Gα(S)-induced neurodegeneration in Caenorhabditis elegans

Journal of Neuroscience

Volumn 18, Issue 8, 1998, Pages 2871-2880

  Berger, Allison J ^a   Hart, Anne C ^a,c   Kaplan, Joshua M ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

Caenorhabditis elegans; CAMP; Cell death; G protein; Mutant; Necrosis; Neurodegeneration; Signal transduction

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; ACY 1 PROTEIN, C ELEGANS; ACY-1 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN;

ARTICLE; CAENORHABDITIS ELEGANS; CELL LOSS; CELL SWELLING; GENE MUTATION; LARVAL DEVELOPMENT; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; ANIMAL BEHAVIOR; APOPTOSIS; CYTOLOGY; ENZYMOLOGY; ESCAPE BEHAVIOR; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NECROSIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY NERVE CELL;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CYCLIC AMP; ESCAPE REACTION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; MOLECULAR SEQUENCE DATA; MUTATION; NECROSIS; NERVE DEGENERATION; NEURONS, AFFERENT; SIGNAL TRANSDUCTION;

EID: 0032521673     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-08-02871.1998     Document Type: Article

References (72)

1. Attwell D, Barbour B, Szatkowski M (1993) Nonvesicular release of neurotransmitter. Neuron 11:401-407.
2. Avery L (1993) The genetics of feeding in C. elegans. Genetics 133:897-917.
3. Bargmann CI, Thomas JH, Horvitz HR (1990) Chemosensory cell function in the behavior and development of Caenorhabditis elegant. Cold Spring Harb Symp Quant Biol 55:529-538.
4. Ben-Ari Y (1985) Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 14:375-403.
5. Bubien J, Jop R, Warnock D (1994) G-proteins modulate amiloride-sensitive sodium channels. J Biol Chem 269:17780-17783.
6. Chalfie M, Wolinsky E (1990) The identification and suppression of inherited neurodegeneration in C. elegans. Nature 345:410-416.
7. Chalfie M, Sulston JE, White JG, Southgate E, Thomson JN, Brenner S (1985) The neural circuit for touch sensitivity in C. elegans. J Neurosci 5:956-964.
8. Chalfie M, Tu Y, Euskirchen G, Ward W, Prasher D (1994) Green fluorescent protein as a marker for gene expression. Science 263:802-805.
9. Chen P, Nordstrom W, Gish B, Abrams J (1996) grim, a novel cell death gene in Drosophila. Genes Dev 10:1773-1782.
10. Choi D (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634.
11. Choi D (1996) Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6:667-672.
12. Coburn C, Bargmann C (1996) A putative cyclic nucleotide-gated channel is required for sensory development and function in C. elegans. Neuron 17:695-706.
13. Coffino P, Bourne H, Tomkins G (1975) Mechanism of lymphoma cell death induced by cyclic AMP. Am J Pathol 81:199-204.
14. Colwell C, Levine M (1995) Excitatory synaptic transmission in neostriatal neurons: regulation by cyclic AMP-dependent mechanisms. J Neurosci 15:1704-1713.
15. Curtis BM, Catterall WA (1985) Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase. Proc Natl Acad Sci USA 82:2528-2532.
16. Dent J, Davis M, Avery L (1997) avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans. EMBO J 16:5867-5879.
17. Devore J (1987) Probability and statistics for engineering and the sciences, 2nd Ed. Monterey,CA: Brooks/Cole.
18. DiAntonio A, Parfitt K, Schwarz T (1993) Synaptic transmission persists in synaptotagmin mutants of Drosophila. Cell 73:1281-1290.
19. D'Mello S, Galli C, Ciotti T, Calissano P (1993) Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci USA 90:10989-10993.
20. Dockwerth T, Johnson E (1993) Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J Cell Biol 123:1207-1222.
21. Driscoll M, Chalfie M (1991) The mec-4 gene is a member of a family of C. elegans genes that can mutate to induce neuronal degeneration. Nature 349:588-593.
22. Driscoll M, Kaplan J (1997) Mechanotransduction. In: C. elegans II (Riddle D, Blumenthal T, Meyer B, Priess J, eds), pp 645-677. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
23. Duprez E, Gjertsen B, Bernard O, Lanotte M, Doskeland S (1993) Antiapoptotic effect of heterozygously expressed mutant RI (A1a336→Asp) subunit of cAMP kinase I in a rat leukemia cell line. J Biol Chem 268:8332-8340.
24. Ellis H, Horvitz H (1986) Genetic control of programmed cell death in C. elegans. Cell 44:817-829.
25. Garcia-Anoveros J, Ma C, Chalfie M (1995) Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain. Curr Biol 5:441-448.
26. 2+ sensor for transmitter release at a central synapse. Cell 79:717-727.
27. Greengard P, Jen J, Nairn A, Stevens C (1991) Enhancement of glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science 253:1135-1138.
28. Grether M, Abrams J, Agapite J, White K, Steller H (1995) The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev 9:1694-1708.
29. Hall DH, Hedgecock EM (1991) Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Cell 65:837-847.
30. Hamelin M, Scott I, Culotti J (1992) The mec-7 β-tubulin gene of C. elegans is expressed primarily in the touch receptor neurons. EMBO J 11:2885-2893.
31. Hart A, Sims S, Kaplan J (1995) A synaptic code for sensory modalities revealed by analysis of the C. elegans GLR-1 glutamate receptor. Nature 378:82-85.
32. Hay B, Wassarman D, Rubin G (1995) Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell 83:1253-1262.
