-
1
-
-
1642532045
-
Mycophenolate mofetil (RS-61443): Mode of action and effects on graft rejection
-
THOMPSON AW. STARZL TF, eds. New York: Edward Arnold
-
ALLISON AC, EUGUI EM. Mycophenolate mofetil (RS-61443): mode of action and effects on graft rejection. In: THOMPSON AW. STARZL TF, eds. Immunosuppressive Drugs, Developments in Anti-Rejection Therapy. New York: Edward Arnold, 1994: 141.
-
(1994)
Immunosuppressive Drugs, Developments in Anti-Rejection Therapy
, pp. 141
-
-
Allison, A.C.1
Eugui, E.M.2
-
2
-
-
0025981270
-
RS-61443 - A new. potent immunosuppressive agent
-
PLATZ KP, SOLLINGER HW, HULLET DA. ECKHOEF DE. EUGUI EM, ALLISON AC. RS-61443 - A new. potent immunosuppressive agent. Transplantation 1991: 51: 27.
-
(1991)
Transplantation
, vol.51
, pp. 27
-
-
Platz, K.P.1
Sollinger, H.W.2
Hullet, D.A.3
Eckhoef, D.E.4
Eugui, E.M.5
Allison, A.C.6
-
3
-
-
0020663603
-
Characterization of mutant murine lymphoma cells with altered inosinate dehydrogenase activities
-
ULLMAN B. Characterization of mutant murine lymphoma cells with altered inosinate dehydrogenase activities. J Biol Chem 1983: 258: 523.
-
(1983)
J Biol Chem
, vol.258
, pp. 523
-
-
Ullman, B.1
-
4
-
-
0021084824
-
Purine metabolism in myeloid precursor cells during maturation
-
LUCAS DL, WEBSTER HK, WRIGHT DG. Purine metabolism in myeloid precursor cells during maturation. J Clin Invest 1983: 72: 1889.
-
(1983)
J Clin Invest
, vol.72
, pp. 1889
-
-
Lucas, D.L.1
Webster, H.K.2
Wright, D.G.3
-
5
-
-
0022575008
-
Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5́-phosphate dehydrogenase
-
SOKOLOSKI JA, BLAIR OC, SARTORELLI AC. Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5́-phosphate dehydrogenase Cancer Res 1986: 46: 2314.
-
(1986)
Cancer Res
, vol.46
, pp. 2314
-
-
Sokoloski, J.A.1
Blair, O.C.2
Sartorelli, A.C.3
-
6
-
-
0016758998
-
Immunological observations on patients with Lesch-Nyhan syndrome, and on the role of de-novo purine synthesis in lymphocyte transformation
-
ALLISON AC, HOVI T, WATTS RWE, WEBSTER ADB. Immunological observations on patients with Lesch-Nyhan syndrome, and on the role of de-novo purine synthesis in lymphocyte transformation. Lancet 1975: 2: 1179.
-
(1975)
Lancet
, vol.2
, pp. 1179
-
-
Allison, A.C.1
Hovi, T.2
Watts, R.W.E.3
Webster, A.D.B.4
-
7
-
-
0027732959
-
New small molecule immunosuppressants for transplantation: Review of essential concepts
-
MORRIS RE. New small molecule immunosuppressants for transplantation: review of essential concepts. J Heart Lung Transplant 1993: 12: S275.
-
(1993)
J Heart Lung Transplant
, vol.12
-
-
Morris, R.E.1
-
8
-
-
0027252642
-
Inhibitors of de novo purine and pyrimidine synthesis as immunosuppressive drugs
-
ALLISON AC, EUGUI EM. Inhibitors of de novo purine and pyrimidine synthesis as immunosuppressive drugs. Transplant Proc 1993: 25 (suppl 2): 8.
-
(1993)
Transplant Proc
, vol.25
, Issue.2 SUPPL.
, pp. 8
-
-
Allison, A.C.1
Eugui, E.M.2
-
9
-
-
0027094084
-
Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism
-
DAYTON JS, TURKA LA, THOMPSON CB, MITCHELL BS. Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism. Mol Pharmacol 1992: 41: 671.
