Interferon-γ signaling in human retinal pigment epithelial cells mediated by STAT1, ICSBP, and IRF-1 transcription factors

Investigative Ophthalmology and Visual Science

Volumn 40, Issue 5, 1999, Pages 976-982

  Li, Wenmei ^a   Nagineni, Chandrasekharam N ^a   Hooks, John J ^a   Chepelinsky, Ana B ^a   Egwuagu, Charles E ^a  

^a NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 2; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE SYNTHASE; STAT1 PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENE ACTIVATION; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

BLOTTING, WESTERN; CELL LINE; DNA; DNA PRIMERS; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INTERFERON REGULATORY FACTOR-1; INTERFERON REGULATORY FACTORS; INTERFERON-GAMMA, RECOMBINANT; PHOSPHOPROTEINS; PIGMENT EPITHELIUM OF EYE; PRECIPITIN TESTS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0033036602     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Wakefield D, Lloyd D. The role of cytokines in the pathogenesis of inflammatory eye disease. Cytokine. 1992;4:1-5.
2. Kijlstra A. Cytokines. Their role in uveal disease. Eye. 1997;11: 200-205.
3. Hooks JJ, Chan CC, Detrick B. Identification of the lymphokines, interferon-gamma and interleukin-2, in inflammatory eye diseases. Invest Ophthalmol Visual Sci. 1988;9:1444-1451.
4. Franks WA, Limb GA, Stanford MR, et al. Cytokines in human intraocular inflammation. Curr Eye Res. 1992;11:187-191.
5. Limb GA, Little BC, Meager A, et al. Cytokines in proliferative vitreoretinopathy. Eye. 1991;5:686-693.
6. Boehm U, Klamp T, Howard JC. Cellular responses to interferon-γ. Annu Rev Immunol. 1997;15:749-795.
7. Darnell JE Jr. STATs and gene regulation. Science. 1997;277:1630-1635.
8. Decker T, Kovarik P, Meinke A. GAS Elements: A few nucleotides with a major impact on cytokine-induced gene expression. J Interferon Cytokine Res. 1997;17:121-134.
9. Kordula T, Bugno M, Goldstein J, Travis J. Activation of signal transducer and activator of transcription-3 (STAT3) expression by interferon-γ and interleukin-6 in hepatoma cells. Biochem Biophys Res Commun. 1995;216:999-1005.
10. Nguyen H, Hiscott J, Pitha PM. The growing family of interferon regulatory factors. Cytokine Growth Factor Rev. 1997;8:293-312.
11. Russo JJ, Bohenzky RA, Chien M-C, et al. Nucleotide sequence of the kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci USA. 1996;93:14862-14867.
12. Detrick B, Newsome D, Percopo C, Hooks J. Class II antigen expression and gamma interferon modulation of monocytes and retinal pigment epithelial cells from patients with retinitis pigmentosa. Clin Immunol Immunopathol. 1985;36:201-211.
13. Detrick B, Rodrigues M, Chan C, Tso M, Hooks J. Expression of HLA-DR antigen on retinal pigment epithelial cells in retinitis pigmentosa. Am J Ophthalmol. 1986;101:584-590.
14. Baudouin C, Fredj-Reygrobellet D, Baudouin F, Lapalus P, Gastaud P. Immunohistologic study of proliferative vitreoretinopathy. Am J Ophthalmol. 1989;108:387-394.
15. Percopo C, Hooks JJ, Shinohara T, Detrick B. Cytokine mediated activation of a neuronal retinal resident cells provokes antigen presentation. J Immunol. 1990;145:4101-4107.
16. Zinn KM, Marmor MF. The Retinal Pigment Epithelium. Cambridge, MA: Harvard University Press; 1979.
17. Bok D. Retinal photoreceptor-pigment epithelium interactions. Invest Ophthalmol Vis Sci. 1985;26:1659-1694.
18. Tabbara KF. Disruption of the choroidoretinal interface by Toxoplasma. Eye. 1990;4:366-373.
19. Detrick B, Rhame J, Wang Y, Nagineni CN, Hooks JJ. Cytomegalovirus replication in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996;37:814-825.
20. Suzuki Y, Orellana MA, Schreiber RD, Remington JS. Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science. 1988;240:516-518.
21. Lucin P, Pavic I, Polic B, Jonjik S, Koszinowsky UH. Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands. J Virol. 1992;66:1977-1984.
22. Karupiah G, Xie Q-W, Buller ML, Nathan C, Duarte C, MacMicking JD. Inhibition of viral replication by interferon γ-induced nitric oxide synthase. Science. 1993:1445-1448.
23. Heise MT, Connick M, Virgin HW. Murine cytomegalovirus inhibits interferon-γ-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class-II-associated genes. J Exp Med. 1998;187:1037-1046.
