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Volumn 10, Issue 1 II, 1996, Pages 118-123

Molecular mechanisms of new immunosuppressants

Author keywords

Cyclosporine; Deoxyspergualin; Mizoribine; Mycophenolate mofetil; Mycophenolic acid; Rapamycin; Tacrolimus

Indexed keywords

15 DEOXYSPERGUALIN; BREQUINAR; CALCINEURIN; CYCLOPHILIN; CYCLOSPORIN; GUANINE NUCLEOTIDE; IMMUNOSUPPRESSIVE AGENT; INOSINATE DEHYDROGENASE; LEFLUNOMIDE; MIZORIBINE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

EID: 0029870723     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (109)

References (45)
  • 1
    • 1642532045 scopus 로고
    • Mycophenolate mofetil (RS-61443): Mode of action and effects on graft rejection
    • THOMPSON AW. STARZL TF, eds. New York: Edward Arnold
    • ALLISON AC, EUGUI EM. Mycophenolate mofetil (RS-61443): mode of action and effects on graft rejection. In: THOMPSON AW. STARZL TF, eds. Immunosuppressive Drugs, Developments in Anti-Rejection Therapy. New York: Edward Arnold, 1994: 141.
    • (1994) Immunosuppressive Drugs, Developments in Anti-Rejection Therapy , pp. 141
    • Allison, A.C.1    Eugui, E.M.2
  • 3
    • 0020663603 scopus 로고
    • Characterization of mutant murine lymphoma cells with altered inosinate dehydrogenase activities
    • ULLMAN B. Characterization of mutant murine lymphoma cells with altered inosinate dehydrogenase activities. J Biol Chem 1983: 258: 523.
    • (1983) J Biol Chem , vol.258 , pp. 523
    • Ullman, B.1
  • 4
    • 0021084824 scopus 로고
    • Purine metabolism in myeloid precursor cells during maturation
    • LUCAS DL, WEBSTER HK, WRIGHT DG. Purine metabolism in myeloid precursor cells during maturation. J Clin Invest 1983: 72: 1889.
    • (1983) J Clin Invest , vol.72 , pp. 1889
    • Lucas, D.L.1    Webster, H.K.2    Wright, D.G.3
  • 5
    • 0022575008 scopus 로고
    • Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5́-phosphate dehydrogenase
    • SOKOLOSKI JA, BLAIR OC, SARTORELLI AC. Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5́-phosphate dehydrogenase Cancer Res 1986: 46: 2314.
    • (1986) Cancer Res , vol.46 , pp. 2314
    • Sokoloski, J.A.1    Blair, O.C.2    Sartorelli, A.C.3
  • 6
    • 0016758998 scopus 로고
    • Immunological observations on patients with Lesch-Nyhan syndrome, and on the role of de-novo purine synthesis in lymphocyte transformation
    • ALLISON AC, HOVI T, WATTS RWE, WEBSTER ADB. Immunological observations on patients with Lesch-Nyhan syndrome, and on the role of de-novo purine synthesis in lymphocyte transformation. Lancet 1975: 2: 1179.
    • (1975) Lancet , vol.2 , pp. 1179
    • Allison, A.C.1    Hovi, T.2    Watts, R.W.E.3    Webster, A.D.B.4
  • 7
    • 0027732959 scopus 로고
    • New small molecule immunosuppressants for transplantation: Review of essential concepts
    • MORRIS RE. New small molecule immunosuppressants for transplantation: review of essential concepts. J Heart Lung Transplant 1993: 12: S275.
    • (1993) J Heart Lung Transplant , vol.12
    • Morris, R.E.1
  • 8
    • 0027252642 scopus 로고
    • Inhibitors of de novo purine and pyrimidine synthesis as immunosuppressive drugs
    • ALLISON AC, EUGUI EM. Inhibitors of de novo purine and pyrimidine synthesis as immunosuppressive drugs. Transplant Proc 1993: 25 (suppl 2): 8.
    • (1993) Transplant Proc , vol.25 , Issue.2 SUPPL. , pp. 8
    • Allison, A.C.1    Eugui, E.M.2
  • 9
    • 0027094084 scopus 로고
    • Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism
    • DAYTON JS, TURKA LA, THOMPSON CB, MITCHELL BS. Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism. Mol Pharmacol 1992: 41: 671.
    • (1992) Mol Pharmacol , vol.41 , pp. 671
    • Dayton, J.S.1    Turka, L.A.2    Thompson, C.B.3    Mitchell, B.S.4
  • 12
  • 13
    • 0025917840 scopus 로고
    • Cyclosporine, FK506, and other drugs in organ transplantation
    • MORRIS PJ. Cyclosporine, FK506, and other drugs in organ transplantation. Curr Opin Immunol 1991: 3: 748.
    • (1991) Curr Opin Immunol , vol.3 , pp. 748
    • Morris, P.J.1
  • 14
    • 0027189955 scopus 로고
    • The design and development of an immunosuppressive drug, mycophenolate mofetil
    • ALLISON AC, EUGUI EM. The design and development of an immunosuppressive drug, mycophenolate mofetil. Springer Semin Immunopathol 1993: 14. 353.
    • (1993) Springer Semin Immunopathol , vol.14 , pp. 353
    • Allison, A.C.1    Eugui, E.M.2
  • 15
    • 0014546166 scopus 로고
    • The inhibition of nucleic acid synthesis by mycophenolic acid
    • FRANKLIN TJ, COOK JM. The inhibition of nucleic acid synthesis by mycophenolic acid. Biochem J 1969: 113: 515.
    • (1969) Biochem J , vol.113 , pp. 515
    • Franklin, T.J.1    Cook, J.M.2
  • 16
    • 8044262133 scopus 로고
    • Aspects of allograft rejection, IV: Evaluation of new pharmacologic agents for prevention of allograft rejection
    • HALLORAN PF. Aspects of allograft rejection, IV: evaluation of new pharmacologic agents for prevention of allograft rejection. Transplant Rev 1995: 9: 138.
    • (1995) Transplant Rev , vol.9 , pp. 138
    • Halloran, P.F.1
  • 17
    • 0025984070 scopus 로고
    • Immunosuppressive and long-acting anti-inflammatory activity of mycophenolic acid and derivative, RS-61443
    • ALLISON AC, EUGUI EM. Immunosuppressive and long-acting anti-inflammatory activity of mycophenolic acid and derivative, RS-61443. Br J Rheum 1991: 30 (suppl 2): 57.
    • (1991) Br J Rheum , vol.30 , Issue.2 SUPPL. , pp. 57
    • Allison, A.C.1    Eugui, E.M.2
  • 18
    • 0027786828 scopus 로고
    • New immunosuppressive drugs: Mechanistic insights and potential therapeutic advances
    • THOMSON AW. STARZL TE. New immunosuppressive drugs: mechanistic insights and potential therapeutic advances. Immunol Rev 1993: 136: 71.
    • (1993) Immunol Rev , vol.136 , pp. 71
    • Thomson, A.W.1    Starzl, T.E.2
  • 19
    • 0027514153 scopus 로고
    • One-year follow-up results of a phase I trial of mycophenolate mofetil (RS61443) in cadaveric renal transplantation
    • DEIERHOI MH, SOLLINGER HW, DIETHELM AG, BELZER FO, KAUFFMAN RS. One-year follow-up results of a phase I trial of mycophenolate mofetil (RS61443) in cadaveric renal transplantation. Transplant Proc 1993: 25: 693.
    • (1993) Transplant Proc , vol.25 , pp. 693
    • Deierhoi, M.H.1    Sollinger, H.W.2    Diethelm, A.G.3    Belzer, F.O.4    Kauffman, R.S.5
  • 20
    • 0024976004 scopus 로고
    • Cyclosporine
    • KAHAN BD. Cyclosporine. N Engl J Med 1989: 321: 1725.
    • (1989) N Engl J Med , vol.321 , pp. 1725
    • Kahan, B.D.1
  • 21
    • 0023720436 scopus 로고
    • Regulation of gene expression m lectin-stimulated or lymphocyte-stimulated T lymphocytes
    • REED JC, PRYSTOWSKY MB, NOWELL PC. Regulation of gene expression m lectin-stimulated or lymphocyte-stimulated T lymphocytes. Transplantation 1988: 46: 85S.
    • (1988) Transplantation , vol.46
    • Reed, J.C.1    Prystowsky, M.B.2    Nowell, P.C.3
  • 23
    • 0029028666 scopus 로고
    • Calcineurin activity is only partially inhibited in leukocytes of cyclosporine treated patients
    • BATIUK TD, PAZDERKA J, HALLORAN PE Calcineurin activity is only partially inhibited in leukocytes of cyclosporine treated patients. Transplantation 1995: 59: 1400.
    • (1995) Transplantation , vol.59 , pp. 1400
    • Batiuk, T.D.1    Pazderka, J.2    Halloran, P.E.3
  • 25
    • 13344258876 scopus 로고
    • The cytosolic-binding protein for the immunosuppressant FK506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans-isomerase
    • SIEKERA JJ, WIEDERECHT G, GRENLICH G, et al. The cytosolic-binding protein for the immunosuppressant FK506 is both a ubiquitous and highly conserved peptidyl-prolyl cis-trans-isomerase. J Biol Chem 1990: 265: 2101.
    • (1990) J Biol Chem , vol.265 , pp. 2101
    • Siekera, J.J.1    Wiederecht, G.2    Grenlich, G.3
  • 28
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • LIU J, FARMER JD JR, LANE WS, et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991: 66: 807.
    • (1991) Cell , vol.66 , pp. 807
    • Liu, J.1    Farmer Jr., J.D.2    Lane, W.S.3
  • 29
    • 0008755365 scopus 로고
    • Advances in therapeutic immunosuppression: Biology, molecular actions, and clinical implications
    • BIERER BE. Advances in therapeutic immunosuppression: biology, molecular actions, and clinical implications. Curr Opin Hematol 1993: 149.
    • (1993) Curr Opin Hematol , pp. 149
    • Bierer, B.E.1
  • 30
    • 0026780166 scopus 로고
    • The spectrum of action of new immunosuppressive drugs
    • THOMSON AW. The spectrum of action of new immunosuppressive drugs. Clin Exp Immunol 1992: 89: 170.
    • (1992) Clin Exp Immunol , vol.89 , pp. 170
    • Thomson, A.W.1
  • 31
  • 32
    • 0026659046 scopus 로고
    • Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kD S6 protein kinases
    • CHUNG J, KUO CJ, CRABTREE GR, et al. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kD S6 protein kinases. Cell 1992: 69: 1227.
    • (1992) Cell , vol.69 , pp. 1227
    • Chung, J.1    Kuo, C.J.2    Crabtree, G.R.3
  • 33
    • 0026721092 scopus 로고
    • Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
    • Kuo CJ, CHUNG J, FIORENTINO DF et al. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature (London) 1992: 358: 70.
    • (1992) Nature (London) , vol.358 , pp. 70
    • Kuo, C.J.1    Chung, J.2    Fiorentino, D.F.3
  • 34
    • 0028210361 scopus 로고
    • Relationship between multiple biologic effects of rapamycin and the inhibition of p70S6 protein kinase activity
    • DUMONT FJ, ALTMEYER A, KASTNER C, et al. Relationship between multiple biologic effects of rapamycin and the inhibition of p70S6 protein kinase activity. J Immunol 1994: 152: 992.
    • (1994) J Immunol , vol.152 , pp. 992
    • Dumont, F.J.1    Altmeyer, A.2    Kastner, C.3
  • 35
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • SABATINI DM. ERDJUMENT-BROMAGE H, LUI M, et al. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994: 78: 35.
    • (1994) Cell , vol.78 , pp. 35
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3
  • 36
    • 0028360374 scopus 로고
    • A mammalian protein targeted by G1-arresting rapamycin-receptor complex
    • BROWNE EJ, ALBERS MW, SHIN TB, et al. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature (London) 1994: 369: 756.
