Heterogeneous fusion transcripts involving the NUP98 gene and HOXD13 gene activation in a case of acute myeloid leukemia with the t(2;11)(q31;p15) translocation

Leukemia

Volumn 14, Issue 9, 2000, Pages 1621-1629

  Arai, Y ^a   Kyo, T ^b   Miwa, H ^c   Arai, K ^a   Kamada, N ^d   Kita, K ^e   Ohki, M ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b ATOMIC BOMB SURVIVORS HOSPITAL   (Japan)

^c AICHI MEDICAL UNIVERSITY   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

^e MIE UNIVERSITY   (Japan)

Author keywords

FN1; Fusion gene; HOXD13; NUP98; T(2; 11)(q31; p15)

Indexed keywords

RNA HELICASE; DNA; HOMEODOMAIN PROTEIN; HOXD13 PROTEIN, HUMAN; MEMBRANE PROTEIN; NUCLEAR PORE COMPLEX PROTEIN 98; NUCLEAR PROTEIN; NUCLEOPORIN; RNA; RNA, RECOMBINANT; TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CASE REPORT; CHROMOSOME 11P; CHROMOSOME 2Q; CHROMOSOME BREAKAGE; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 2; DNA STRAND BREAKAGE; FUSION GENE; GENE ACTIVATION; GENE AMPLIFICATION; GENE DUPLICATION; GENE FUSION; GENE LOCUS; GENETIC LINKAGE; HUMAN; INTRON; LEUKEMOGENESIS; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RACE; RESTRICTION MAPPING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SOUTHERN BLOTTING; TRANSCRIPTION REGULATION; ACUTE DISEASE; ALTERNATIVE RNA SPLICING; CHROMOSOME 11; CHROMOSOME 2; GENE TRANSLOCATION; GENETICS; MIDDLE AGED; MOLECULAR CLONING; MOLECULAR GENETICS; MYELOID LEUKEMIA;

ACUTE DISEASE; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 2; CLONING, MOLECULAR; DNA, NEOPLASM; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA, MYELOID; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; RNA; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 0033623411     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401881     Document Type: Article

References (33)

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10. The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion
11. The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T cell acute lymphocytic leukemia
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14. Basic local alignment search tool
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18. EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is located at the 5' end of HOX4 locus on chromosome 2
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20. A common mechanism of chromosomal translocation in T and B cell neoplasia
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