Testosterone and frailty

Clinics in Geriatric Medicine

Volumn 13, Issue 4, 1997, Pages 685-695

  Morley, J E ^a   Kaiser, F E ^a   Sih, R ^a   Hajjar, R ^a   Perry III, H M ^a  

^a S LOUIS UNIV HLTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE;

AGING; CLINICAL FEATURE; DEMENTIA; HORMONAL THERAPY; HORMONE ACTION; HORMONE DEFICIENCY; HUMAN; IMPOTENCE; MALE; MUSCLE STRENGTH; OSTEOPENIA; REVIEW;

EID: 0031470370     PISSN: 07490690     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0749-0690(18)30144-7     Document Type: Review

References (77)

1. U. Aasebo R.M. Bremnes F.H. de Jong Pituitary-gonadal dysfunction in male patients with lung cancer: Association with serum inhibin levels Acta Oncologica 33 1994 177 180
2. A. Abbasi D.E. Mattson M. Cuisinier Hyposomatomedinemia and hypogonadism in hemiplegic men who live in nursing homes Arch Phys Med Rehabil 75 1994 595 599
3. S. Arver A.S. Dobs A.W. Meikle Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system J Urol 155 1996 1604 1608
4. W.S. Ashton B.M. Degnan A. Daniel Testosterone increases insulin-like growth factor-1 and insulin-like growth factor-binding protein Ann Clin Lab Sci 25 1995 381 388
5. H.W. Baker B. Hudson Changes in the pituitary-testicular axis with age Monogr Endocrinol 25 1983 71 83
6. H.W. Baker H.G. Burger D.M. de Kretser Changes in the pituitary-testicular system with age Clin Endocrinol 5 1976 349 372
7. D.T. Baran M.A. Bergfeld S.L. Teitelbaum Effect of testosterone therapy on bone formation in an osteoporotic hypogonadal male Calcif Tissue Int 26 1978 103 106
8. Baumgartner R, Morley JE, Garry P., Predictors of sarcopenia in the New Mexico Process Study. J Am Geriatr Soc in press, 1997.
9. S. Bhasin T.W. Störer N. Berman The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men N Engl J Med 335 1996 1 7
10. C.J. Billington R.B. Shafer J.E. Morley Effects of opioid blockade with nalmefene in older impotent men Life Sciences 47 1990 799 805
11. J.P. Devogelaer S. DeCooman C. Nagant de Deuxchaisnes Low bone mass in hypogonadal males: Effect of testosterone substitution therapy, a densitometric study Maturitas 15 1992 17 23
12. P.H. Drinka J. Olson S. Bauwens Lack of association between free testosterone and bone density separate from age in elderly males Calcif Tissue Int 52 1993 67 69
13. P.J. Drinka A.L. Jochen M. Cuisinier Polycythemia as a complication of testosterone replacement therapy in nursing home men with low testosterone levels J Am Geriatr Soc 43 1995 899 901
14. P.J. Drinka S. Voeks S. Bauwens Sensitivity and positive predictive value of clinical signs of hypogonadism in elderly men South Med J 86 1993 1264 1265
15. A.E. Field G.A. Colditz W.C. Willett The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men J Clin Endocrinol Metab 79 1994 1310 1316
16. J.S. Finkeistein A. Klibanski R.M. Neer Increases in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism J Clin Endocrinol Metab 69 1989 776 783
17. J.F. Flood J.E. Morley E. Roberts Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it Proc Natl Acad Sci USA 89 1992 1567 1571
18. J.F. Flood S.A. Farr F.E. Kaiser Age-related decrease of plasma testosterone in SAMP8 mice: Replacement improves age-related impairment of learning and memory Physiology & Behavior 57 1995 669 673
19. C. Foresta G. Ruzza R. Mioni Osteoporosis and decline of gonadal function in the elderly male Horm Res 19 1984 18 22
20. R.M. Francis M. Peacock J.E. Aaron Osteoporosis in hypogonadal men: Role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption, and low bone formation Bone 7 1986 261 268
21. D. Gordon G.H. Beastall J.A. Thomson Prolonged hypogonadism in male patients with rheumatoid arthritis during flares in disease activity Br J Rheumatol 27 1988 440 444
22. A. Gray H.A. Feldman J.B. McKinlay Age, disease, and changing sex hormone levels in middle-aged men: Results of the Massachusetts Male Aging Study J Clin Endocrinol Metab 73 1991 1016 1025
