PCB mixture, Aroclor 1254

Neurotoxicology and Teratology

Volumn 20, Issue 4, 1998, Pages 383-389

  Gilbert, M E ^a,b,c,d   Liang, D ^b  

^a National Research Council   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c The University of North Carolina at Chapel Hill   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Aroclor 1254; CA1; Hippocampus; Long term potentiation (LTP); Neuroplasticity; Polychlorinated biphenyls (PCB); Synaptic transmission

Indexed keywords

AROCLOR 1254; POLYCHLORINATED BIPHENYL; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; HIPPOCAMPUS; IN VITRO STUDY; LONG TERM POTENTIATION; MALE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

ANIMALS; AROCLOR 1254; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; RATS; RATS, LONG-EVANS; SYNAPTIC TRANSMISSION;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0031828908     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0892-0362(98)00005-1     Document Type: Article

References (28)

1. Altmann, L.; Weinand-Haerer, A.; Lilienthal, H.; Wiegand, H.: Maternal exposure to polychlorinated biphenyls inhibits long-term potentiation in the visual cortex of adult rats. Neurosci. Lett. 202:53-56; 1995.
2. Andersen, P.; Sundbert, S. H.; Sveen, O.; Swann, J. W.; Wigstrom, H.: Possible mechanisms for long-lasting potentiation of synaptic transmission in hippocampal slices from guinea pigs. J. Physiol. 302:463-482; 1980.
3. Bliss, T. V. P.; Collingridge, G. L.: A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361:31-33; 1993.
4. Chen, Y.-C.; Guo, Y.-L.; Hsu, C.-C.; Rogan, W. J.: Cognitive development of Yu-Cheng (Oil Disease) children prenatally exposed to heat-degraded PCBs. J. Am. Med. Assoc. 268:3213-3218; 1992.
5. Chen, Y.-J.; Hsu, C.-C.: Effects of prenatal exposure to PCBs on the neurological function of children: A neuropsychological and neurophysiological study. Dev. Med. Child Neurol. 36:312-320; 1994.
6. Colborn, T.; vom Saal, F. S.; Soto, A. M.: Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 101:378-384; 1993.
7. Eriksson, P.; Lundkvist, U.; Fredriksson, A.: Neonatal exposure to 3,3′,4,4′-tetrachlorobiphenyl: Changes in spontaneous behavior and cholinergic muscarinic receptors in adult mouse. Toxicology 69:27-34; 1991.
8. Gilbert, M. E.; Mack, C. M.; Crofton, K. M.: Developmental exposure to polyhalogenated hydrocarbons alters hippocampal physiology and plasticity in the rat. Health Conference '97 -Great Lakes/St. Lawrence, Montreal, P.Q., Canada; 1997.
9. Goldey, E. S.; Kehn, L. S.; Lau, C.; Rehnberg, G. L.; Crofton, K. M.: Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats. Toxicol. Appl. Pharmacol. 135:77-88; 1995.
10. Jacobson, J. L.; Jacobson, S. W.; Humphrey, H. E. B.: Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J. Pediatr. 116:38-45; 1990.
11. Jacobson, J. L.; Jacobson, S. W.; Padgett, R. J.; Brumitt, G. A.; Billings, R. L.: Effects of prenatal PCB exposure on cognitive processing efficiency and sustained attention. Dev. Psychol. 28:297-306; 1992.
12. Jansen, H. T.; Cooke, P. S.; Porcelli, J.; Liu, T.-C.; Hansen, L. G.: Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and in vivo studies. Reprod. Toxicol. 7:237-248; 1993.
13. Kodavanti, P. R. S.; Shafer, T. J.; Ward, T. R.; Mundy, W. R.; Freudenrich, T.; Harry, G. J.; Tilson, H. A.: Differential effects of polychlorinated biphenyl congeners on phosphoinositide hydrolysis and protein kinase C translocation in rat cerebellar granule cells. Brain Res. 662:75-82; 1994.
14. Kodavanti, P. R. S.; Shin, D.-S.; Tilson, H. A. T.; Harry, G. J.: Comparative effects of two polychlorinated biphenyl congeners on calcium homeostasis in rat cerebellar granule cells. Toxocol. Appl. Pharmacol. 123:97-106; 1993.
15. +2-sequestration in rat cerebellum by polychlorinated biphenyl mixtures and congeners: Structure-activity relationships. Arch. Toxicol. 70:150-157; 1996.
16. Lilienthal, H.; Neuf, M.; Munoz, C.; Winneke, G.: Behavioral effects of pre and postnatal exposure to a mixture of low chlorinated PCBs in rats. Fundam. Appl. Toxicol. 15:457-467; 1990.
17. Lomo, T.: Patterns of activation in a monosynaptic cortical pathway: The perforant path input to the dentate area of the hippocampal formation. Exp. Brain Res. 12:18-45; 1971.
18. Malenka, R. C.; Kauer, J. A.; Perkel, D. J.; Nicoll, R. A.: Long-term potentiation in the hippocampus. Prog. Cell Res. 1:263-277; 1990.
19. McNaughton, B. L.: The mechanism of expression of long-term enhancement of hippocampal synapses: Current issues and theoretical implications. Annu. Rev. Physiol. 55:375-396; 1993.
20. Schantz, S. L.; Levin, E. D.; Bowman, R. E.: Long-term neurobehavioral effects of perinatal PCB exposure in monkeys. J. Environ. Toxicol. Chem. 10:747-756; 1991.
21. Schantz, S. L.; Levin, E. D.; Bowman, R. E.; Heironimus, M. P.; Laughlin, N. K.: Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys. Neurotoxicol. Teratol. 11:243-250; 1989.
22. Schantz, S. L.; Moshtaghian, J.; Ness, D. K.: Spatial learning deficits in adult rats exposed to ortho-substituted PCB congeners during gestation and lactation. Fundam. Appl. Toxicol. 26:117-126; 1995.
23. Seegal, R. F.; Bush, B.; Borsch, K. O.: Subchronic exposure of the adult rat to Aroclor 1254 yields regionally specific changes in central dopaminergic function. Neurotoxicology 12:55-66; 1991.
24. Seegal, R. F.; Bush, B.; Shain, W.: Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture. Toxicol. Appl. Pharmacol. 106:136-144; 1990.
25. Seo, B. W.; Gilbert, M. E.; Mack, C. M.; Medora, K.; Crofton, K. M.; Schantz, S. L.: Effects of maternal exposure to Aroclor 1254 on spatial learning and in vivo long-term potentiation. Toxicological Sciences 42:35; 1998.
26. Squire, L. R.: Memory and the hippocampus: A synthesis from findings with rats, monkeys and humans. Psychol. Rev. 99:195-231; 1992.
27. Traube, J. S.; Schwartzkroin, P. A.: Mechanisms of long-term potentiation:EPSP/Spike dissociation, intradendritic recordings, and glutamate sensitivity. J. Neurosci. 8:1632-1644; 1988.
28. Wong, P. W.; Joy, R. M.; Albertson, T. E.; Schantz, S. L.; Pessah, I. N.: Ortho-substituted 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) alters rat hippocampal ryanodine receptors and neuroplasticity in vitro: Evidence of altered hippocampal function. Neurotoxicology 18:443-456; 1997.