24. Nagineni CN, Pardhasaradhi K, Martins MC, Detrick B, Hooks JJ. Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells. Infect Immun. 1996;64:4188-4196.
25. Nagineni CN, Kutty RK, Detrick B, Hooks J. Inflammatory cytokines induce intercellular adhesion molecule-1 (ICAM-1) mRNA synthesis and protein secretion by human retinal pigment epithelial cell cultures. Cytokine. 1996;8:622-630.
26. Hoey S, Grabowski PS, Ralston SH, Forrester JV, Liversidge J. Nitric oxide accelerate the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-γ-dependent mechanism. J Immunol. 1997:5132-5142.
27. Whitcup SM, Chan CC, Li Q, Nussenblatt RB. Expression of cell adhesion molecules in posterior uveitis. Arch Ophthalmol. 1992; 110:662-666.
28. Dunn KC, Aotaki-Keen AE, Putkey FR, Hjelmeland LM. ARPE-19, a human retinal pigment epithelial cell line with differentiated properties. Exp Eye Res. 1996;62:155-69.
29. Ponte P, Ng SY, Engel J, Gunning P, Kedes L. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA Nucleic Acids Res. 1984;12:1687-1696.
30. Tone S, Takikawa O, Habara-Ohkubo A, Kadoya A, Yoshida R, Kido R. Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA. Nucleic Acids Res. 1990;18:367.
31. Benech P, Mory Y, Revel M, Chebath J. Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase of human cells based on cDNAs and gene sequences EMBO J. 1985;4:2249-2256.
32. Maruyama M, Fujita T, Taniguchi T. Sequence of a cDNA coding for human IRF-1. Nucleic Acids Res. 1989;17:3292.
33. Itoh S, Harada H, Fujita T, Mimura T, Taniguchi T. Sequence of a cDNA coding for human IRF-2. Nucleic Acids Res. 1989;17:8372.
34. Weisz A, Marx P, Sharf R, et al. Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. J Biol Chem. 1992;267:25589-25596.
35. Schreiber EP, Matthias MM, Muller, Shaffner W. Rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells. Nucleic Acids Res. 1989;17:6419.
36. Kanno Y, Kozak CA, Schindler C, et al. The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3α subunit (or similar) moleculae binds. Mol Cell Biol. 1993;13:3951-3963.
37. Sato T, Selleri C, Young NS, Maciejewski JP. Inhibition of interferon regulatory factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of STAT1 and STAT3. Blood. 1997;90:4749-4758.
38. Boloventa C, Driggers PH, Marks MS, et al. Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Proc Natl Acad Sci USA. 1994;91:5045-5050.
39. Taniguchi T. Transcription factors IRF1 and IRF2: linking the immune responses and tumor suppression. J Cell Physiol. 1997; 173:128-130.
40. Egwuagu CE, Sztein J, Chan CC, et al. Ectopic expression of gamma interferon in the eyes of transgenic mice induces ocular pathology and MHC class II gene expression. Invest Ophthalmol Vis Sci. 1994;35:332-341.
41. Egwuagu CE, Sztein J, Chan CC, et al. γInterferon expression disrupts lens and retinal differentiation in transgenic mice. Dev Biol. 1994;166:557-568.
42. Driggers PH, Ennist DL, Gleason SL, et al. An interferon γ-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc Natl Acad Sci USA. 1990;87:3743-3747.
43. Holtschke E, Lohler J, Kanno Y, et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation in the ICSBP gene. Cell. 1996;87:307-317.
44. Nagineni CN, Detrick B, Hooks J. Synergistic effects of gamma interferon on inflammatory mediators that induce interleukin-6 gene expression and secretion by human retinal epithelial cells. Clin Diagn Lab Immunol. 1994;1:569-577.
45. Elner VM, Burnstine MA, Strieter RM, Kunkel SL, Elner SG. Cell-associated human retinal pigment epithelium interleukin-8 and monocyte chemotactic protein-1: immunochemical and in-situ hybridization analyses. Exp Eye Res. 1997;65:781-789.
46. Elner VM, Schaffner T, Taylor K, Glagov S. Immunophagocytic properties of retinal pigment epithelium cells. Science. 1981;211: 74-76.
47. Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H. Interferon gamma gene expression in sensory neurons: evidence for autocrine gene regulation. J Exp Med. 1997;186:2023-2031.
48. Thronton AM, Buller RML, Devico AL, Wang I-M, Ozato K. Inhibition of human immunodeficiency virus type 1 and vaccinia virus infection by a dominant negative factor of the interferon regulatory factor family expressed in monocytic cells. Proc Natl Acad Sci USA. 1996;3:383-387.