Targeting the DNA cleavage activity of copper phenanthroline and Clip-Phen to A·T tracts via linkage to a poly-N-methylpyrrole

Bioconjugate Chemistry

Volumn 11, Issue 6, 2000, Pages 892-900

  Pitie, M ^a   Van Horn, J D ^b   Brion, D ^b   Burrows, C J ^b   Meunier, B ^a  

^a CNRS   (France)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REACTION; COPPER CHLORIDE; DNA CLEAVAGE; DNA FRAGMENT; PHENANTHROLINE; POLY N METHYLPYRROLE;

COPPER; COPPER COMPOUNDS;

AMINO-ACIDS; CARBOXYLIC DERIVATIVES; CLEAVAGE ACTIVITIES; COPPER PHENANTHROLINE; DNA CLEAVAGE; N-METHYLPYRROLE; N-METHYLPYRROLES; PHENANTHROLINES; POLY(N-METHYLPYRROLE); SOLID SUPPORTS;

DNA;

EID: 0033661333     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc000050t     Document Type: Article

References (29)

1. Chemical nucleases
2. Design of sequence-specific DNA-binding molecules
3. The oxidation-reduction potentials of some copper complexes
4. Cleavage of deoxyribonucleic acid by the 1,10-phenanthroline-cuprous complex. Hydrogen peroxide requirement and primary and secondary structure specificity
5. Noncovalent DNA binding of bis(1,10-phenanthroline)copper(I) and related compounds
6. The influence of reducing agent and 1,10-phenanthroline concentration on DNA cleavage by phenanthroline + copper
7. Nuclease activity of 1,10-phenanthroline-copper ion: Reaction with CGCGAATTCGCG and its complexes with netropsin and EcoRI
8. Nuclease activity of 1,10-phenanthroline-copper ion. Chemistry of deoxyribose oxidation
9. Scission of DNA with bis(1,10-phenanthroline)copper without intramolecular hydrogen migration
10. Targeted chemical nucleases
11. Optimizing the targeted chemical nuclease activity of 1,10-phenthroline-copper by ligand modification
12. Sequence targeted cleavage of single-stranded DNA by oligothymidilates covalently linked to 1,10-phenanthroline
13. Nuclease activity of 1,10-phenanthroline-copper: New conjugates with low molecular weight targeting ligands
14. Transforming the Escherichia coli Trp repressor into site-specific nuclease
15. High-specificity DNA cleavage agent: Design and application to kilobase and megabase DNA substrates
16. Structure of the Escherichia coli Fis-DNA complex probed by protein conjugated with 1,10-phenanthroline copper(I) complex
17. Preparation of the new bis(phenanthroline)ligand 'Clip-Phen' and evaluation of the nuclease activity of the corresponding copper complex
18. 3 position of the phenanthroline units
19. Preparation of a spermine conjugate of the bis-phenanthroline ligand 'Clip-Phen' and evaluation of the corresponding copper complex
20. Synthesis of two acridine conjugates of the bis(phenanthroline) ligand 'Clip-Phen' and evaluation of the nuclease activity of the corresponding copper complexes
21. Sequence specific DNA minor groove binders. Design and synthesis of netropsin and distamycin analogues
22. Solid-phase synthesis of polyamides containing imidazole and pyrrole amino acids
23. Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands
24. Sequencing end-labeled DNA with base specific chemical cleavages
25. Carbon-hydrogen bonds of DNA sugar units as targets for chemical nucleases and drugs
26. Oxidative nucleobase modifications leading to strand scission
27. Design and synthesis of a sequence-specific DNA cleaving molecule. (Distamycin-EDTA)iron (II)