The promoter of the long variant of collagen XVIII, the precursor of endostatin, contains liver-specific regulatory elements

Hepatology

Volumn 32, Issue 6, 2000, Pages 1377-1385

  Liétard, Jocelyne ^a,b   Théret, Nathalie ^a   Rehn, Marko ^b   Musso, Orlando ^a   Dargère, Delphine ^a   Pihlajaniemi, Taina ^b   Clément, Bruno ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITY OF OULU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGEN TYPE 18; ENDOSTATIN; GENE PRODUCT; LUCIFERASE; NUCLEAR FACTOR; PROTEIN COL18A1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL STRAIN HEPG2; GENE EXPRESSION; GENE LOCATION; GENE LOCUS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SEQUENCE ANALYSIS; SILENCER GENE;

EID: 0033659330     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2000.20066     Document Type: Article

References (52)

1. Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
2. How tumors become angiogenic
3. Angiogenesis in cancer, vascular, rheumatoid and other disease
4. Homeostatic control of angiogenesis: A newly identified function of the liver?
5. Antiangiogenic activity of the cleaved conformation of the serpin antithrombin
6. Prothrombin kringle-2 domain has a growth inhibitory activity against basic fibroblast growth factor-stimulated capillary endothelial cells
7. Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis
8. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
9. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
10. Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin
11. The generation of endostatin is mediated by elastase
12. Secreted cathepsin L generates endostatin from collagen XVIII
13. The short and long forms of type XVIII collagen show clear tissue specificities in their expression and location in basement membrane zones in humans
14. Collagen XVIII is localized in sinusoids and basement membrane zones and expressed by hepatocytes and activated stellate cells in fibrotic human liver
15. The short and long forms of type XVIII collagen show clear tissue specificities in their expression and location in basement membrane zones in humans
16. Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the α1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21
17. Characterization of the mouse gene for the α1 chain of type XVIII collagen (Col18α1) reveals that the three variant N-terminal polypeptide forms are transcribed from two widely separated promoters
18. Mouse Col18α1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones
19. Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts
20. Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts
21. Luciferase reporter gene vectors for analysis of promoters and enhancers
22. Influence of the content in transcription factors on the phenotype of mouse hepatocyte-like cell lines
23. Overproduction of a truncated hepatocyte nuclear factor 3 protein inhibits expression of liver-specific genes in hepatoma cells
24. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
25. A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells
26. Sites-directed mutagenesis of albumin transcriptional enhancer with the polymerase chain reaction
27. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α1-antitrypsin genes
28. Single-step method of RNA isolation by guanidinium-thiocyanate-phenol chloroform extraction
29. SP1-mediated transactivation of LAMC1 promoter and coordinated expression of laminin γ1 and SP1 in human hepatocellular carcinomas
30. The nudeotide sequence of a rat ribosomal ribonucleic acid gene and a proposal for the secondary structure of 18S ribosomal ribonucleic acid
31. c-Krox binds to several sites in the promoter of both mouse type 1 collagen genes. Structure/function study and developmental expression analysis
32. Modulation of liver-specific transcription by interactions between Hepatocyte Nuclear Factor 3 and Nuclear Factor 1 binding DNA in close apposition
33. Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter
34. Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene
35. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter
36. Characterization of a GC-rich region containing Sp1 binding site(s) as a constitutive responsive element of the α2(I) collagen gene in human fibrobasts
37. Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription
38. Directional regulatory activity of cis-acting elements in the bidirectional α1(IV) and α2(IV) collagen gene promoter
39. Expression of laminin γ1 in cultured hepatocytes involves repeated CTC and GC elements in the LAMC1 promoter
40. c-Krox, a transcriptional regulator of type 1 collagen gene expression, is preferentially expressed in skin
41. Liver-enriched transcription factors and hepatocyte differentiation
42. The hepatocyte nuclear factor-3/forkhead transcription regulatory family in development, inflammation, and neoplasia
43. Expression of hepatic transcription factors during liver development and oval cell differentiation
44. HNF3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally
45. Hepatocyte nuclear factor 3α belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head
46. Hepatocyte nuclear factor 3/fork head or 'winged helix' proteins: A family of transcription factors of diverse biologic function
47. Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro
48. The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3β involves a cell-specific factor and positive autoactivation
49. Complex organization of CTF/NF1, C/EBP, and HNF3 binding sites within the promoter of the liver-specific vitellogenin gene
50. A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication
51. Nuclear factor 1 acts as a transcription factor on the MMTV promoter but competes with steroid hormone receptors for DNA binding
52. Identification of a potent adipocyte-specific enhancer: Involvement of an NF-1-like factor