33. Hengartner M (1997) Cell death. In: C. elegans II (Riddle D, Blumenthal T, Meyer B, Priess J, eds), pp 383-415. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
34. Herrup K, Wilczynski S (1982) Cerebellar cell degeneration in the leaner mutant mouse. Neuroscience 7:2185-2196.
35. Huang L, Tzou P, Sternberg P (1994) The lin-15 locus encodes two negative regulators of C. elegans vulval development. Mol Biol Cell 5:395-412.
36. Huang M, Chalfie M (1994) Gene interactions affecting mechanosensory transduction in C. elegans. Nature 367:467-470.
37. Jackson P, Strange K (1993) Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux. Am J Physiol 265:C1489-C1500.
38. Kaplan JM, Horvitz HR (1993) A dual mechanosensory and chemosensory neuron in C. elegans. Proc Natl Acad Sci USA 90:2227-2231.
39. Kawakami A, Eguchi K, Matsuoka N, Tsuboi M, Kawabe Y, Ishikawa N, Ito K, Nagataki S (1996) Thyroid-stimulating hormone inhibits Fas antigen-mediated apoptosis of human thyrocytes in vitro. Endocrinology 137:3163-3169.
40. Khan A. Soloski M, Sharp A, Schilling G, Sabatini D, Li S, Ross C. Snyder S (1996) Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. Science 273:503-507.
41. Komatsu H, Mori I, Rhee J-S, Akaike N, Ohshima Y (1996) Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans. Neuron 17:707-718.
42. s protein induces neural degeneration. Genes Dev 11:1493-1503.
43. s and stimulate adenylyl cyclase in human pituitary tumors. Nature 340:692-696.
44. Lanotte M, Riviere J, Hermouet S, Houge G, Vintermyr O, Gjertsen B, Doskeland S (1991) Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate-kinase I in a myeloid leukemia cell line. J Cell Physiol 146:73-80.
45. 2+ channel cause myotonia in Caenorhabditis elegans. EMBO J 16:6066-6076.
46. 2+-activated neurotransmitter release. Cell 74:1125-1134.
47. Lyons L, Landis C, Harsh G, Vallar L, Grunewald K, Feichtinger H, Duh Q-Y, Clark O, Kawasaki E, Bourne H, McCormick F (1990) Two G-protein oncogenes in human endocrine tumors. Science 249:655-659.
48. Maricq AV, Peckol E, Driscoll M, Bargmann C (1995) glr-I, a C. elegans glutamate receptor that mediates mechanosensory signaling. Nature 378:78-81.
49. Michel P, Agid Y (1996) Chronic activation of the cyclic AMP signaling pathway promotes development and long-term survival of mesencephalic dopaminergic neurons. J Neurochem 67:1633-1642.
50. Mitani S, Du H, Hall D, Driscoll M, Chalfie M (1993) Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development 119:773-783.
51. Mullen R, Eicher E, Sidman R (1976) Purkinje cell degeneration, a new neurological mutation in the mouse. Proc Natl Acad Sci USA 73:208-212.
52. Nguyen M, Alfonso A, Johnson C, Rand J (1995) Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase. Genetics 140:527-535.
53. Nonet M, Grundahl K, Meyer B, Rand J (1993) Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin. Cell 73:1291-1305.
54. Norman D, Feng L, Cheng S, Gubbay J, Chan E, Heintz N (1995) The lurcher gene induces apoptotic death in cerebellar Purkinje cells. Development 121:1183-1193.
55. + channels in planar lipid bilayers. Am J Physiol 265:C85-C91.
56. Olney J (1986) Inciting excitotoxic cytocide among central neurons. Adv Exp Med Biol 203:631-645.
57. Otsuka A, Jeyaprakash A, Garcia-Anoveros J, Tang L, Fisk G, Hartshorne K, Franco R, Born T (1991) The C. elegans unc-104 gene encodes a putative kinesin heavy chain-like protein. Neuron 6:113-122.
58. Pulsinelli W, Brierley J, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11:491-498.
59. Raizen DM, Avery L (1994) Electrical activity in the pharynx of C. elegans. Neuron 12:483-495.
60. Rangnathanan R, Malicki D, Zuker C (1995) Signal transduction in Drosphila photoreceptors. Annu Rev Neurosci 18:283-317.
61. + channel protein following vasopressin treatment of A6 cells. J Biol Chem 263:13875-13879.
62. Savage C, Hamelin M, Culotti JG, Coulson A, Albertson DG, Chalfie M (1989) mec-7 is a beta-tubulin gene required for the production of 15-protofilament microtubules in C. elegans. Genes Dev 3:870-881.
63. Schafer W, Kenyon C (1995) A calcium-channel homologue required for adaptation to dopamine and serotonin in C. elegans. Nature 375:73-78.
64. o modulation of serotonin-controlled behaviors in C. elegans. Science 267:1648-1651.
65. Shreffler W, Margardino T, Shekdar K, Wolinsky E (1995) The unc-8 and sup-40 genes regulate ion channel function in C. elegans motor neurons. Genetics 139:1261-1272.
66. Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100:64-119.
67. Tavernarakis N, Shreffler W, Wang S, Driscoll M (1997) unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically gated channel that modulates C. elegans locomotion. Neuron 18:107-119.
68. Treinin M, Chalfie M (1995) A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans. Neuron 14:871-877.
69. Troemel E, Chou H, Dwyer N, Colbert H, Bargmann C (1995) Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans. Cell 83:207-218.
70. Wang L, Salter M, MacDonald J (1991) Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science 253:1132-1135.
71. White K, Tahaoglu E, Steller H (1996) Cell killing by the Drosophila gene reaper. Science 271:805-807.
72. i2 inhibit cyclic AMP accumulation. Nature 351:63-65.