Thyroid hormone metabolism and action in the brain and pituitary

Acta Medica Austriaca

Volumn 27, Issue 1, 2000, Pages 1-7

  Kohrle J ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Brain; Deiodinase; Metabolism action; Pituitary; Receptor; Thyroid hormone

Indexed keywords

THYROID HORMONE; THYROID HORMONE RECEPTOR;

ANIMAL; BRAIN; FETUS; HUMAN; HYPOPHYSIS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; REVIEW; TRANSGENIC MOUSE;

ANIMALS; BRAIN; FETUS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PITUITARY GLAND; RECEPTORS, THYROID HORMONE; THYROID HORMONES;

EID: 0033650063     PISSN: 03038173     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1563-2571.2000.00101.x     Document Type: Article

References (68)

1. Arem R, Wiener GJ, Kaplan SG, Kim HS, Reichlin S, Kaplan MM: Reduced tissue thyroid hormone levels in fatal illness. Metabolism 1993;42: 1102-1108.
2. Barker SB, Klitgaard HM: Metabolism of tissues excised from thyroxine-injected rats. Am J Physiol 1952; 170:81-86.
3. Bates JM, St. Germain DL, Galton VA: Expression profiles of three iodothyronine deiodinases D1, D2, D3, in the developing rat. Endocrinology 1999;140:844-851.
4. Baumgartner A, Hiedra L, Pinna G, Eravci M, Prengel H, Meinhold H: Rat brain type II 5'-deiodinase activity is extremely sensitive to stress. J Neurochem 1998;71:817-826.
5. Baumgartner A, Pinna G, Hiedra L, Gaio U, Hessenius C, Campos Barros A, Eravci M, Prengel H, Thoma R, Meinhold H: Effects of lithium and carbamazepine on thyroid hormone metabolism in rat brain. Neuropsychopharmacology 1997;16:25-41.
6. Baur A, Bauer K, Jarry H, Köhrle J: 3,5-Di-iodo-L-thyronine stimulates type I 5'-deiodinase activity in rat anterior pituitaries in vivo and in reaggregate cultures and GH3 cells in vitro. Endocrinology 1997;138:3242-3248.
7. Baur A, Köhrle J: Type I 5'-deiodinase is stimulated by iodothyronines and involved in thyroid hormone metabolism in human somatomammotroph GX cells. Eur J Endocrinol 1999;367-370.
8. Bermano G, Nicol F, Dyer JA, Sunde RA, Beckett GJ, Arthur JR, Hesketh JE: Selenoprotein gene expression during selenium-repletion of selenium-deficient rats. Biol Trace Elem Res 1996;51:211-223.
9. Bernal J, Nunez J: Thyroid hormones and brain development. Eur J Endocrinol 1995;133:390-398.
10. Breen J, Hickok N, Gurr JA: The rat TSH gene contains distinct response elements for regulation by retinoids and thyroid hormone. Molecular and Cellular Endocrinology 1997; 131:137-146.
11. Calvo RM, Roda JM, Obregon MJ, Morreale de Escobar G: Thyroid hormones in human tumoral and normal nervous tissues. Brain Research 1998;801:150-157.
12. Campos-Barros A, Hoell T, Musa A, Sampaolo S, Stoltenburg G, Pinna G, Eravci M, Meinhold H, Baumgartner A: Phenolic and tyrosyl ring deiodination and thyroid hormone concentrations in the human central nervous system. J Clin Endocrinol Metab 1996;81:2179-2185.
13. Campos-Barros A, Musa A, Flechner A, Hessenius C, Gaio U, Meinhold H, Baumgartner A: Evidence for circadian variations of thyroid hormone concentrations and type II 5'-iodothyronine deiodinase acticity in the rat central nervous system. J Neurochem 1997;68:795-803.
14. Davis PJ, Davis FB: Nongenomic actions of thyroid hormone. Thyroid 1996;6:497-504.
