Gene therapy, factor VIII antibodies and immune tolerance: Hopes and concerns

Haematologica

Volumn 85, Issue 10 SUPPL., 2000, Pages 108-112

  Lillicrap, D ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Factor VIII; Gene therapy; Inhibitors

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 8 INHIBITOR; BLOOD CLOTTING FACTOR 8;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; CONFERENCE PAPER; GENE MUTATION; GENE TARGETING; GENE THERAPY; HEMOPHILIA A; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; TRANSGENE; ANIMAL; GENETICS; HUMAN; IMMUNOLOGY; METHODOLOGY; REVIEW;

ANIMALS; FACTOR VIII; GENE THERAPY; HEMOPHILIA A; HUMANS; IMMUNE TOLERANCE;

EID: 0033678880     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (11)

1. Haemophilia A: Mutation type determines risk of inhibitor formation
2. Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII deficient mice
3. Transduction of dendritic cells by DNA viral vectors directs the immune response to transgene products in muscle fibers
4. Use of a liver-specific promoter reduces immune responses to the transgene in adenoviral vectors
5. Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII
6. A four year update of safety and efficacy of an albumin-free formulated, B-domain deleted factor VIII (BBDrFVIII, r-VIII SQ) in previously untreated severe hemophilia A patients
7. Safety and efficacy of an albumin-free formulated, B-domain deleted recombinant factor VIII (BBDrFVIII, r-VIII SQ) in previously treated patients (PTPs) [abstract]. A four year update
8. Biochemical and functional characterization of myotube synthesized factor IX
9. Tolerance, danger and the extended family
10. Adenoviral vectors for the treatment of hemophilia A
11. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector