Interferon-γ and tumour necrosis factor-α-producing cells in humans who are immune to cutaneous leishmaniasis

Scandinavian Journal of Immunology

Volumn 49, Issue 6, 1999, Pages 655-659

  Kemp, Kåre ^a,b   Theander, T G ^a   Hviid, L ^a   Garfar, A ^a   Kharazmi, A ^a   Kemp, M ^a  

^a Mental Health Services CPH   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; PARASITE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEISHMANIA MAJOR; MONONUCLEAR CELL; PRIORITY JOURNAL; SKIN LEISHMANIASIS; SUDAN; T LYMPHOCYTE;

CD4-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; HUMANS; IMMUNITY, NATURAL; INTERFERON TYPE II; INTERLEUKIN-10; LEISHMANIASIS, CUTANEOUS; LEUKOCYTES, MONONUCLEAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032970388     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1999.00554.x     Document Type: Article

References (22)

1. 1 Badaró R, Jones TC, Carvalho EM et al. New perspectives on a subclinical form of visceral leishmaniasis. J Infect Dis 1986;154:207-14.
2. 2 Kemp M, Hey AS, Kurtzhals JAL et al. Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis. Clin Exp Immunol 1994;96:410-3.
3. 3 Kurtzhals JAL, Hey AS, Jardim A et al. Dichotomy of the human T-cell response to Leishmania antigens. II. Absent or Th2 like response to gp63 and Th1 like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. Clin Exp Immunol 1994;96:416-21.
4. + T cells in intracellular infections in humans: leishmaniasis as an example. Immunol Today 1996;17:13-6.
5. 5 Kemp M, Handman E, Kemp K et al. The Leishmania promastigote surface antigen-2 (PSA-2) is specifically recognized by Th1 cells in humans with naturally acquired immunity to L major. FEMS Immunol Microbiol 1998;20:209-18.
6. 6 Kadaro AY, Ghalib HW, Ali MS et al. Prevalence of cutaneous leishmaniasis along the Nile river North of Khartoum (Sudan) in the aftermath of an epidemic in 1985. Am J Trop Med Hyg 1985;48:44-9.
7. 7 Theander TG. Malaria in areas of unstable and seasonal transmission lessons from Daraweesh. Trans R Soc Trop Med Hyg 1998;92:589-59 2.
8. 8 Hviid L, Albeck G, Hansen B, Theander TG, Talbot G. A new portable device for automatic controlled-gradient cryopreservation of blood mononuclear cells. J Immunol Methods 1993;157:135-42.
9. 9 Bahrenscheer J, Kemp M, Kurtzhals JAL, Gachihi GS, Kharazmi A, Theander TG. Interferon-γ and interleukin-4 production by human T cells recognizing Leishmania donovani antigens separated by SDS-PAGE. APMIS 1995;103:131-9.
10. 10 Kemp M, Theander TG, Handman E et al. Activation of human T lymphocytes by Leishmania lipophosphoglycan. Scand J Immunol 1991;33:219-24.
11. 11 Liew FY, Parkinson C, Millott S, Severn A, Carrier M. Tumor necrosis factor (TNFα) in leishmaniasis. I. TNFα mediates host protection against cutaneous leishmaniasis. Immunology 1990;69:570-573.
12. 12 Liew FY, Li T, Millott S. Tumor necrosis factor α synergies with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide. J Immunol 1990;145:4306-4310.
13. 13 Kurtzhals JAL, Kemp M, Poulsen LK, Hansen MB, Kharazmi A, Theander TG. Interleukin-4 and interferon-gamma production by Leishmania stimulated peripheral blood mononuclear cells from non-exposed individuals. Scand J Immunol 1995;41:343-9.
14. 14 Kemp K, Hviid L, Kharazmi A, Kemp M, IFN-γ production by human T cells and NK cells in vitro in response to antigens from two intracellular pathogens Mycobacterium tuberculosis and Leishmania major. Scand J Immunol 1997;46:495-500.
15. 15 Jung T, Schauer U, Heusser C, Neumann C, Rieger C. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993;159:197-207.
16. 16 Prussin C, Metcalfe DD. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Methods 1995;188:117-28.
17. 17 Schauer U, Jung T, Krug N, Frew A. Measurement of intracellular cytokines. Immunol Today 1996;17:305-7.
18. 18 Karp CL, El-safi SH, Wynn TA et al. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J Clin Invest 1993;91:1644-8.
19. 19 Cillari E, Vitale G, Arcoleo F et al. In vivo and in vitro cytokine profiles and mononuclear subsets in Sicilian patients with active vicseral leishmaniasis. Cytokine 1995;7:740-5.
20. 20 de Mendonca SCF, Luc PM, Mayrin W et al. Characterization of human T lymphocyte-mediated immune responses induced by a vaccine against American tegumentary leishmaniasis. Am J Trop Med Hyg 1995;53:195-201.
21. + T cells associated with cure of human cutaneous leishmaniasis. Infect Immun 1994;62:2614-8.
22. 22 Kemp K et al. Leishmania-specific T cells expressing IFN-γ and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis. Clin Exp Immunol (in press).