Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women

International Journal of Obesity

Volumn 21, Issue 6, 1997, Pages 476-483

  Hollmann, M ^a   Runnebaum, B ^a   Gerhard, I ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Insulin resistance; Menstrual irregularity; Obesity; Waist hip ratio

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C PEPTIDE; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOPHYSIS HORMONE; INSULIN; LIPID; LIVER ENZYME; STEROID; TRIACYLGLYCEROL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD PRESSURE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONCEPTION; ENDOCRINE FUNCTION; FEMALE; FEMALE INFERTILITY; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MENSTRUAL IRREGULARITY; METABOLIC PARAMETERS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RISK; STEROID BLOOD LEVEL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

EID: 0030920031     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800433     Document Type: Article

References (48)

1. Caro JF. Insulin resistance in obese and nonobese man. J Clin Endocrinol Metab 1991; 73: 691-696.
2. Bergmann KE, Menzel R, Bergmann E, Tietze K, Stolzenberg H, Hoffmeister H. Verbreitung von Übergewicht in der erwachsenen Bevölkerung der Bundesrepublik Deutschland. Akt Ernährungsmed 1989; 14: 205-208.
3. Müller MJ, Lautz HU, von zur Mühlen A, Höllwarth I, Canzler H, Schmidt FW. Pathogenese und Therapie der Adipositas. Dtsch Med Wochenschr 1990; 115: 789-794.
4. Galvao-Teles A, Baptista F, DoCarmo I. Obesity and cancer. Mediographica 1991; 13: 16-18.
5. Hauner H, Ditschuneit HH, Pal SB, Pfeiffer EF. Fettgewebsverteilung und Adipositaskomplikationen bei übergewichtigen Frauen mit und ohne Hirsutismus. Dtsch Med Wochenschr 1987; 112: 709-713.
6. Kissebah AH, Vydelingum N, Murray R, Evans DJ, Hartz AJ, Kalkhoff RK, Adams PW. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1982; 54: 254-260.
7. Alexander JK. Cardiac structure and function in obesity. Mediographica 1991; 13: 9-12.
8. Glass AR. Endocrine aspects of obesity. Med Clin North Am 1989; 73: 139-160.
9. Hershcopf RJ, Bradlow HL. Obesity, diet, endogenous estrogens, and the risk of hormone-sensitive cancer. Am J Clin Nutr 1987; 45: 283-289.
10. Simonson DC. Hyperinsulinemia and its sequelae. Horm Metab Res Suppl 1990; 22: 17-25.
11. Forney JP, Milewich L, Chen GT, Garlock JL, Schwarz BE, Edman CD, MacDonald PC. Aromatization of androstendione to estrone by human adipose tissue in vitro. Correlation of adipose tissue mass, age, and endometrial neoplasia. J Clin Endocrinol Metab 1981; 53: 192-199.
12. Barbieri RL, Smith S, Ryan KJ. The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism. Fertil Steril 1988; 50: 197-212.
13. Evans DJ, Hoffmann RG, Kalkhoff RK, Kissebah AH. Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab 1983; 57: 304-310.
14. Haffner SM, Valdez RA, Stern MP, Katz MS. Obesity, body fat distribution and sex hormones in men. Int J Obes Relat Metab Disord 1993; 17: 643-649.
15. Harlass FE, Plymate SR, Fariss BL, Belts RP. Weight loss is associated with correction of gonadotropin and sex steroid abnormalities in the obese anovulatory female. Fertil Steril 1984; 42: 649-652.
16. Marin P, Kvist H, Lindstedt G, Sjostrom L, Bjorntorp P. Low concentrations of insulin like growth factor-1 in abdominal obesity. Int J Obes Relat Metab Disord 1993; 17: 83-89.
17. Sonnichsen AC, Ritter MM, Mohrle W, Richter WO, Schwandt P. The waist-to-hip ratio corrected for body mass index is related to serum triglycerides and high-density lipoprotein cholesterol but not to parameters of glucose metabolism in healthy premenopausal women. Clin Investig 1993; 71: 913-917.
18. Grenman S, Rönnemaa T, Irjala K, Kaihola HL, Grönroos M. Sex steroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: correlation with abdominal fat cell size and effect of weight reduction. J Clin Endocrinol Metab 1986; 63: 1257-1261.
19. Insler V, Shoham Z, Barash A, Koistinen R, Seppala M, Hen M, Lunenfeld B, Zadik Z. Polycystic ovaries in non-obese and obese patients: possible pathophysiological mechanism based on new interpretation of facts and findings. Hum Reprod 1993; 8: 379-384.
20. Nestler JE, Clore JN, Blackard WG. The central role of obesity (hyperinsulinema) in the pathogenesis of the polycystic ovary syndrome. Am J Obstet Gynecol 1989; 161: 1095-1097.
21. Tropeano G, Lucisano A, Liberale I, Barini A, Vuolo IP, Martino G, Menini E, Dell'Acqua S. Insulin, C-peptide, androgens, and beta-endorphin response to oral glucose in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 1994; 78: 305-309.
