The induction of apoptosis and inhibition of AP-1 activity by TAC-101 (4-[3,5-bis(trimethylsilyl) benzamido] benzoic acid) may result in life prolonging effect in animals bearing metastasizing cancer

Anticancer Research

Volumn 20, Issue 5 B, 2000, Pages 3583-3590

  Shibata, J ^a   Murakami, K ^a   Aoyagi, Y ^a   Oie, S ^a   Hashimoto, A ^a   Suzuki, K ^a   Sano, M ^a   Wierzba, T T K ^a   Yamada, Y ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

AP 1; Apoptosis; Life prolonging effect; Liver metastasis; TAC 101

Indexed keywords

4 [3,5 BIS(TRIMETHYLSILYL)BENZAMIDO]BENZOIC ACID; DNA; TAC 101; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CELL MIGRATION; CONTROLLED STUDY; DNA DETERMINATION; DRUG INDUCED DISEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER METASTASIS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROGNOSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOATES; CELL DIVISION; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; STOMACH NEOPLASMS; TRANSCRIPTION FACTOR AP-1; TRIMETHYLSILYL COMPOUNDS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0033637688     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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