Molecular aspects of soluble guanylyl cyclase regulation

General Pharmacology: The Vascular System

Volumn 34, Issue 3, 2000, Pages 147-157

  Andreopoulos, Stavroula ^a   Papapetropoulos, Andreas ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Cyclic guanosine monophosphate (cGMP); Nitric oxide (NO); Soluble guanylyl cyclase (sGC)

Indexed keywords

CYCLIC GMP; GUANYLATE CYCLASE; MESSENGER RNA; NITRIC OXIDE;

ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME STRUCTURE, FUNCTION AND VARIABILITY; GENE EXPRESSION REGULATION; HUMAN; MAMMAL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; FORECASTING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENOME; GUANYLATE CYCLASE; HUMANS; PROTEIN CONFORMATION;

EID: 0033646732     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(00)00062-8     Document Type: Review

References (91)

1. Genetic mapping of soluble guanylyl cyclase genes: implications for linkage to blood pressure in the Dahl rat
2. Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression: role of enhanced vascular superoxide production
3. Generation and characterization of a stable soluble guanylate cyclase-overexpressing CHO cell line
4. 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein
5. 2 subunit of human guanylyl cyclase to chromosomal band 13q14.3 between markers D13S168 and D13S155
6. Expression of nitric oxide-sensitive guanylyl cyclase subunits in human corpus cavernosum
7. Pulmonary soluble guanylate cyclase, a nitric oxide receptor, is increased during the perinatal period
8. Tissue distribution of the human soluble guanylate cyclases
9. Expression of soluble guanylate cyclase activity requires both enzyme subunits
10. Characterization of the soluble guanylyl cyclase beta-subunit gene in the mosquito Anopheles gambiae
11. 2+/calmodulin
12. Loss of expression of the beta subunit of soluble guanylyl cyclase prevents nitric oxide-mediated inhibition of DNA synthesis in smooth muscle cells of old rats
13. Heterogeneity in human soluble guanylate cyclase due to alternative splicing
14. A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
15. Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation in the rat
16. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat
17. Mapping of a quantitative locus on rat chromosome 2
18. Genetic mapping of two new blood pressure quantitative loci in the rat by genotyping endothelin system genes
19. Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2
20. Resonance Raman characterization of soluble guanylate cyclase expressed from baculovirus
21. Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells
22. 1 subunits
23. Properties and mechanisms of production and action of endothelium-derived relaxing factor
24. Mechanisms of regulation and functions of guanylyl cyclases
25. Function of conserved cysteine residues on soluble guanylate cyclase
26. Soluble guanylate cyclase purified from bovine lung contains heme and copper
27. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain
28. 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33
29. The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide: potential relevance to regulation of blood pressure
30. 1 form of soluble guanylyl cyclase by nitric oxide: potential relevance to regulation of blood pressure
31. Expression of soluble guanylyl cyclase
32. Molecular cloning and expression of a new α subunit of soluble guanylyl cyclase
33. Soluble guanylate cyclase: the forgotten sibling
34. Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli
35. Purification of soluble guanylate cyclase from bovine lung by a new immunoaffinity chromatographic method
36. Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange: comparison of heme-containing and heme-deficient enzyme forms
37. Age-related changes of gene expression in mouse kidney: fluorescence differential display - PCR analyses
38. Soluble guanylate cyclase from rat lung exists as a heterodimer
39. Aging and chronic hypertension decrease expression of rat aortic soluble guanylyl cyclase
40. Soluble guanylyl cyclase: structure and regulation
41. Guanylyl cyclases, a growing family of signal-transducing enzymes
42. Sequence homologies between guanylyl cyclases and structural analogies to other signal-transducing proteins
43. Soluble guanylate cyclase in Saccharomyces cerevisiae
44. Cyclic cGMP and mechanisms of vasodilation
45. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension
46. Molecular characterization of two Drosophila guanylate cyclases expressed in the nervous system
47. Nerve growth factor decreases soluble guanylate cyclase in rat pheochromocytoma PC12 cells
48. Catalytic mechanism of the adenylyl and guanylyl cyclases: modeling and mutational analysis
49. 1 subunit genes
50. Molecular mechanisms and therapeutic strategies related to nitric oxide
51. Nitric oxide: physiology, pathophysiology and pharmacology
52. Molecular cloning of a cDNA coding for 70 kDa subunit of soluble guanylate cyclase from rat lung
53. Molecular cloning and expression of cDNAs coding for soluble guanylate cyclase from rat lung
54. Identification and characterization of a novel β subunit of soluble guanylyl cyclase that is active in the absence of a second subunit and is relatively insensitive to nitric oxide
55. Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme and protoporphyrin IX
56. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
57. Smooth muscle cell responsiveness in nitrovasodilators in hypertensive and normotensive rats
58. Regulation of vascular smooth muscle soluble guanylate cyclase activity, mRNA and protein levels by cAMP-elevating agents
59. Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1β
60. Mechanisms of tolerance to sodium nitroprusside in rat cultured aortic smooth muscle cells
61. Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP
62. 1 subunit of guanylate cyclase
63. Downregulation of soluble guanylyl cyclase in young and aging spontaneously hypertensive rats
64. Functional properties of a naturally occurring isoform of guanylyl cyclase
65. 1 subunits of the mammalian soluble guanyly cyclase genes
66. The expanding family of guanylyl cyclases
67. Escherichia coli lipopolysaccharide downregulates soluble guanylate cyclase in pulmonary artery smooth muscle
68. Two Drosophila genes that encode the alpha and beta subunits of the brain soluble guanylate cyclase
69. 1 subunit gene expression in RFL-6 rat fetal lung fibroblasts
70. The alpha1 subunit of soluble guanylyl cyclase is expressed in the rat brain
71. Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states
72. Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide
73. Complexity and diversity of mammalian adenylyl cyclases
74. Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases
75. The membrane form of guanylate cyclase. Homology with a subunit of the cytoplasmic form of the enzyme
76. Differential expression of mRNA for guanylyl cyclase-linked endothelium-derived relaxing factor receptor subunits in rat kidney
77. Homologous and heterologous desensitization of a guanylyl cyclase-linked nitric oxide receptor in cultured rat medullary interstitial cells
78. Physiological role of cGMP and cGMP-dependent protein kinase in the cardiovascular system
79. 1 subunit yields a nitric oxide insensitive form of soluble guanylate cyclase
80. Functional domains of soluble guanylyl cyclase
81. A functional chimera of mammalian guanylyl and adenylyl cyclases
82. Atrial natriuretic factor elicits on endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle
83. Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosylheme
84. 2 subunit of soluble guanylyl cyclase, to position 11q21-q22 on human chromosome 11
85. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors
86. A new form of guanylyl cyclase is preferentially expressed in rat kidney
87. Dominant negative mutants of nitric oxide-sensitive guanylyl cyclase
88. Human soluble guanylyl cyclase: functional expression and revised isoenzyme family
89. Homodimerization of soluble guanylyl cyclase subunits
90. Localization of the heme binding region in soluble guanylate cyclase
91. Long-term depression: a learning-related type of synaptic plasticity in the mammalian central nervous system