Analysis of the tumor vasculature and metastatic behavior of xenografts of human melanoma cell lines transfected with vascular permeability factor

American Journal of Pathology

Volumn 148, Issue 4, 1996, Pages 1203-1217

  Pötgens, Andy J G ^a,c   Van Altena, Margarethe C ^a   Lubsen, Nicolette H ^b   Ruiter, Dirk J ^a   De Waal, Robert M W ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c CENTRAL LABORATORY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; DNA TRANSFECTION; HUMAN; HUMAN CELL; LUNG METASTASIS; MELANOMA CELL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; RNA TRANSLATION; TUMOR GROWTH; XENOGRAFT;

ANIMALS; CAPILLARY PERMEABILITY; CELL DIVISION; ENDOTHELIAL GROWTH FACTORS; HUMANS; LYMPHOKINES; MELANOMA; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; PROTEIN BIOSYNTHESIS; RECOMBINANT PROTEINS; RNA, MESSENGER; SKIN NEOPLASMS; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0029923104     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 1990, 82:4-6
2. Blood CH, Zetter BR. Tumor interactions with the vasculature: angiogenesis and tumor metastasis. Biochim Biophys Acta 1990, 1032:89-118
3. Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation Cell 1991, 64:327-336
4. Weidner N, Semple JP, Welch WR, Folkman J: Tumor angiogenesis and metastasis- correlation in invasive breast carcinoma. N Engl J Med 1991, 324:1-8
5. Horak ER, Leek R, Klenk N, Lejeune S, Smith K, Stuart N, Greenall M, Stepniewska K, Harris AL Angiogenesis, assessed by platelet/endothelial cell adhesion molecule Ab, as indicator of node metastases, and survival in breast cancer Lancet 1992, 340.1120-1124
6. Macchiarini P, Fontanini G, Hardin MJ, Squartini F, Angeletti CA Relation of neovascularisation to metastasis of non-small-cell lung cancer. Lancet 1992, 340: 145-146
7. Barnhill RL, Fandrey K, Levy MA, Mihm MC, Hyman B: Angiogenesis and tumor progression of melanoma. Quantification of vascularity in melanocytic nevi and cutaneous malignant melanoma. Lab Invest 1992, 67. 331-337
8. Olivarez D, Ulbricht T, DeRiese W, Foster R, Reister T, Einhorn L, Sledge G: Neovascularization in clinical stage A testicular germ cell tumor: prediction of metastatic disease. Cancer Res 1994, 54:2800-2802
9. Jain RK: Determinants of tumor blood flow: a review. Cancer Res 1988, 48:2641-2658
10. Vaupel V, Kallinowski F, Okunieff P: Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989, 49. 6449-6465
11. Heuser LS, Miller FN: Differential macromolecular leakage from the vasculature of tumors. Cancer 1986, 57. 461-464
12. Dvorak HF, Nagy JA, Dvorak JT, Dvorak AM: Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol 1988, 133 95-109
13. Shockley TR, Lin K, Nagy JA, Tompkins RG, Yarmush ML, Dvorak HF. Spatial distribution of tumor-specific mAb in human melanoma xenografts Cancer Res 1992, 52 367-376
14. Rickles FR, Edwards RL, Barb C, Cronlund M: Abnormalities of blood coagulation in patients with cancer. Cancer 1983, 51.301-307
15. Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992, 267:10931-10934
16. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VN, Einer SQ, Strieter RM: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 1992, 258:1798-1801
17. Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei K-J, Chou JY, Persico MG: Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PIGF), are transcribed from a single gene of chromosome 14. Oncogene 1993, 8:925-931
18. Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N: Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 1993, 362:841-846
19. Kondo S, Asano M, Suzuki H Significance of vascular endothelial growth factor/vascular permeability factor for solid tumor growth, and its inhibition by the Ab. Biochem Biophys Res Commun 1993, 194:1234-1241
20. Millauer B, Shawver LK, Plate KH, Risau W, Ullrich A: Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 1994, 367:576-579
21. Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989, 246 1306-1309
22. Peters KG, De Vries C, Williams LT: Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggest a role in endothelial differentiation and blood vessel growth. Proc Natl Acad Sci USA 1993, 90:8915-8919
23. Quinn TP, Peters KG, De Vries C, Ferrara N, Williams LT. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA 1993, 90.7533-7537
24. Millauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Moller NPH, Risau W, Ullrich A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993, 72:835-846