15. Diano S, Naftolin F, Goglia F, Csernus V, Horvath TL: Monosynaptic pathway between the arcuate nucleus expressing glial type II iodothyronine 5'-deiodinase mRNA and the median eminence-projective TRH cells of the rat paraventricular nucleus. J Neuroendocrinol 1998;10:731-742.
16. Dratman MB, Crutchfield FL, Schoenhoff MB: Transport of iodothyronines from bloodstream to brain: contributions by blood: brain and choroid plexus: cerebrospinal fluid barriers. Brain Res 1991;554:229-236.
17. Ercan-Fang S, Schwartz HL, Oppenheimer JH: Isoform-specific 3,5,3'-triiodothyronine receptor binding capacity and messenger ribonucleic acid content in rat adenohypophysis: effect of thyroidal state and comparison with extrapituitary tissues. Endocrinology 1996;137:3228-3233.
18. Escobar-Morreale HF, Obregón MJ, Escobar del Rey F, Morreale de Escobar G: Tissue-specific patterns of changes in 3,5,3'-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. Which are the regulatory mechanisms? Biochimie 1999;81: 453-462.
19. Farsetti A, Desvergne B, Hallenbeck P, Robbins J, Nikodem VM: Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoter. J Biol Chem 1992;267:15784-15788.
20. Forrest D, Erway LC, Ng L, Altschuler R, Curran T: Thyroid hormone receptor is essential for development of auditory function. Nat Genet 1996; 13:354-357.
21. Forrest D, Golarai G, Connor J, Curran T: Genetic analysis of thyroid hormone receptors in development and disease. Recent Prog Horm Res 1996; 51:1-22.
22. Forrest D, Hanebuth E, Smeyne RJ, Everds N, Stewart CL, Wehner JM, Curran T: Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor: Evidence for tissue-specific modulation of receptor function. EMBO Journal 1996;15:3006-3015.
23. Fraichard A, Chassande O, Plateroti M, Roux JP, Troillas J, Dehay C, Legrand C, Gauthier K, Kedinger M, Malaval L, Rousset B, Samarut J: The T3Rα gene encoding a thyroid hormone receptor is essential for post- natal development and thyroid hormone production. EMBO J 1997;16:4412-4420.
24. Gauthier K, Chassande O, Plateroti M, Roux J-P, Legrand C, Pain B, Roussel B, Weiss R, Truillas J, Samarut J: Different functions for the thyroid hormone receptors TRα and TRβ in the control of thyroid hormone production and post-natal development. EMBO J 1999;18:623-631.
25. Giordano T, Pan JB, Casuto D, Watanabe S, Arneric SP: Thyroid hormone regulation of NGF, NT-3 and BDNF RNA in the adult rat brain. Brain Res Mol Brain Res 1992;16:239-245.
26. Gordon JT, Martens DA, Tomlinson EE, Greenberg J, Dratman MB: Desmethylimipramine, a potent inhibitor of synaptosomal norepinephrine uptake, has diverse effects on thyroid hormone processing in rat brain. II. Effect on in vivo 5'-deiodination of [125I]thyroxine. Brain Res 1994;634:96-104.
27. Göthe S, Wang Z, Ng L, Kindblom JM, Campos-Barros A, Ohlsson C, Vennström B, Forrest D: Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation. Genes Dev 1999; 13:1329-1341.
28. Guadano-Ferraz A, Bernal J: Regional expression of 5'-deiodinase II in the rat brain as studied by in situ hybridization. Proc Natl Acad Sci USA 1997;94:10391-10396.
29. Guadano-Ferraz A, Escamez, MJ, Rausell E, Bernal J: Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. J Neurosci 1999;19:3430-3439.