-
(1992)
Mol Pharmacol
, vol.41
, pp. 671
-
-
Dayton, J.S.1
Turka, L.A.2
Thompson, C.B.3
Mitchell, B.S.4
-
10
-
-
0025821616
-
Guanine ribonucleotide depletion inhibits T cell activation
-
TURKA LA, DAYTON J, SINCLAIR G, THOMPSON CB, MITCHELL BS. Guanine ribonucleotide depletion inhibits T cell activation. J Clin Invest 1991: 87: 940.
-
(1991)
J Clin Invest
, vol.87
, pp. 940
-
-
Turka, L.A.1
Dayton, J.2
Sinclair, G.3
Thompson, C.B.4
Mitchell, B.S.5
-
13
-
-
0025917840
-
Cyclosporine, FK506, and other drugs in organ transplantation
-
MORRIS PJ. Cyclosporine, FK506, and other drugs in organ transplantation. Curr Opin Immunol 1991: 3: 748.
-
(1991)
Curr Opin Immunol
, vol.3
, pp. 748
-
-
Morris, P.J.1
-
14
-
-
0027189955
-
The design and development of an immunosuppressive drug, mycophenolate mofetil
-
ALLISON AC, EUGUI EM. The design and development of an immunosuppressive drug, mycophenolate mofetil. Springer Semin Immunopathol 1993: 14. 353.
-
(1993)
Springer Semin Immunopathol
, vol.14
, pp. 353
-
-
Allison, A.C.1
Eugui, E.M.2
-
15
-
-
0014546166
-
The inhibition of nucleic acid synthesis by mycophenolic acid
-
FRANKLIN TJ, COOK JM. The inhibition of nucleic acid synthesis by mycophenolic acid. Biochem J 1969: 113: 515.
-
(1969)
Biochem J
, vol.113
, pp. 515
-
-
Franklin, T.J.1
Cook, J.M.2
-
16
-
-
8044262133
-
Aspects of allograft rejection, IV: Evaluation of new pharmacologic agents for prevention of allograft rejection
-
HALLORAN PF. Aspects of allograft rejection, IV: evaluation of new pharmacologic agents for prevention of allograft rejection. Transplant Rev 1995: 9: 138.
-
(1995)
Transplant Rev
, vol.9
, pp. 138
-
-
Halloran, P.F.1
-
17
-
-
0025984070
-
Immunosuppressive and long-acting anti-inflammatory activity of mycophenolic acid and derivative, RS-61443
-
ALLISON AC, EUGUI EM. Immunosuppressive and long-acting anti-inflammatory activity of mycophenolic acid and derivative, RS-61443. Br J Rheum 1991: 30 (suppl 2): 57.
-
(1991)
Br J Rheum
, vol.30
, Issue.2 SUPPL.
, pp. 57
-
-
Allison, A.C.1
Eugui, E.M.2
-
18
-
-
0027786828
-
New immunosuppressive drugs: Mechanistic insights and potential therapeutic advances
-
THOMSON AW. STARZL TE. New immunosuppressive drugs: mechanistic insights and potential therapeutic advances. Immunol Rev 1993: 136: 71.
-
(1993)
Immunol Rev
, vol.136
, pp. 71
-
-
Thomson, A.W.1
Starzl, T.E.2
-
19
-
-
0027514153
-
One-year follow-up results of a phase I trial of mycophenolate mofetil (RS61443) in cadaveric renal transplantation
-
DEIERHOI MH, SOLLINGER HW, DIETHELM AG, BELZER FO, KAUFFMAN RS. One-year follow-up results of a phase I trial of mycophenolate mofetil (RS61443) in cadaveric renal transplantation. Transplant Proc 1993: 25: 693.
-
(1993)
Transplant Proc
, vol.25
, pp. 693
-
-
Deierhoi, M.H.1
Sollinger, H.W.2
Diethelm, A.G.3
Belzer, F.O.4
Kauffman, R.S.5
-
20
-
-
0024976004
-
Cyclosporine
-
KAHAN BD. Cyclosporine. N Engl J Med 1989: 321: 1725.
-
(1989)
N Engl J Med
, vol.321
, pp. 1725
-
-
Kahan, B.D.1
-
21
-
-
0023720436
-
Regulation of gene expression m lectin-stimulated or lymphocyte-stimulated T lymphocytes
-
REED JC, PRYSTOWSKY MB, NOWELL PC. Regulation of gene expression m lectin-stimulated or lymphocyte-stimulated T lymphocytes. Transplantation 1988: 46: 85S.