    • (1994) Nature (London) , vol.369 , pp. 756
    • Browne, E.J.1    Albers, M.W.2    Shin, T.B.3
  • 37
    • 0029071264 scopus 로고
    • TOR kinase domains are required for two distinct functions. only one of which is inhibited by rapamycin
    • ZHENG XF, et al. TOR kinase domains are required for two distinct functions. only one of which is inhibited by rapamycin. Cell 1995: 82: 121.
    • (1995) Cell , vol.82 , pp. 121
    • Zheng, X.F.1
  • 38
    • 0025990313 scopus 로고
    • New horizons in immunosuppression
    • SIMMONS RL, WANG SC New horizons in immunosuppression. Transplant Proc 1991: 23: 2152.
    • (1991) Transplant Proc , vol.23 , pp. 2152
    • Simmons, R.L.1    Wang, S.C.2
  • 39
    • 0027309093 scopus 로고
    • Renal transplantation: Is the impact of new molecules acting on the immune system already clinically measurable?
    • MUNN SR. Renal transplantation: is the impact of new molecules acting on the immune system already clinically measurable? J Nephrol 1994: 6: 6.
    • (1994) J Nephrol , vol.6 , pp. 6
    • Munn, S.R.1
  • 40
    • 0027184873 scopus 로고    scopus 로고
    • Mechanism of action of 15 eoxyspergualin, a novel immunosuppressive drug
    • TEPPER MA, NADLER SG, MAZZUCCO C, et al. Mechanism of action of 15 eoxyspergualin, a novel immunosuppressive drug. Ann NY Acad Sci 685: 136.
    • Ann NY Acad Sci , vol.685 , pp. 136
    • Tepper, M.A.1    Nadler, S.G.2    Mazzucco, C.3
  • 41
    • 0026526303 scopus 로고    scopus 로고
    • Interaction of the immunosuppressant deoxyspergualin with a member of the hsp70 family of heat shock proteins
    • NADLER SG, TEPPER MA, SCHACTER B, MAZZUCCO CE. Interaction of the immunosuppressant deoxyspergualin with a member of the hsp70 family of heat shock proteins. Science 258: 484.
    • Science , vol.258 , pp. 484
    • Nadler, S.G.1    Tepper, M.A.2    Schacter, B.3    Mazzucco, C.E.4
  • 42
    • 0026567911 scopus 로고
    • A case for chaperones in antigen processing
    • DE NAGEL DC, PIERCE SK. A case for chaperones in antigen processing. Immunol Today 1992: 13: 86.
    • (1992) Immunol Today , vol.13 , pp. 86
    • De Nagel, D.C.1    Pierce, S.K.2
  • 43
    • 0028029788 scopus 로고
    • The immunosuppressant deoxyspergualin (DSG) inhibits antigen processing in monocytes
    • HOEGER PH. TEPPER MA, FAITH A. et al. The immunosuppressant deoxyspergualin (DSG) inhibits antigen processing in monocytes. J Immunol 1994: 153: 3908.
    • (1994) J Immunol , vol.153 , pp. 3908
    • Hoeger, P.H.1    Tepper, M.A.2    Faith, A.3
  • 44
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NK-κB activity through induction of IκB synthesis
    • AUPHAN N. DI DONATO JA, ROSETTE C, HELMBERG A, KARIN M. Immunosuppression by glucocorticoids: inhibition of NK-κB activity through induction of IκB synthesis. Science 1995: 270: 286.
    • (1995) Science , vol.270 , pp. 286
    • Auphan, N.1    Di Donato, J.A.2    Rosette, C.3    Helmberg, A.4    Karin, M.5
  • 45
    • 0028879819 scopus 로고
    • Role of transcriptional activation of TκBα in mediation of immunosuppression by glucocorticoids
    • SCHEINMAN RI. COGSWELL PC. LOFQUIST AK, BALDWIN AS Jr. Role of transcriptional activation of TκBα in mediation of immunosuppression by glucocorticoids. Science 1995: 270: 283.
    • (1995) Science , vol.270 , pp. 283
    • Scheinman, R.I.1    Cogswell, P.C.2    Lofquist, A.K.3    Baldwin Jr., A.S.4


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