25. Barleon B, Hauser S, Schollmann C, Weindel K, Marmé D, Yayon A, Weich HA: Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells. J Cell Biochem 1994, 54:56-66
26. Pepper MS, Ferrara N, Orci L, Montesano R: Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells Biochem Biophys Res Commun 1991, 181:902-906
27. Unemori EN, Ferrara N, Bauer EA, Amento EP. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J Cell Physiol 1992, 153.557-562
28. Koch AE, Harlow LA, Haines GK, Amento EP, Unemori EN, Wong WL, Pope RM, Ferrara N. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J Immunol 1994, 152: 4149-4156
29. Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983, 219 983-985
30. Keck PJ, Hauser SD, Krivi G, Sanzo K, Warren T, Feder J, Connolly DT. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989, 246 1309-1312
31. Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC, Pan YCE, Olander JV, Connolly DT, Stern D: Vascular permeability factor a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration J Exp Med 1990, 172:1535-1545
32. Senger DR, Van De Water L, Brown LF, Nagy JA, Yeo K-T, Yeo T-K, Berse B, Jackman RW, Dvorak AM, Dvorak HF: Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev 1993, 12.303-324
33. Pötgens AJG, Lubsen NH, van Altena MC, Schoenmakers JGG, Ruiter DJ, de Waal RMW Vascular permeability factor expression influences tumor angiogenesis in human melanoma lines xenografted to nude mice Am J Pathol 1995, 146.197-209
34. Van Muijen GNP, Cornelissen LMHA, Jansen CFJ, Figdor CG, Johnson JP, Bröcker EB, Ruiter DJ. Antigen expression of metastasizing and non-metastasizing human melanoma cells xenografted into nude mice Clin & Exp Metastasis 1991, 9:259-272
35. Mosmann T: Rapid colorimetric assay for cellular growth and survival- application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63
36. Canfield V, Emanuel JR, Spickofski N, Levenson R, Margolskee RF Ouabain-resistant mutants of rat Na,K-ATPase α2 isoform identified by using an episomal expression vector. Mol Cell Biol 1990, 10:1367-1372
37. Peek R, Van der Logt P, Lubsen NH, Schoenmakers JGG: Tissue- and species-specific promoter elements of rat γ-crystallin genes. Nucleic Acids Res 1990, 18: 1189-1197
38. Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning. A Laboratory Manual, ed 2 Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1989
39. Pötgens AJG, Lubsen NH, van Altena G, Schoenmakers JGG, Ruiter DJ, de Waal RMW: Measurement of tissue factor messenger RNA levels in human endothelial cells by a quantitative RT-PCR assay. Thromb Haemostasis 1994, 71.208-213
40. Pötgens AJG, Lubsen NH, van Altena MC, Vermeulen R, Bakker A, Schoenmakers JGG, Ruiter DJ, de Waal RMW: Covalent dimenzation of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity: evidence from Cys to Ser mutations. J Biol Chem 1994, 269.32879-32885
41. Vecchi A, Garlanda C, Lampugnani MG, Resnati M, Matteucci C, Stoppacciaro A, Schnurch H, Risau W, Ruco L, Mantovani A, Dejana E. MAb specific for endothelial cells of mouse blood vessels their application in the identification of adult and embryonic endothehum Eur J Cell Biol 1994, 63.247-254
42. Houck KA, Ferrara IM, Winer J, Cachianes G, Li B, Leung DW The vascular endothelial growth factor family identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 1991, 5:1806-1814
43. Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. Dual regulation of vascular permeability factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 1992, 267 26031-26037
44. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA: The human gene for vascular endothelial growth factor Multiple protein forms are encoded through alternative exon splicing J Biol Chem 1991, 266 11947-11954
45. Dvorak HF, Sioussat TM, Brown LF, Berse B, Nagy JA, Sotrel A, Manseau EJ, Van De Water L, Senger DR Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors concentration in tumor blood vessels J Exp Med 1991, 174.1275-1278
46. Rao CD, Pech M, Robbins KC, Aaronson SA: The 5′ untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor Mol Cell Biol 1988, 8 284-292
47. Ratner L, Thielan B, Collins T: Sequences of the 5′ portion of the human c-sis gene, characterization of the transcriptional promoter and regulation of expression of the protein product by 5′ untranslated mRNA sequences Nucleic Acids Res 1987, 15.6017-6036
48. Zhang H-T, Craft P, Scott PAE, Ziehe M, Weich HA, Harris AL, Bicknell R: Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J Natl Cancer Inst 1995, 87:213-219