-
(1988)
Transplantation
, vol.46
-
-
Reed, J.C.1
Prystowsky, M.B.2
Nowell, P.C.3
-
23
-
-
0029028666
-
Calcineurin activity is only partially inhibited in leukocytes of cyclosporine treated patients
-
BATIUK TD, PAZDERKA J, HALLORAN PE Calcineurin activity is only partially inhibited in leukocytes of cyclosporine treated patients. Transplantation 1995: 59: 1400.
-
(1995)
Transplantation
, vol.59
, pp. 1400
-
-
Batiuk, T.D.1
Pazderka, J.2
Halloran, P.E.3
-
25
-
-
13344258876
-
The cytosolic-binding protein for the immunosuppressant FK506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans-isomerase
-
SIEKERA JJ, WIEDERECHT G, GRENLICH G, et al. The cytosolic-binding protein for the immunosuppressant FK506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans-isomerase. J Biol Chem 1990: 265: 2101.
-
(1990)
J Biol Chem
, vol.265
, pp. 2101
-
-
Siekera, J.J.1
Wiederecht, G.2
Grenlich, G.3
-
26
-
-
0029133116
-
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
-
GRIFFITH JP, KIM JL, KIM EE. SINTCHAK MD, THOMSON JA. FITZGIBBON MJ, FLEMING MA, CARON PR, HSIAO K, NAVIA MAI: X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell 1995: 82: 507.
-
(1995)
Cell
, vol.82
, pp. 507
-
-
Griffith, J.P.1
Kim, J.L.2
Kim, E.E.3
Sintchak, M.D.4
Thomson, J.A.5
Fitzgibbon, M.J.6
Fleming, M.A.7
Caron, P.R.8
Hsiao, K.9
Navia, M.A.I.10
-
28
-
-
0025893168
-
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
-
LIU J, FARMER JD JR, LANE WS, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991: 66: 807.
-
(1991)
Cell
, vol.66
, pp. 807
-
-
Liu, J.1
Farmer Jr., J.D.2
Lane, W.S.3
-
29
-
-
0008755365
-
Advances in therapeutic immunosuppression: Biology, molecular actions, and clinical implications
-
BIERER BE. Advances in therapeutic immunosuppression: biology, molecular actions, and clinical implications. Curr Opin Hematol 1993: 149.
-
(1993)
Curr Opin Hematol
, pp. 149
-
-
Bierer, B.E.1
-
30
-
-
0026780166
-
The spectrum of action of new immunosuppressive drugs
-
THOMSON AW. The spectrum of action of new immunosuppressive drugs. Clin Exp Immunol 1992: 89: 170.
-
(1992)
Clin Exp Immunol
, vol.89
, pp. 170
-
-
Thomson, A.W.1
-
31
-
-
13344278963
-
-
In press
-
Nature (London) 1995: In press.
-
(1995)
Nature (London)
-
-
-
32
-
-
0026659046
-
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kD S6 protein kinases
-
CHUNG J, KUO CJ, CRABTREE GR, et al. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kD S6 protein kinases. Cell 1992: 69: 1227.
-
(1992)
Cell
, vol.69
, pp. 1227
-
-
Chung, J.1
Kuo, C.J.2
Crabtree, G.R.3
-
33
-
-
0026721092
-
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
-
Kuo CJ, CHUNG J, FIORENTINO DF et al. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature (London) 1992: 358: 70.
-
(1992)
Nature (London)
, vol.358
, pp. 70
-
-
Kuo, C.J.1
Chung, J.2
Fiorentino, D.F.3
-
34
-
-
0028210361
-
Relationship between multiple biologic effects of rapamycin and the inhibition of p70S6 protein kinase activity
-
DUMONT FJ, ALTMEYER A, KASTNER C, et al. Relationship between multiple biologic effects of rapamycin and the inhibition of p70S6 protein kinase activity. J Immunol 1994: 152: 992.
-
(1994)
J Immunol
, vol.152
, pp. 992
-
-
Dumont, F.J.1
Altmeyer, A.2
Kastner, C.3
-
35
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
SABATINI DM. ERDJUMENT-BROMAGE H, LUI M, et al. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994: 78: 35.