22. Zhang YW, Stern B, Rebar RW. Endocrine comparison of obese menstruating and amenorrheic women. J Clin Endocrinol Metab 1984; 58: 1077-1083.
23. Rich-Edwards JW, Goldman MB, Willett WC, Hunter DJ, Stampfer MJ, Colditz GA, Manson JA. Adolescent body mass index and infertility caused by ovulatory disorder. Am J Obstet Gynecol 1994; 171: 171-177.
24. Hartz AJ, Barboriak PN, Wong A, Katayama KP, Rimm AA. The association of obesity with infertility and related menstrual abnormalities in women. Int J Obes 1979; 3: 57-73.
25. Zaadstra BM, Seidell JC, Van Noord PAH, te Velde ER, Habbema JDF, Vrieswijk B, Karbaat J. Fat and female fecundity: prospective study of effect of body fat distribution on conception rates. BMJ 1993; 306: 484-487.
26. Crosignani PG, Ragni G, Parazzini F, Wyssling H, Lombroso G, Perotti L. Anthropometric indicators and response to gonadotrophin for ovulation induction. Hum Reprod 1994; 9: 420-423.
27. Galtrier-Dereure F, Montypeyroux F, Boulot P, Bringer J, Jaffiol C. Weight excess before pregnancy: complications and cost. Int J Obes 1995; 19: 443-448.
28. Yen SSC. The polycystic ovary syndrome. Clin Endocrinol 1980; 12: 177-208.
29. Hollmann M, Runnebaum B, Gerhard I. Effects of weight loss on the hormonal profile in obese, infertile women. Hum Reprod 1996; 11: 1884-1891.
30. Gerhard I, Reischmann T, Eggert-Kruse W, Runnebaum B. Untersuchung der Faktoren, die den Schwangerschaftseintritt und -ausgang durch medikamentöse Therapie bei sterilen Frauen beeinflussen. I. Anamnestische und klinische Parameter. Fertilität 1990; 6: 123-135.
31. Baien AH, Conway GS, Kaltsas G, Techatraisak K, Manning PJ, West C, Jacobs HS. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod 1995; 10: 2107-2111.
32. Herold G. Innere medizin. In: Herold G (ed). Innere Medizin. Köln, 1991, pp. 505-510
33. Immich H. Medizinische Statistik. Schattauer: Stuttgart, New York, 1974.
34. Dunaif A, Mandeli J, Fluhr H, Dobrjansky A. The impact of obesity and chronic hyperinsulinemia on gonadotropin release and gonadal steroid secretion in the polycystic ovary syndrome. J Clin Endocrinol Metab 1988; 66: 131-139.
35. Peiris AN, Struve MF, Kissebah AH. Relationship of body fat distribution to the metabolic clearance of insulin in premenopausal women. Int J Obes 1987; 11: 581-589.
36. Stout RW. Overview of the association between insulin and atherosclerosis. Metabolism 1985; 34: 7-12.
37. Foster DW. Insulin resistance - a secret killer. N Engl J Med 1989; 320: 733-734.
38. Every NR, Boyko EJ, Keane EM, Marshall JA, Rewers M, Hamman RF. Blood pressure, insulin, and C-peptide levels in San Luis Valley, Colorado. Diabetes Care 1993; 16: 1543-1550.
39. Pasquali R, Casimirri F. The impact of obesity on hyperandrogenisin and polycystic ovary syndrome in premenopausal women. Clin Endocrinol Oxf 1993; 39: 1-16.
40. Gerhard I, Postneek F. Möglichkeiten der Therapie durch Ohrakupunktur bei weiblicher Sterilität. Geburtsh u Frauenheilk 1988; 48: 165-171.
41. Gerhard I, Matthes J, Runnebaum B. The induction of ovulation with pulsatile gonadotrophin-releasing hormone (GnRH) administration in hyperandrogenic women after down-regulation with buserelin or suppression with an oral contraceptive. Hum Reprod 1993; 8: 2033-2038.
42. Poretsky L, Kalin MF. The gonadotropic function of insulin. Endocr Rev 1987; 8: 132-141.
43. Conway GS, Clark PM, Wong D. Hyperinsulinemia in the polycystic ovary syndrome confirmed with a specific immunoradiometric assay for insulin. Clin Endocrinol Oxf 1993; 38: 219-222.
44. Pasquali R, Casimirri F, Cantobelli S, Labate AM, Venturoli S, Paradisi R, Zannarini L. Insulin and androgen relationships with abdominal body fat distribution in women with and without hyperandrogenism. Horm Res 1993; 39: 179-187.
45. Peins AN, Mueller RA, Struve MF, Smith GA, Kissebah AH. Relationship of androgenic activity to splanchnic insulin metabolism and peripheral glucose utilization in premenopausal women. J Clin Endocrinol Metab 1987; 64: 162-169.
46. Hamilton-Fairley D, Kiddy D, Anyaoku V, Koistinen R, Seppala M, Franks S. Response of sex hormone binding globulin and insulin-like growth factor binding protein-1 to an oral glucose tolerance test in obese women with polycystic ovary syndrome before and after caloric restriction. Clin Endocrinol Oxf 1993; 39: 363-367.
47. Rajkhova M, Bicknell J, Jones M, Clayton RN. Insulin sensitivity in women with polycystic ovary syndrome: relationship to hyperandrogenemia. Fertil Steril 1994; 61: 605-612.
48. James WPT. Treatment of obesity and the quality of life. Mediographica 1991; 13: 19-22.