The mammalian homolog of the frog type II selenodeiodinase does not encode a functional enzyme in the rat

Endocrinology

Volumn 140, Issue 5, 1999, Pages 2206-2215

  Leonard, Jack L ^a   Leonard, Deborah M ^b   Safran, Marjorie ^b   Wu, Rui ^a   Zapp, Maria L ^a   Farwell, Alan P ^b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

THYROXINE DEIODINASE;

ADIPOCYTE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ASTROCYTE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEIODINATION; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; THYROID HORMONE METABOLISM;

EID: 0033325106     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.5.6727     Document Type: Article

References (46)

1. Biochemical basis of deiodination
2. Identification and structure analysis of thyroid hormone deiodinases
3. Iodothyronine deiodinases
4. Comparison of the physicochemical properties of type I and type II iodothyronine 5'-deiodinase
5. Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex
6. Thyroxine targets different pathways of internalization of type II iodothyronine 5'-deiodinase in astrocytes
7. Regulation of type II iodothyronine 5'-deiodinase by thyroid hormone. Inhibition of actin polymerization blocks enzyme inactivation in cAMP-stimulated glial cells
8. Thyroxine-dependent modulation of actin polymerization in cultured astrocytes. A novel, extranuclear action of thyroid hormone
9. Regulation of rat cerebrocortical and adenohypophyseal type II 5'-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine
10. Acute post-transcriptional regulation of cerebrocortical and pituitary iodothyronine 5'-deiodinases by thyroid hormone
11. Cerebral cortex responds rapidly to thyroid hormones
12. Evidence that type II 5'-deiodinase is not a selenoprotein
13. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
14. A thyroid hormone-regulated gene in Xenopus laevis encodes a type 11I iodothyronine 5-deiodinase
15. Cloning and expression of a cDNA for a mammalian type Ill iodothyronine deiodinase
16. Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase
17. Type 3 iodothyronine deiodinase: Cloning, in vitro expression, and functional analysis of the placental selenoenzyme
18. Effects of selenium deficiency on thyroid hormone economy in rats
19. Effects of selenium and iodine deficiency on type I, type II and type III iodothyronine deiodinases and circulating thyroid hormones in the rat
20. The role of selenium in thyroid hormone metabolism
21. Effects of combined iodine and selenium deficiency on thyroid hormone metabolism in rats
22. Identification of a 27-kDa protein with the properties of type 1I iodothyronine 5'-deiodinase in dibutyryl cyclic AMP-stimulated glial cells
23. Catalytic activity of type II iodothyronine 5'-deiodinase polypeptide is dependent upon a cyclic AMP activation factor
24. Selenium deficiency and type II 5'-deiodinase regulation in the euthyroid and hypothyroid rat: Evidence of a direct effect of thyroxine
25. Effects of selenium deficiency on thyroid hormone economy in rats
26. Cloning of a cDNA for the type II iodothyronine deiodinase
27. Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in human and rat brain and other tissues
28. Hepatic iodothyronine 5-deiodinase activity in Rana catesbeiana tadpoles at different stages of the life cycle
29. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region
30. Selenium-regulated translation control of heterologous gene expression: Normal function of selenocysteine-substituted gene products
31. Molecular biological and biochemical characterization of the human type 2 selenodeiodinase
32. Inhibition of thyroxine 5'-deiodination type II in cultured human placental cells by cortisol, insulin, 3',5'-cyclic adenosine monophosphate, and butyrate
33. Affinity labeling of rat liver and kidney type 15' deiodinase identification of the 27-kda substrate binding subunit
34. Dibutyryl cAMP induction of type 115'deiodinase activity in rat brain astrocytes in culture
35. Single step RNA isolation from cultured cells and tissues
36. Immunoscreening after hybrid selection and translation
37. On the relationship between preferred termination codon contexts and nonsense suppression in human cells
38. Influence of codon context on UGA suppression and readthrough
39. Analysis of eukaryotic mRNA structures directing cotranslational incorporation of selenocysteine
40. Characterization of a propyl-thiouracil-insensitive type I iodothyronine deiodinase
41. The role of conserved AAUAAA sequence: Four AAUAAA point mutants prevent messenger RNA 3' end formation
42. Iodothyronine 5'-deiodinase in brown adipose tissue: Thiol activation and propylthiouracil inhibition
43. Iodothyronine 5'-deiodinase in rat kidney microsomes. Kinetic behavior at low substrate concentrations
44. Iodothyronine 5'-deiodination in rat kidney microsomes: Sensitivity to propylthiouracil
45. Expression of the type II iodothyronine deiodinase in cultured rat astrocytes is selenium-dependent
46. Thyroid hormone metabolism in primary cultures of fetal rat brain cells