Expression of nitric oxide-sensitive guanylyl cyclase subunits in human corpus cavernosum

Biochemical Pharmacology

Volumn 59, Issue 6, 2000, Pages 713-717

  Behrends, Sönke ^a   Steenpass, Anna ^a   Porst, Hartmut ^b   Scholz, Hasso ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b Neuer Jungfernstieg 6a D 20354   (Germany)

Author keywords

Corpus cavernosum; Enzyme isoforms; Erectile dysfunction; Guanylyl cyclase; Nitric oxide

Indexed keywords

GUANYLATE CYCLASE; MESSENGER RNA; NITRIC OXIDE;

ARTICLE; CORPUS CAVERNOSUM; ENZYME SUBUNIT; ERECTILE DYSFUNCTION; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; GUANYLATE CYCLASE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; PENIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033954841     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00381-0     Document Type: Article

References (22)

1. Kerwin J.F. Jr, Lancaster J.R. Jr, Feldman P.F. Nitric oxide A new paradigm for second messengers . J Med Chem. 38:1995;4343-4362.
2. Burnett A.L. Nitric oxide in the penis Physiology and pathology . U Urol. 157:1997;320-324.
3. Melman A., Gingell J.C. The epidemiology and pathophysiology of erectile dysfunction. J Urol. 161:1999;5-11.
4. Ignarro J.L., Bush P.A., Buga G.M., Wood K.S., Fukuto J.M., Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun. 170:1990;843-850.
5. Holmquist F., Hedlund H., Andersson K.E. L-Ng-nitro arginine inhibits non-adrenergic, non-cholinergic relaxation of human isolated corpus cavernosum. Acta Physiol Scand. 141:1991;441-442.
6. Rajfer J., Aronson W.J., Bush P.A., Dorey F.J., Ignarro L.J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med. 326:1992;90-94.
7. Pickard R.S., Powell P.H., Zar M.A. Nitric oxide and cyclic GMP formation following relaxant nerve stimulation in isolated human corpus cavernosum. Br J Urol. 75:1995;516-522.
8. Ballard S., Gingell C.J., Tang K., Turner L.A., Price M.E., Naylor A.M. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol. 159:1998;2164-2171.
9. Owen J.A., Saunders F., Harris C. Topical nitroglycerin A potential treatment for impotence . J Urol. 141:1989;546-548.
10. Stief C.G., Holmquist F., Djamilian M., Krah H., Andersson K.E., Jonas U. Preliminary results with the nitric oxide donor linsidomine chlorhydrate in the treatment of human erectile dysfunction. J Urol. 148:1992;1437-1440.
11. 1 and the nitric oxide donor linsidomine for erectile failure A diagnostic comparative study of 40 patients . J Urol. 149:1993;1280-1283.
12. Truss M.C., Becker A.J., Djamilian M.H., Stief C.G., Jonas U. The role of the nitric oxide donor linisidomine chlorhydrate (SIN-1) in the diagnosis and treatment of erectile dysfunction. Urology. 44:1994;553-556.
13. Friebe A., Koesling D. Mechanism of YC-1-induced activation of soluble guanylyl cyclase. Mol Pharmacol. 53:1998;123-127.
14. Hobbs A.J. Soluble guanylyl cyclase The forgotten sibling . Trends Pharmacol Sci. 18:1997;484-491.
15. Zabel U., Weeger M., La M., Schmidt H.H. Human soluble guanylyl cyclase Functional expression and revised isoenzyme family . Biochem J. 335:1998;51-57.
16. Russwurm M., Behrends S., Harteneck C., Koesling D. Functional properties of a naturally occurring isoform of soluble guanylyl cyclase. Biochem J. 335:1998;125-130.
17. Yuen P.S., Potter L.R., Garbers D.L. A new form of guanylyl cyclase is preferentially expressed in rat kidney. Biochemistry. 29:1990;10872-10878.
18. 1 form of soluble guanylyl cyclase by nitric oxide. J Clin Invest. 100:1997;1488-1492.
19. Zabel U., Hausler C., Weeger M., Schmidt H.H. Homodimerization of soluble guanylyl cyclase subunits. Dimerization analysis using a glutathione s-transferase affinity tag. J Biol Chem. 274:1999;18149-18152.
20. 2 subunit of soluble guanylyl cyclase contains an insert homologous to a region within adenylyl cyclases and functions as a dominant negative protein. J Biol Chem. 270:1995;21109-21113.
21. 2 subunit of human guanylyl cyclase to chromosomal band 13q14.3 between markers D13S168 and D13S155. Genomics. 55:1999;126-127.
22. Friebe A., Wedel B., Harteneck C., Foerster J., Schultz G., Koesling D. Functions of conserved cysteines of soluble guanylyl cyclase. Biochemistry. 11:1997;1194-1198.