30. Iniguez MA, de Lecea L, Guadano-Ferraz A, Morte B, Gerendasy D, Sutcliffe JG, Bernal J: Cell- specific effects of thyroid hormone on RC3/neurogranin expression in rat brain. Endocrinology 1996; 137:1032-1041.
31. Koenig RJ, Leonard JL, Senator D, Rappaport N, Watson A, Larsen PR: Regulation of thyroxine 5'- deiodinase activity by 3,5,3'-triiodothyronine in cultured anterior pituitary cells. Endocrinology 1984;115:324-329.
32. Ködding R, Fuhrmann H, Von zur Mühlen A: Investigations on iodothyronine deiodinase activity in the maturing rat brain. Endocrinology 1986; 118:1347-1352.
33. Köhrle J: The trace element selenium and the thyroid gland. Biochimie 1999;527-533.
34. Köhrle J: Local activation and inactivation of thyroid hormones: the deiodinase family. Mol Cell Endocrinol 1999;151:103-119.
35. Köhrle J, Schomburg L, Drescher S, Fekete E, Bauer K: Rapid stimulation of type I 5'-deiodinase in rat pituitaries by 3,3',5-triiodo-L-thyronine. Mol Cell Endocrinol 1995;108:17-21.
36. Larsen PR, Silva JE, Kaplan MM: Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev 1981;2:87-102.
37. Lechan RM, Qi Y, Berrodin TJ, Davis KD, Schwartz HL, Strait KA, Oppenheimer JH, Lazar MA: Immunocytochemical delineation of thyroid hormone receptor beta 2-like immunoreactivity in the rat central nervous system. Endocrinology 1993;132:2461-2469.
38. Legrand C, Clos J: Biochemical, immunocytochemical and morphological evidence for an interaction between thyroid hormone and nerve growth factor in the developing cerebellum of normal and hypothyroid rats. Dev Neurosci 1991;13:382-396.
39. Legrand J, Yanai J (ed): Neurobehavioral Teratology. Amsterdam, Elsevier Science Publishers, 1984:331-363.
40. Leonard JL: Identification and structure analysis of iodothyronine deiodinases, in Greer MA (ed): The Thyroid Gland. 1991:285-321.
41. Leonard JL, Farwell AP: Thyroid hormone-regulated actin polymerization in brain. Thyroid 1997;7:147-151.
42. Leonard JL, Köhrle J: Intracellular pathways of iodothyronine metabolism, in Braverman LE, Utiger RD (eds): Werner and Ingbar's The Thyroid - A Fundamental and Clinical Text. Philadelphia. Lippincott, 1996:125-161 and 8th cd. 2000 (in press)
43. Leonard JL, Leonard DM, Safran M, Wu R, Zapp ML, Farwell AP: The mammalian homolog of the frog type II selenodeiodinase does not encode a functional enzyme in the rat. Endocrinology 1999; 140:2206-2215.
44. Li PP, Andreopoulos S, Wong CC, Vecil GG, Warsh JJ: Effect of thyroid deficiency on Go alpha- subunit isoforms in developing rat cerebral cortex. Neurochemical Research 1995;20:1249-1255.
45. Lin H-Y, Davis FB, Gordinier JK, Martino LJ, Davis PJ: Thyroid hormone induces activation of mitogen- activated protein kinase in cultured cells. Am J Physiol Cell Physiol 1999;276:C1014-C1024.
46. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schütz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM: The nuclear receptor superfamily: the second decade. Cell 1995;83:835-839.
47. Munoz A, Bernal J: Biological activities of thyroid hormone receptors. Eur J Endocrinol 1997; 137:433-445.
48. Oppenheimer JH, Schwartz HL: Molecular Basis of Thyroid Hormone-Dependent Brain Development. Endocr Rev 1997;18:462-474.
49. Pallud S, Ramaugé M, Gavaret J-M, Lennon A-M, Munsch N, St. Germain DL, Pierre M, Courtin F: Regulation of type 3 iodothyronine deiodinase expression in cultred rat astrocytes: role of the Erk cascade. Endocrinology 1999;140:2917-2923.
50. Pharoah POD, Buttfield IH, Hetzel BS: Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet 1971;308-310.
51. Porterfield SP, Hendrich CE: The role of thyroid hormones in prenatal and neonatal neurological development - Current perspectives. Endocr Rev 1993;14:94-106.
52. Puymirat J: Thyroid receptors in the rat brain. Prog Neurobiol 1992;39:281-294.
53. Ramauge M, Pallud S, Esfandari A, Gavaret J-M, Lennon A-M, Pierre M, Courtin F: Evidence that type III iodothyronine deiodinase in rat astrocyte is a selenoprotein. Endocrinology 1996;137:3021-3025.
54. Salvatore D, Tu H, Harney JW, Larsen PR: Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest 1996;98:962-968.
55. Sarkar PK, Ray AK: Synaptosomal T3 content in cerebral cortex of adult rat in different thyroidal states. Neuropsychopharmacology 1994;11: 151-155.
56. Schreiber G, Southwell BR, SJ: Hormone delivery systems to the brain - transthyretin. Exp Clin Endocrinol 1995;103:75-80.
57. Stahl JH, Kendall SK, Brinkmeier ML, Greco TL, Watkins-Chow DE, Campos-Barros A, Lloyd RV, Camper SA: Thyroid hormone is essential for pituitary somatotropes and lactotropes. Endocrinology 1999;140:1884-1892.
58. Stein SA, Shanklin DR, Adams PM, Mihailoff GM, Palnitkar MB, Anderson B: Thyroid hormone regulation of specific mRNAs in the developping rat brain, in Delong GR, Robbins J, Condliffe PG (eds): Iodine and the brain. New York, Plenum Press, 1989:
59. Steinfelder JH, Wondisford FE: Thyrotropin (TSH) - subunit gene expression - an example for the complex regulation of pituitary hormone genes. Exp Clin Endocrinol Diabetes 1997;105:196-203.
60. Ting Y-T, Bhat MK, Wong R, Cheng S-Y: Tissue-specific stabilization of the thyroid hormone β1 nuclear receptor by phosphorylation. J Biol Chem 1997;272:4129-4134.
61. Tu HM, Legradi G, Bartha T, Salvatore D, Lechan RM, Larsen PR: Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology 1999;140:784-790.
62. Vega-Nunez E, Menendez-Hurtado A, Garesse R, Santos A, Perez-Castillo A: Thyroid hormone- regulated brain mitochondrial genes revealed by differential cDNA cloning. J Clin Invest 1995;96:893-899.
63. Visser TJ, Kaplan MM, Leonard JL, Larsen PR: Evidence for two pathways of iodothyronine 5'deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest 1983;71:992-1002.
64. Weiss RE, Forrest D, Pohlenz J, Cua K, Curran T, Refetoff S: Thyrotropin regulation by thyroid hormone in thyroid hormone receptor β1-deficient mice. Endocrinology 1997;138:3624-3629.
65. Weiss RE, Refetoff S: Editorial: Treatment of resistance to thyroid hormone - primum non nocere. J Clin Endocrinol Metab 1999;84:401-404.
66. Weiss RE, Xu J, Ning G, Pohlenz J, O'Malley BW, Refetoff S: Mice deficient in the steroid receptor co- activator 1 (SRC-1) are resistant to thyroid hormone. EMBO J 1999;18:1900-1904.
67. Wrutniak C, Cassar Malek I, Marchal S, Rascle A, Heusser S, Keller J-M, Fléchon J, Dauca M, Samarut J, Ghysdael J, Cabello G: A 43-kDa protein related to c-Erb A 1 is located in the mitochondrial matrix of rat liver. J Biol Chem 1995;270:16347-16354.
68. Yusta B, Alarid ET, Gordon DF, Ridgway EC, Mellon PL: The thyrotropin β-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line mouse TαTI cells. Endocrinology 1998;139:4476-4482.