Clinical and mechanistic differences between FK506 (tacrolimus) and cyclosporin A

Nephrology Dialysis Transplantation

Volumn 15, Issue 12, 2000, Pages 1916-1918

  Almawi, Wassim Y ^a,b   Melemedjian, Ohannes K ^a  

^a HAIGAZIAN UNIVERSITY   (Lebanon)

^b ARABIAN GULF UNIVERSITY   (Bahrain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CD4 ANTIGEN; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; INTERLEUKIN 5; INTERLEUKIN 7; NUCLEAR FACTOR; RAPAMYCIN; STEROID; TACROLIMUS;

CONTROLLED STUDY; DRUG MECHANISM; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; NOTE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0033652414     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/15.12.1916     Document Type: Note

References (20)

1. Identification of calcineurin as a key signalling enzyme in T lymphocyte activation
2. Cyclosporin A. FK506, and rapamycin: More than just immunosuppression
3. An alternate mechanism of glucocorticoid anti-proliferative effect: Promotion of a Th2 cytokine-secreting profile
4. 2+ release
5. Molecular mechanisms of new immunosuppressants
6. Distinct tissue and cellular distribution of two major isoforms of calcineurin
7. The mechanism of action of cyclosporin A and FK506
8. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin
9. Inhibition of cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context
10. Cyclosporin A and tacrolimus (FK506) suppress expression of inducible nitric oxide synthase in vitro by different mechanisms
11. Differences between cyclosporin A and tacrolimus in organ transplantation
12. Efficacy of tacrolimus in the treatment of refractory rejection in heart and lung transplant recipients
13. The effect of cyclosporin A. FK506, and rapamycin on the murine contact sensitivity reaction
14. IL-2-induced I1-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506
15. Differences in type 1 and type 2 intracytoplasmic cytokines, detected by flow cytometry, according to immunosuppression (cyclosporin A vs. tacrolimus) in stable renal allograft recipients
16. Which calcineurin inhibitor is preferred in renal transplantation: Tacrolimus or cyclosporine?
17. Comparison of the effects of FK506, cyclosporin A and rapamycin on IL-2 production
18. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin
19. Tacrolimus therapy for refractory renal allograft rejection: Experience with steroid withdrawal
20. Tacrolimus (FK506) is superior to cyclosporin A in liver transplantation