Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 279, Issue 6 42-6, 2000, Pages

  Benthem, Lambertus ^a,b   Keizer, Klaasjan ^a   Wiegman, Coen H ^a   De Boer, Sietse F ^a   Strubbe, Jan H ^a   Steffens, Anton B ^a   Kuipers, Folkert ^a   Scheurink, Anton J W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Hypothalamus pituitary adrenal axis; Insulin resistance; Sympathetic activity; Visceral obesity

Indexed keywords

LONG CHAIN FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; LIPID LIVER LEVEL; LIPID METABOLISM; LIPOLYSIS; LIVER METABOLISM; MEAN ARTERIAL PRESSURE; NONHUMAN; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; RAT; SYMPATHETIC TONE; SYNDROME X;

EID: 0033637174     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2000.279.6.e1286     Document Type: Article

References (58)

1. Overfeedig induced obesity in rats: Insulin sensitivity and autonomic regulation of metabolism
2. Abdominal obesity and risk
3. Portal adipose tissue as a generator of risk factors for cardiovascular disease and diabetes
4. Topics in type 2 diabetes
5. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
6. Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes
7. Mechanisms of fatty acid-induced inhibition of glucose uptake
8. Plasma catecholamines, corticosterone, and glucose responses to repeated stress in rats; effect of interstressor interval length
9. α-Adrenergic suppression of very-low-density-lipoprotein triacylglycerol secretion by isolated rat hepatocytes
10. Role of insulin and counter-regulatory hormones in the control of hepatic glycerolipid synthesis and low density lipoprotein catabolism in diabetes
11. High-performance liquid chromatographic (HPLC) separation and quantification of endogenous glucocorticoids after solid-phase extraction from plasma
12. Epinephrine-induced insulin resistance in man
13. Repeated blockade of mineralocorticoid receptors, but not of glucocorticoid receptors impairs food rewarded spatial learning
14. Fenofibrate modifies transaminase expression via peroxisome proliferator activated receptor alpha-dependent pathway
15. Enhanced sympathetic nervous system activity. The linchpin between insulin resistance, hyperinsulinemia, and heart rate
16. Effects of alcohal intake and obesity on serum liver enzyme activity in obese men with mild hypertension
17. Tumor necrosis factor-increased hepatic very-low-density lipoprotein production and increased serum triglyceride levels in diabetic rats
18. Insulin resistance and lipid metabolism
19. Hepatic nerve function
20. Mechanisms in the pressor effects of hepatic portal venous fatty acid infusion
21. Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension
22. Hyperinsulinemia, upper body adiposity and cardiovascular risk factors in non-diabetics
23. Co-variation of alanine aminotransferase levels with relative weight in blood donors
24. 3-adrenoceptor sensitivity in visceral adipose tissue
25. Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women
26. Central nervous system and peripheral abnormalities: Clues to the understanding of obesity and NIDDM
27. The deathly quartet
28. Insulin resistance in visceral obesity
29. Effects of oleate and fatty acids from omental adipocytes on insulin uptake in rat liver cells
30. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution
31. Amelioration of high-fat feeding-induced insulin resistance in skeletal muscle with the antiglucocorticoid RU486
32. Distribution of adipose tissue and risk of cardiovascular disease and death: A 12 year follow up of participants in the population study of women in Gothenburg, Sweden
33. Differential effects of eicosapentaenoic acid on glycerolipid and apolipoprotein B metabolism in primary human hepatocytes compared with HepG2 cells and primary rat hepatocytes
34. Intraportal infusion of 2, 5-anhydro-D-mannitol increases afferent activity in the common vagus branch
35. Serum alanine aminotransferase to aspartate aminotransferase ratio and degree of fatty liver in morbidly obese patients
36. Insulin resistance in Cushing's syndrome
37. Stimulation of afferent nerve terminals in the perfused rabbit liver by sodium salts of some long-chain fatty acids
38. Inducement by fat feeding of basal hyperglycemia in rats with abnormal β-cell function: Model for study of etiology and pathogenesis of NIDDM
39. Splanchnic insulin metabolism in obesity. Influence of body fat distribution
40. Prospective study of serum γ-glutamyltransferase and risk of NIDDM
41. Association between low birth-weight and high resting pulse in adult life: Is the sympathetic nervous system involved in programming the insulin resistance syndrome?
42. Role of insulin resistance in human disease
43. Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients
44. Cortisol-induced insulin resistance in man: Impaired suppression of glucose production and stimulation of glucose utilization due to a postreceptor defect of insulin action
45. Insulin and blood pressure during weight loss in obese adolescents
46. Adrenal and sympathetic catecholamines in exercising rats
47. Experience affects exercise-induced changes in catecholamines, glucose, and FFA
48. Endocrine and metabolic effects of experimental obesity in man
49. A computer-tomography based multicompartment body composition technique and anthropometric predictions of lean body mass, total and subcutaneous adipose tissue
50. Blood pressure and hormone changes associated with weight reduction in the obese
51. A method for frequent sampling of blood and continuous infusion of fluids in rats without disturbing the animal
52. Blood glucose and FFA levels in relation to the meal pattern in the normal rat and the ventromedial hypothalamic lesioned rat
53. Diabetes and cardiovascular disease. The 'common soil' hypothesis
54. Hepatic portal vein cannulation for infusion and blood sampling in freely moving rats
55. Relation of obesity and diet to sympathetic nervous system activity
56. Obesity, the sympathetic nervous system, and essential hypertension
57. Possible role for the glucose-fatty acid cycle in dexamethasone-induced insulin antagonism in rats
58. Dexamethasone induced impairment in skeletal muscle glucose transport is not reversed by inhibition of free fatty acid oxidation