ETA receptor blockade induces fibrosis of the clipped kidney in two-kidney-one-clip renovascular hypertensive rats

Journal of Hypertension

Volumn 18, Issue 12, 2000, Pages 1807-1814

  Hocher, Berthold ^a,b   George, Ines ^b   Diekmann, Fritz ^b   Zart, Rüdiger ^a,b   Rebstock, Johannes ^b   Schwarz, Anja ^a,b   Thöne Reineke, Christa ^b   Neumayer, Hans H ^a   Bauer, Christian ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

ETA receptor antagonist; Kidney fibrosis; Renal endothelin system; Renovascular hypertension

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ANTIHYPERTENSIVE THERAPY; ARTICLE; DRUG EFFECT; KIDNEY BLOOD FLOW; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENOVASCULAR HYPERTENSION;

EID: 0033664375     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200018120-00015     Document Type: Article

References (25)

1. Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia
2. Endothelin-A receptor antagonist prevents acute hypoxia-induced pulmonary hypertension in the rat
3. Effects of chronic ETA-receptor blockade in angiotensin II-induced hypertension
4. Angiotensin II increases tissue endothelin and induces vascular hypertrophy: Reversal by ET(A)-receptor antagonist
5. The paracrine endothelin system; pathophysiology and implications in clinical medicine
6. Regulation of the renal endothelin system in the two-kidney, one-clip renal hypertensive rat
7. A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression
8. Effects of renovascular hypertension on myocardial protein patterns - Analysis by computer-assisted 2-dimensional gel electrophoresis
9. Paracrine renal endothelin system in rats with liver cirrhosis
10. Distribution of endothelin receptor subtypes in the rat kidney; renal and haemodynamic effects of the mixed (A/B) endothelin receptor antagonist bosentan
11. Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis and renal cysts but not hypertension
12. Plasma angiotensin II: Dipsogenic levels and angiotensintensin-generating capacity of renin
13. Endothelin system-dependent cardiac remodeling in renovascular hypertension
14. Blocking both type A and B endothelin receptors in the kidney altenuates renal injury and prolongs survival in rats with remnant kidney
15. Effect of a specific endothelin receptor A antagonist on mRNA levels for extracellular matrix components and growth factors in diabetic glomeruli
16. Effect of a specific endothelin A receptor antagonist on murine lupus nephritis
17. Prevention of chronic renal allograft rejection in rats with an oral endothelin A receptor antagonist
18. The ET(A) receptor blocker LU 135252 prevents chronic transplant nephropathy in the 'Fisher to Lewis' model
19. Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth
20. Phenotypic transformation of normal rat kidney fibroblasts by endothelin-1. Different mode of action from lysophosphatidic acid, bradykinin, and prostaglandin f2alpha
21. Chronic ETA receptor blockade attenuates cardiac hypertrophy independently of blood pressure effects in renovascular hypertensive rats
22. Influence of the renal endothelin system on autoregulation of renal blood flow in spontaneously hypertensive rats
23. Effect of angiotensin converting enzyme inhibition in renovascular hypertension
24. Angiotensin-converting enzyme inhibition in renal disease; contrasting effects on renal function in renal artery stenosis and progressive renal injury
25. Pharmacologic nephrectomy with chronic angiotensin converting enzyme inhibitor treatment in renovascular hypertension in the rat