23. J.M. Gray A.A. Nunez L.I. Siegel Effects of testosterone on body weight and adipose tissue: Role of aromatization Physiol Behav 23 1979 465 469
24. R.C. Griggs S. Pandya J.M. Florence Randomized controlled trial of testosterone in myotonic dystrophy Neurology 39 1989 219 222
25. M. Haji S. Tanaka Y. Nishi Sertoli cell function declines earlier than Leydig cell function in aging Japanese men Maturitas 18 1994 143 153
26. R. Hajjar F. Kaiser J.E. Morley Outcomes of long term testosterone treatment in older males J Am Geriatr Soc 43 1995 SA23
27. M.C. Hallberg R.G. Wieland E.M. Zorn Impaired Leydig cell reserve and altered serum androgen binding in the aging male Fertil Steril 27 1976 812 814
28. J. Hartnell S.G. Korenman S.P. Viosca Results of testosterone enanthate therapy for hypogonadism in older men. The Endocrine Society 72nd Annual Meeting Atlanta (abstract #428) 1990
29. J.A. Jackson M.W. Riggs A.M. Spiekerman Testosterone deficiency as a risk factor for hip fractures in men: A case-control study Am J Med Sci 304 1992 4 8
30. J.S. Jankowsky S.K. Oviatt E.S. Orwoll Testosterone influences spatial cognition in older men Behav Neurosci 108 1994 325 332
31. J.O. Jorgensen N. Vahl T.B. Hansen Influence of growth hormone and androgens on body composition in adults [review] Horm Res 45 1996 94 98
32. F.E. Kaiser S.P. Viosca J.E. Morley Impotence and aging: Clinical and hormonal factors J Am Geriatr Soc 36 1988 511 519
33. P.J. Kelly N.A. Pocock P.N. Sambrook Dietary calcium, sex hormones, and bone mineral density in men Br Med J 300 1990 1361 1364
34. S.G. Korenman J.E. Morley A.D. Mooradian Secondary hypogonadism in older men: Its relation to impotence J Clin Endocrinol Metab 71 1990 963 969
35. P. Marin H. Kvist G. Lindstedt Low concentrations of insulin-like growth factor-I in abdominal obesity Int J Obes Relat Metab Disord 17 1993 83 89
36. D.E. Meier E.S. Orwoll E.J. Keenan Marked decline in trabecular bone mineral content in healthy men with age: Lack of association with sex steroid levels J Amer Geriatr Soc 35 1987 189 197
37. A.W. Meikle N.A. Mazer J.F. Moellmer Enhanced transdermal delivery of testosterone across nonscrotal skin produces physiological concentrations of testosterone and its metabolites in hypogonadal men J Clin Endocrinol Metabol 74 1992 623 628
38. S.W. Meikle S. Arver A.S. Dobs Pharmacokinetics and metabolism of a permeationenhanced testosterone transdermal system in hypogonadal men: Influence of application site—a clinical research center study J Clin Endocrinol Metabol 81 1996 1832 1840
39. E.N. Meilahn J.A. Cauley R.P. Tracy Association of sex hormones and adiposity with plasma levels of fibrinogen and PAI-1 in postmenopausal women Am J Epidemiol 143 1996 159 166
40. N. Mikuma Y. Kumamoto H. Maruta Role of the hypothalamic opioidergic system in the control of gonadotropin secretion in elderly men Andrologia 26 1994 39 45
41. R. Mitchell S. Hollis C. Rothwell Age related changes in the pituitary-testicular axis in normal men: Lower serum testosterone results from decreased bioactive LH drive Clin Endocrinol 42 1995 501 507
42. V. Montanini M. Simoni G. Chiossi Age-related changes in plasma dehydroepi-androsterone sulphate, cortisol, testosterone and free testosterone circadian rhythms in adult men Horm Res 29 1988 1 6
43. A.D. Mooradian J.E. Morley S.G. Korenman Biological actions of androgens Endocr Rev 8 1987 1 18
44. A. Morgentaler C.O. Brüning W.C. DeWolf Occult prostate cancer in men with low serum testosterone levels JAMA 276 1996 1904 1906
45. J.E. Morley Anorexia in older persons: Epidemiology and optimal treatment Drugs Aging 8 1996 134 155
46. J.E. Morley Endocrine factors in geriatric sexuality [review] Clin Geriatr Med 7 1991 85 93
47. J.E. Morley Neuropeptide regulation of appetite and weight Endocr Rev 8 1987 256 287
48. J.E. Morley J.E. Flood Animal models of Alzheimer disease Facts and Research in Gerontology Suppl 1994 21 30
49. J.E. Morley S. Melmed Gonadal dysfunction in systemic disorders Metabol Clin Exper 28 1979 1051 1073
