Preparation, characterization, and in vitro evaluation of 1- and 4-month controlled release orntide PLA and PLGA microspheres

Pharmaceutical Development and Technology

Volumn 5, Issue 4, 2000, Pages 585-596

  Kostanski, Janusz W ^a   Thanoo, B C ^b   DeLuca, Patrick P ^c  

^a BRISTOL MYERS SQUIBB   (United States)

^b Oakwood Laboratories LLC   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

LHRH antagonist; Orntide acetate; Peptide delivery; PLGA PLA microspheres; Sustained release

Indexed keywords

CARBOXYL GROUP; GONADORELIN ANTAGONIST; MICROSPHERE; ORNTIDE ACETATE; POLYGLACTIN; POLYLACTIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BIODEGRADATION; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DIALYSIS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION; TITRIMETRY;

GONADOTROPIN-RELEASING HORMONE; HYDROGEN-ION CONCENTRATION; LACTIC ACID; MICROSPHERES; POLYESTERS; POLYGLYCOLIC ACID; POLYMERS; TIME FACTORS;

EID: 0033661972     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-100102043     Document Type: Article

References (30)

1. Advances and opportunities in delivery of therapeutic proteins and peptides
2. Implantable drug delivery
3. Recombinant human bone morphogenetic protein-2 binding and incorporation in PLGA microsphere delivery systems
4. Optimization of the encapsulation and release of beta-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres
5. Intracranial delivery of recombinant nerve growth factor: Release kinetics and protein distribution for three delivery systems
6. Preparation and characterization of poly(D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysine) complexed plasmid DNA
7. PLGA microspheres containing plasmid DNA: Preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization
8. Encapsulation of plasmid DNA in biodegradable poly(D, L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery
9. Biodegradable microspheres in drug delivery
10. 2 from polylactic acid microcapsules, microparticles and modified microparticles
11. In vivo evaluation of biodegradable progesterone microspheres in mares
12. In vitro and in vivo evaluation of clarithromycin/poly(lactic acid) microspheres for intramuscular drug delivery
13. Evaluation of spray drying as a method for polylactide and polylactide-co-glycolide microsphere preparation
14. Spraydried polylactide microsphere preparation: Influence of the technological parameters
15. Bioerosion and biocompatibility of poly(d,l-lactic-co-glycolic acid) implants in brain
16. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres
17. Gonadotropin-releasing hormone agonists. Current uses for these increasingly important drugs
18. LH-RH Antagonists: State of the Art and Future Perspectives
19. Effect of the concurrent LHRH antagonist administration with a LHRH superagonist in rats
20. Characterization of biodegradable poly(D,L-lactide-co-glycolide) polymers and microspheres
21. Effect of processing parameters on the properties of peptide-containing PLGA microspheres
22. Effect of solvent removal technique on the matrix characteristics of polylactide/glycolide microspheres for peptide delivery
23. A novel in vitro release technique for peptide-containing biodegradable microspheres
24. Stability study of nanoparticles of poly(ε-caprolactone), poly(d,l-lactide) and poly (d,l-lactide-co-glycolide)
25. The biodegradability of polyester blends
26. Preparation of three-month depot injectable microspheres of Leuprorelin acetate using biodegradable polymers
27. Stability and release of bovine serum albumin encapsulated within poly(D,L-lactide-coglycolide) microparticles
28. Adsorption determines in-vitro release rate from biodegradable microspheres: Quantitative analysis of surface area during degradation
29. Importance of the test medium for the release kinetics of a somatostatin analogue from poly(D,L-lactide-co-glycolide) microspheres