-
(1994)
Cell
, vol.78
, pp. 35
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
-
36
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
BROWNE EJ, ALBERS MW, SHIN TB, et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature (London) 1994: 369: 756.
-
(1994)
Nature (London)
, vol.369
, pp. 756
-
-
Browne, E.J.1
Albers, M.W.2
Shin, T.B.3
-
37
-
-
0029071264
-
TOR kinase domains are required for two distinct functions. only one of which is inhibited by rapamycin
-
ZHENG XF, et al. TOR kinase domains are required for two distinct functions. only one of which is inhibited by rapamycin. Cell 1995: 82: 121.
-
(1995)
Cell
, vol.82
, pp. 121
-
-
Zheng, X.F.1
-
38
-
-
0025990313
-
New horizons in immunosuppression
-
SIMMONS RL, WANG SC New horizons in immunosuppression. Transplant Proc 1991: 23: 2152.
-
(1991)
Transplant Proc
, vol.23
, pp. 2152
-
-
Simmons, R.L.1
Wang, S.C.2
-
39
-
-
0027309093
-
Renal transplantation: Is the impact of new molecules acting on the immune system already clinically measurable?
-
MUNN SR. Renal transplantation: is the impact of new molecules acting on the immune system already clinically measurable? J Nephrol 1994: 6: 6.
-
(1994)
J Nephrol
, vol.6
, pp. 6
-
-
Munn, S.R.1
-
40
-
-
0027184873
-
Mechanism of action of 15 eoxyspergualin, a novel immunosuppressive drug
-
TEPPER MA, NADLER SG, MAZZUCCO C, et al. Mechanism of action of 15 eoxyspergualin, a novel immunosuppressive drug. Ann NY Acad Sci 685: 136.
-
Ann NY Acad Sci
, vol.685
, pp. 136
-
-
Tepper, M.A.1
Nadler, S.G.2
Mazzucco, C.3
-
41
-
-
0026526303
-
Interaction of the immunosuppressant deoxyspergualin with a member of the hsp70 family of heat shock proteins
-
NADLER SG, TEPPER MA, SCHACTER B, MAZZUCCO CE. Interaction of the immunosuppressant deoxyspergualin with a member of the hsp70 family of heat shock proteins. Science 258: 484.
-
Science
, vol.258
, pp. 484
-
-
Nadler, S.G.1
Tepper, M.A.2
Schacter, B.3
Mazzucco, C.E.4
-
42
-
-
0026567911
-
A case for chaperones in antigen processing
-
DE NAGEL DC, PIERCE SK. A case for chaperones in antigen processing. Immunol Today 1992: 13: 86.
-
(1992)
Immunol Today
, vol.13
, pp. 86
-
-
De Nagel, D.C.1
Pierce, S.K.2
-
43
-
-
0028029788
-
The immunosuppressant deoxyspergualin (DSG) inhibits antigen processing in monocytes
-
HOEGER PH. TEPPER MA, FAITH A. et al. The immunosuppressant deoxyspergualin (DSG) inhibits antigen processing in monocytes. J Immunol 1994: 153: 3908.
-
(1994)
J Immunol
, vol.153
, pp. 3908
-
-
Hoeger, P.H.1
Tepper, M.A.2
Faith, A.3
-
44
-
-
0028867899
-
Immunosuppression by glucocorticoids: Inhibition of NK-κB activity through induction of IκB synthesis
-
AUPHAN N. DI DONATO JA, ROSETTE C, HELMBERG A, KARIN M. Immunosuppression by glucocorticoids: inhibition of NK-κB activity through induction of IκB synthesis. Science 1995: 270: 286.
-
(1995)
Science
, vol.270
, pp. 286
-
-
Auphan, N.1
Di Donato, J.A.2
Rosette, C.3
Helmberg, A.4
Karin, M.5
-
45
-
-
0028879819
-
Role of transcriptional activation of TκBα in mediation of immunosuppression by glucocorticoids
-
SCHEINMAN RI. COGSWELL PC. LOFQUIST AK, BALDWIN AS Jr. Role of transcriptional activation of TκBα in mediation of immunosuppression by glucocorticoids. Science 1995: 270: 283.
-
(1995)
Science
, vol.270
, pp. 283
-
-
Scheinman, R.I.1
Cogswell, P.C.2
Lofquist, A.K.3
Baldwin Jr., A.S.4
|