50. J.E. Morley A.J. Silver Anorexia in the elderly Neurobiol Aging 9 1988 9 16
51. J.E. Morley N.G. Baranetsky T.D. Wingert Endocrine effects of naloxone-induced opiate receptor blockade J Clin Endocrinol Metab 50 1980 251 257
52. J.E. Morley F.E. Kaiser H.M. Perry Longitudinal changes in testosterone luteinizing hormone and follicle stimulating hormone in healthy older males Metabolism 46 1997 410 414
53. J.E. Morley H.M. Perry III F.E. Kaiser Effects of testosterone replacement therapy in old hypogonadal males: A preliminary study J Am Geriatr Soc 41 1993 149 152
54. S. Murphy K.T. Khaw A. Cassidy Sex hormones and bone mineral density in elderly men Bone Miner 20 1993 133 140
55. K. Nahoul M. Roger Age-related decline of plasma bioavailable testosterone in adult men J Steroid Biochem 35 1990 293 299
56. H.R. Nankin J.H. Calkins Decreased bioavailable testosterone in aging normal and impotent men J Clin Endocrinol Metab 63 1986 1418 1420
57. R.W. Orrell D.F. Woodrow M.C. Barrett Testosterone deficiency myopathy J Royal Soc Med 88 1995 454 456
58. E.S. Orwoll R.F. Klein Osteoporosis in men Endocr Rev 16 1995 87 116
59. J. Pfeilschifter C. Scheidt-Nave G. Leidig-Bruckner Relationship between circulating insulin-like growth factor components and sex hormones in a population-based sample of 50- to 80-year-old men and women J Clin Endocrinol Metab 81 1996 2534 2540
60. G.B. Phillips B.H. Pinkernell T.Y. Jing The association of hypotestosteronemia with coronary artery disease in men Arterioscler Thromb 14 1994 701 706
61. I.R. Reid D.J. Wattie M.C. Evans Testosterone therapy in glucocorticoid-treated men Arch Intern Med 156 1996 1173 1177
62. J. Rissanen R. Hudson R. Ross Visceral adiposity, androgens, and plasma lipids in obese men Metabolism 43 1994 1318 1323
63. A.C. Scane A.M. Sutcliffe R.M. Francis Osteoporosis in men [review] Baillieres Clin Rheumatol 7 1993 589 601
64. R.C. Schiavi P. Schreiner-Engel D. White The relationship between pituitary-gonadal function and sexual behavior in healthy aging men Psychosom Med 53 1991 363 374
65. B.B. Sherwin T. Tulandi Add-back estrogen reverses cognitive deficits induced by a gonadotropin-releasing hormone agonist in women with leiomyomata uteri J Clin Endocr Metabol 81 1996 2545 2549
66. R. Sih J.E. Morley F.E. Kaiser Testosterone replacement in older hypogonadal men: A 12 month randomized controlled trial J Clin Endocrinol Metab 82 1997 1661 1667
67. D. Sparrow R. Bosse J.W. Rowe The influence of age, alcohol consumption, and body build on gonadal function in men J Clin Endocrinol Metab 51 1980 508 512
68. T.D. Spector L.A. Perry G. Tubb Low free testosterone levels in rheumatoid arthritis Ann Rheum Dis 47 1988 65 68
69. H.L. Stanley B.P. Schmitt R.M. Poses Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc 39 1991 766 771
70. J.S. Tenover Effects of testosterone supplementation in the aging male J Clin Endocrinol Metab 75 1992 1092 1098
71. J.S. Tenover A.M. Matsumoto S.R. Plymate The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: Response to clomiphene citrate J Clin Endocrinol Metab 65 1987 1118 1126
72. R.J. Urban Y.H. Bodenburg C. Gilkison Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis Am J Physiol 269 1995 E820 E826
73. J.D. Veldhuis R.J. Urban G. Lizarralde Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men J Clin Endocrinol Metab 75 1992 707 713
74. J.D. Veldhuis R.J. Urban M.L. Dufau Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback J Clin Endocrinol Metab 79 1994 1763 1770
75. S.J. Winters R.J. Sherins P. Troen The gonadotropin-suppressive activity of androgen is increased in elderly men Metabolism 33 1984 1052 1059
76. J.M. Wishart A.G. Need M. Horowitz Effect of age on bone density and bone turnover in men Clin Endocrinol 42 1995 141 146
77. B. Zumoff G.W. Strain J. Kream Age variation of the 24-hour mean plasma concentrations of androgens, estrogens, and gonadotropins in normal adult men J Clin Endocrinol Metab 54 1982 534 538