Gastrin, growth, and colon neoplasia

Gut

Volumn 47, Issue 6, 2000, Pages 747-748

  Dockray, G J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; GASTRIN; PROGASTRIN;

COLON CANCER; GRAM NEGATIVE INFECTION; HELICOBACTER; HUMAN; NOTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

COLONIC NEOPLASMS; GASTRIN-SECRETING CELLS; GASTRINS; HUMANS; RECEPTOR, CHOLECYSTOKININ B; RECEPTORS, CHOLECYSTOKININ;

EID: 0033671371     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.6.747     Document Type: Note

References (11)

1. Regulation of gastrointestinal mucosal growth
2. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
3. Gastrin and gastrin receptor activation - An early event in the adenoma carcinoma sequence
4. Processing and proliferative effects of human progastrin in transgenic mice
5. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
6. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line
7. Discrimination between temperature- and brefeldin A-sensitive steps in the sulfation, phosphorylation, and cleavage of progastrin and its derivatives
8. Oncogenic ras induces gastrin gene expression in colon cancer
9. Gastrin is a downstream target of the β-cantenin/TCF-4 signaling pathway which mediates growth in the APC(min-/+) mouse model of intestinal polyposis
10. Progastrin expression predisposes mice to development of colon carcinomas and adenomas in response to AOM
11. Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM