The Leishmania promastigote surface antigen-2 (PSA-2) is specifically recognised by Th1 cells in humans with naturally acquired immunity to L. major

FEMS Immunology and Medical Microbiology

Volumn 20, Issue 3, 1998, Pages 209-218

  Kemp, Michael ^a   Handman, Emanuela ^b   Kemp, Kåre ^a   Ismail, Ahmed ^a,c   Mustafa, Mustafa D ^c   Kordofani, Anuar Y ^c   Bendtzen, Klaus ^d   Kharazmi, Arsalan ^a   Theander, Thor G ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF KHARTOUM   (Sudan)

^d Rigshospitalet   (Denmark)

Author keywords

Interferon ; Interleukin 4; Legshmania major; Th1; Tumor necrosis factor

Indexed keywords

CD3 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; LYMPHOTOXIN; PARASITE ANTIGEN; TETANUS TOXOID; TUBERCULIN; VACCINE;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEISHMANIA MAJOR; LEISHMANIASIS; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; PRIORITY JOURNAL; PROMASTIGOTE; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD3; ANTIGENS, PROTOZOAN; ANTIGENS, SURFACE; FLOW CYTOMETRY; HUMANS; IMMUNITY, ACTIVE; INTERFERON TYPE II; INTERLEUKIN-4; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; LYMPHOTOXIN-ALPHA; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; SUDAN; TH1 CELLS;

EID: 0031940082     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(98)00015-7     Document Type: Article

References (25)

1. Kemp, M., Theander, T.G. and Kharazmi, A. (1996) The contrasting roles of CD4+ T cells in intracellular infections in humans: Leishmaniasis as an example. Immunol. Today 17, 13-16.
2. Kemp, M., Hey, A.S., Kurtzhals, J.A., Christensen, C.B., Gaafar, A., Mustafa, M.D., Kordofani, A.A., Ismail, A., Kharazmi, A. and Theander, T.G. (1994) Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis. Clin. Exp. Immunol. 96, 410-415.
3. Kemp, M., Hey, A.S., Bendtzen, K., Kharazmi, A. and Theander, T.G. (1994) Th1-like human T-cell clones recognizing Leishmania gp63 inhibit Leishmania major in human macrophages. Scand. J. Immunol. 40, 629-635.
4. Gaafar, A., Kharazmi, A., Ismail, A., Kemp, M., Hey, A., Christensen, C.B.V., Dafalla, M., El-Kadaro, A.Y., El-Hassan, A.M. and Theander, T.G. (1995) Dichotomy of the T-cell response to Leishmania antigens in patients suffering from cutaneous leishmaniasis: absence or scarcity of Th1 activity is associated with severe infections. Clin. Exp. Immunol. 100, 239-245.
5. Morris, L., Aebisher, T., Handman, E. and Kelso, A. (1993) Resistance of BALB/c mice to Leishmania major infection is associated with a decrease in the precursor frequency of antigen-specific CD4+ cells secreting interleukin-4. Int. Immunol. 5, 761-767.
6. Morris, L., Troutt, A., Handman, E. and Kelso, A. (1996) Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4+ cells correlate with resolution of lesions in murine cutaneous leishmaniasis. J. Immunol. 149, 2715-2721.
7. Murphy, E.E., Shibuya, K., Hosken, N.A., Openshaw, P., Maino, V., Davis, K., Murphy, K. and O'Garra, A. (1996) Reversibility of T helper 1 and 2 populations is lost after long term stimulation. J. Exp. Med. 183, 901-913.
8. O'Garra, A. and Murphy, K. (1994) Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol. 6, 466.
9. Handman, E., Symons, F.M., Baldwin, T.M., Curtis, J.M. and Scheerlinck, J.P. (1995) Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response. Infect. Immun. 63, 4261-4267.
10. Murray, P.J., Spithill, T.W. and Handman, E. (1989) The PSA-2 glycoprotein complex of Leishmania major is a glycosylphosphatidylinositol-linked promastigote surface antigen. J. Immunol. 143, 4221-4226.
11. Symons, F.M., Murray, P.J., Ji, H., Simpson, R.J., Osborn, A.H., Cappai, R. and Handman, E. (1994) Characterization of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species. Mol. Biochem. Parasitol. 67, 103-113.
12. McMahon Pratt, D., Traub-Cseko, Y., Lohman, K.L., Rogers, D.D. and Beverley, S.M. (1992) Loss of the GP46/M-2 surface glycoprotein gene family in the Leishmania braziliensis complex. Mol. Biochem. Parasitol. 50, 151-160.
13. Kadaro, A.Y., Ghalib, H.W., Ali, M.S., El-Toum, I., Ismail, A., Gaafar, A., Kemp, M., Kordofani, A.A.Y., Reed, S., El-Hassan, A.M., Kharazmi, A., Hag-Ali, M. and Mustafa, M.D. (1993) Prevalence of cutaneous leishmaniasis along the Nile river North of Khartoum (Sudan) in the aftermath of an epidemic in 1985. Am. J. Trop. Med. Hyg. 48, 44-49.
14. Kurtzhals, J.A.L., Hansen, M.B., Hey, A. and Poulsen, L.K. (1992) Measurement of antigen-dependent interleukin-4 production by human peripheral blood mononuclear cells - Introduction of an amplification step using ionomycin and phorbol myristate acetate. J. Immunol. Methods 156, 239-245.
15. Champsi, J. and McMahon Pratt, D. (1988) Membrane glycoprotein M-2 protects against Leishmania amazonensis infection. Infect. Immun. 52, 3272-3279.
16. McMahon Pratt, D., Rodriguez, D., Rodriguez, J.-R., Zhang, Y., Manson, K., Bergman, C., Rivas, L., Rodriguez, J.F., Lohman, K.L., Ruddle, N.H. and Esteban, M. (1993) Recombinant vaccinia viruses expressing gp46/M-2 protect against Leishmania infection. Infect. Immun. 61, 3351-3359.
17. Kemp, M., Kurtzhals, J.A., Bendtzen, K., Poulsen, L.K., Hansen, M.B., Koech, D.K., Kharazmi, A. and Theander, T.G. (1993) Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis. Infect. Immun. 61, 1069-1073.
18. Kelso, A. (1995) Th1 and Th2 subsets: paradigm lost? Immunol. Today 16, 374-379.
19. Jung, T., Schauer, U., Rieger, C., Wagner, K., Einsle, K., Neumann, C. and Heusser, C. (1995) Interleukin-4 and interleukin-5 are rarely co-expressed by human T cells. Eur. J. Immunol. 25, 2413-2416.
20. Schauer, U., Jung, T., Krug, N. and Frew, A. (1996) Measurement of intracellular cytokines. Immunol. Today 17, 305-306.
21. Kemp, K., Hviid, L., Kharazmi, A. and Kemp, M. (1997) Interferon-gamma production by T cells and NK cells in vitro in response to antigens from the two intracellular pathogens Mycobacterium tuberculosis and Leishrnania major. Scand. J. Immunol. 46, 495-499.
22. Haurum, J.S., Arsequell, G., Lellouch, A.C., Wong, S.Y.C., Dwek, R.A., McMichael, A.J. and Elliott, T. (1994) Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes. J. Exp. Med. 180, 739-744.
23. Jensen, T., Galli-Stampino, L., Mouritsen, S., Frische, K., Peters, S., Meldal, M. and Werdelin, O. (1996) T cell recognition of Tn-glycosylated peptide antigens. Eur. J. Immunol. 26, 1342-1349.
24. Handman, E., Button, L.L. and McMaster, R.W. (1996) Leishmania major: production of recombinant gp63, its antigenicity and immunogenicity in mice. Exp. Parasitol. 70, 427-435.
25. Button, L.L., Reiner, N.E. and McMaster, R.W. (1991) Modification of gp63 genes from diverse species of Leishmania for expression of recombinant protein at high levels in Escherichia coli. Mol. Biochem. Parasitol. 44, 213-224.