Characterisation of NF-χB complexes in Theileria parva-transformed T cells

Microbes and Infection

Volumn 2, Issue 11, 2000, Pages 1311-1320

  Machado Jr , Joel ^a   Fernandez, Paula C ^a   Baumann, Ina ^b   Dobbelaere, Dirk A E ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

Parasite; Signalling pathway; Transcription factor

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN KAPPA CHAIN; PROTEIN C FOS; PROTEIN P50; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR RELB; UNCLASSIFIED DRUG; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; DNA BINDING PROTEIN; OLIGODEOXYRIBONUCLEOTIDE; ONCOPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL TRANSFORMATION; COMPLEX FORMATION; CROSS LINKING; DNA BINDING; ELECTROPHORETIC MOBILITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; T LYMPHOCYTE; THEILERIA PARVA; ACTIVE TRANSPORT; ANIMAL; CELL LINE; CELL NUCLEUS; CYTOLOGY; DIMERIZATION; GENETICS; LYMPHOCYTE ACTIVATION; METABOLISM; PARASITOLOGY; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; WESTERN BLOTTING;

ACTIVATING TRANSCRIPTION FACTOR 2; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIMERIZATION; DNA; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; LYMPHOCYTE ACTIVATION; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; OLIGODEOXYRIBONUCLEOTIDES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-REL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THEILERIA PARVA; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS; ULTRAVIOLET RAYS;

EID: 0033623297     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(00)01284-3     Document Type: Article

References (71)

1. Bovine T cell clones infected with Theileria parva produce a factor with IL 2-like activity
2. Theileria parva infection induces autocrine growth of bovine lymphocytes
3. Novel anti-malarial hydroxynaphthoquinones with potent broad spectrum anti-protozoal activity
4. Expression and characterization of the interleukin 2 receptor in Theileria parva-infected bovine lymphocytes
5. NF-χB and GTP cyclohydrolase regulate cytokine-induced nitric oxide production by cardiac myocytes
6. Constitutive IL-2 mRNA expression in lymphocytes, infected with the intracellular parasite Theileria parva
7. Expression of Tac antigen component of bovine interleukin-2 receptor in different leukocyte populations infected with Theileria parva or Theileria annulata
8. Transformation of leukocytes by Theileria parva and T. annulata
9. Transcriptional regulation of the IL-2 gene
10. Functionally distinct NF-χB binding sites in the immunoglobulin χ and IL-2 receptor α chain genes
11. The NF-χB and I χB proteins: New discoveries and insights
12. Structure, regulation and function of NF-χB
13. NF χB/I χB proteins. Their role in cell growth, differentiation and development
14. Activators and target genes of Rel/NF-χB transcription factors
15. Infection with the intracellular protozoan parasite Theileria parva induces constitutively high levels of NF-χB in bovine T lymphocytes
16. Parasite-mediated nuclear factor χB regulation in lymphoproliferation caused by Theileria parva infection
17. Function and activation of NF-χB in the immune system
18. Regulation of the NF-χB/rel transcription factor and IχB inhibitor system
19. Interaction of NF-χB and NFAT with the interferon-gamma promoter
20. Interaction between cell cycle regulator, E2F-1, and NF-χB mediates repression of HIV-1 gene transcription
21. Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-χB
22. The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression
23. Purification of a novel MHC class I element binding activity from thymus nuclear extracts reveals that thymic RBP-Jχ/CBF1 binds to NF-χB-like elements
24. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-χB/Rel transcription factors
25. A T cell nuclear factor resembling NF-AT binds to an NF-χB site and to the conserved lymphokine promoter sequence 'cytokine-1'
26. Flanking sequences for the human intercellular adhesion molecule-1 NF-χB response element are necessary for tumor necrosis factor α-induced gene expression
27. Aberrant rel/nfχb genes and activity in human cancer
28. The intracellular parasite Theileria parva protects infected T cells from apoptosis
29. N-acetylcysteine blocks apoptosis induced by N-α-tosyl-L-phenylalanine chloromethyl ketone in transformed T cells
30. UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein
31. Tumor necrosis factor α-induced E-selectin expression is activated by the nuclear factor-χB and c-Jun N-terminal kinase/p38 mitogen-activated protein kinase pathways
32. The inducible transcription activator NF-χB: Regulation by distinct protein subunits
33. Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production
34. χB binding activity in a murine macrophage-like cell line. Sequence-specific differences in χB binding and transcriptional activation functions
35. VLA-4 integrin cross-linking on human monocytic THP-1 cells induces tissue factor expression by a mechanism involving mitogen-activated protein kinase
36. Interleukin 2 transcription factors as molecular targets of cAMP inhibition: Delayed inhibition kinetics and combinatorial transcription roles
37. Induction of activator protein (AP)-1 and nuclear factor-χB by CD28 stimulation involves both phosphatidylinositol 3-kinase and acidic sphingomyelinase signals
38. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
39. Separation of oxidant-initiated and redox-regulated steps in the NF-χB signal transduction pathway
40. Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-χB
41. Possible role of nuclear factor-χB activity in germline C epsilon transcription in a human Burkitt lymphoma B cell line
42. Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-χB antagonists
43. The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-χB
44. Arachidonic acid influences proinflammatory gene induction by stabilizing the inhibitor-χBα/nuclear factor-χB (NF-χB) complex, thus suppressing the nuclear translocation of NF-χB
45. Distinct effects of rhioredoxin and antioxidants on the activation of transcription factors NF-χB and AP-1
46. A-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-χB activation induced by various inflammatory agents
47. Protein kinase C ε mediates lipopolysaccharide-induced nitric-oxide synthase expression in primary astrocytes
48. Evidence for a redox-sensitive protein tyrosine kinase in nuclear factor χB activation and interleukin 2 production in EL4. NOB1 cells
49. Activation of NF-χB by antineoplastic agents. Role of protein kinase C
50. Cytoskeletal control of gene expression: Depolymerization of microtubules activates NF-χB
51. Dithiocarbamates as potent inhibitors of nuclear factor χB activation in intact cells
52. Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor χB of HeLa cells. Interference in signalling by the proteinase inhibitors 3,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone
53. Novel inhibitors of cytokine-induced IχBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
54. Activation of NF-χB in vivo is regulated by multiple phosphorylations
55. Activation of nuclear factor-χB-dependent transcription by tumor necrosis factor-α is mediated through phosphorylation of Re1A/p65 on serine 529
56. RelB, a new Rel family transcription activator that can interact with p50-NF-χB
57. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
58. Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells
59. RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter
60. Differential DNA sequence specificity and regulation of HIV-1 enhancer activity by cRel-RelA transcription factor
61. Regulation of NF-χB activation by MAP kinase cascades
62. Signal transduction through NF-χB
63. Multiple signals converging on NF-χB
64. Activation of NF-χB by phosphatase inhibitors involves the phosphorylation of I χB α at phosphatase 2A-sensitive sites
65. Nuclear factor χB: An oxidative stress-responsive transcription factor of eukaryotic cells
66. Is NF-χB the sensor of oxidative stress?
67. Role of oxidants and antioxidants in the induction of AP-1, NF-χB, and glutathione S-transferase gene expression
68. H2O2 and antioxidants have opposite effects on activation of NF-χB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor
69. Reactive oxygen inter-mediates as apparently widely used messengers in the activation of the NF-χB transcription factor and HIV-1
70. Theileria parva: Taking control of host cell proliferation and survival mechanism