Cardiomyocyte gap junctions: A target of growth-promoting signaling

Trends in Cardiovascular Medicine

Volumn 8, Issue 4, 1998, Pages 180-187

  Kardami, Elissavet ^a,b   Doble, Bradley W ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; EPIDERMAL GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 2; GAP JUNCTION PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

CELL PROLIFERATION; CONTROLLED STUDY; GAP JUNCTION; GROWTH REGULATION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MEMBRANE BINDING; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0032076163     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(98)00007-3     Document Type: Review

References (44)

1. Angst BD, Khan LUR, Severs Net al. Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium. Circ Res. 80:1997;88-94.
2. Basilico C, Moscatelli D The FGF family of growth factors and oncogenes. Adv Cancer Res. 59:1992;115-165.
3. Beyer EC Gap junctions. Int Rev Cytol. 137C:1993;1-37.
4. Brand T, Schneider MD The TGFβ superfamily in myocardium: ligands, receptors, transduction, and function. J Mol Cell Cardiol. 27:1995;5-18.
5. Britz-Cunningham SH, Shah MM, Zuppan CW, Fletzer WH Mutations of the connexin43 gap junction gene in patients with heart malformations and defects of laterality. N Engl J Med. 332:1995;1323-1329.
6. Bruzzone R, White T, Paul DL Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem. 238:1996;1-27.
7. Cooklin M, Wallis WRJ, Sheridan DJ, Fry CH Changes in cell-to-cell electrical coupling associated with left ventricular hypertrophy. Circ Res. 80:1997;765-771.
8. Darrow BJ, Laing JG, Lampe PD, Saffitz JE, Beyer EC Expression of multiple connexins in cultured neonatal rat ventricular myocytes. Circ Res. 76:1995;381-387.
9. De Mello WC Gap junctional communication in excitable tissues: the heart as a paradigm. Prog Biophys Mol Biol. 61:1994;1-35.
10. Doble BW, Kardami E: 1997. FGF-2 stimulates connexin43 phosphorylation and decreased metabolic coupling of cardiomyocytes via PKC- but not MAPK-dependent signaling [abst]. Circulation 96:I-495.
11. Doble BW, Bosc D, Litchfield D, Kardami E Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circ Res. 79:1996;647-658.
12. Fishman GI, Hertzberg EL, Spray DC, Leinwand L Expression of connexin43 in the developing rat heart. Circ Res. 68:1991;782-787.
13. Godwin AJ, Green LM, Walsh MP, McDonald JR, Walsh DA, Fletcher WH In situ regulation of cell-cell communication by the cAMP-dependent protein kinase and protein kinase C. Mol Cell Biochem. 127 128:1993;293-307.
14. Goodenough DA, Goliger JA, Paul DL Connexins, connexons and intercellular communication. Annu Rev Biochem. 65:1996;475-502.
15. Hossain MZ, Sawchuk MA, Murphy LJ, Hetzberg EL, Nagy JI Kainic acid induced alterations in antibody recognition of connexin-43 and loss of astrocytic gap junctions in rat brain. Gila. 10:1994;250-265.
16. Kardami E Stimulation and inhibition of cardiac myocyte proliferation in vitro. Mol Cell Biochem. 92:1990;129-135.
17. Kardami E, Stoski RM, Doble BW, Yamamoto T, Herzberg EL, Nagy JI: 1991. Biochemical and ultrastructural evidence for the association of basic fibroblast growth factor with cardiac gap junctions. J. Biol Chem 266:19,551-19,557.
18. Kardami E, Padua RR, Pasumarthi KBS, et al.: 1993. Basic fibroblast growth factor in cardiac myocytes: expression and effects. In Cummins P, ed. Growth Factors and the Cardiovascular System. Boston, Kluwer Academic Publishers, pp 55-76.
19. Kardami E, Liu L, Padua RRet al. Regulation of bFGF and FGF receptors in the heart. Ann NY Acad Sci. 752:1995;353-369.
20. Kwak BR, van Veen TAB, Analbers LJS, Jongsma HJ TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels. Exp Cell Res. 220:1995;456-463.
21. Lau AF, Hatch-Pigot V, Crow DS Evidence that heart connexin43 is a phospho-protein. J Mol Cell Cardiol. 23:1991;6659-6663.
22. Lau AF, Kanemitsu MY, Kurata WE, Danesh S, Boynton AL Epidermal growth factor disrupts gap junctional communication and induces phosphorylation of connexin43 on serine. Mol Biol Cell. 3:1992;865-874.
23. Liu L, Padua RR, Mesaeli Het al. Adult cardiac myocytes express functional basic fibroblast growth factor receptors. Am J Physiol. 268:1995;H1927-H1938.
24. Liu S, Taffet S, Stoner Let al. A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxy tail length. Biophys J. 64:1993;1422-1433.
25. Maldonado PE, Rose B, Lowenstein WR Growth factors modulate junctional cell-to-cell communication. J Membr Biol. 106:1988;203-210.
26. Mikalsen S-O, Husoy T, Vikhamar G, Sanner T Induction of phosphotyrosine in the gap junction protein connexin43. FEBS Lett. 401:1997;271-275.
27. Moreno AP, Saez JC, Fishman GI, Spray DC Human connexin43 gap junction channels: regulation of unitary conductance by phosphorylation. Circ Res. 74:1995;1050-1057.
28. Nishida E, Gotoh Y The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci. 18:1993;128-130.
29. Padua RR, Fandrich RR, Kardami E Increased basic fibroblast growth factor accumulation and distinct patterns of localization in isoproterenol-induced cardiomyocyte injury. Growth Factors. 8:1993;291-306.
30. Padua RR, Sethi R, Davey-Forgie SE, et al.: 1996. Cardioprotection and basic fibroblast growth factor. In Dhalla NS, Singal PK, Beamish RE, eds. Pathophysiology of Heart Failure. Boston, Kluwer Academic Publishers, pp 501-518.
31. Parker TG, Schneider MD Growth factors, proto-oncogenes and plasticity of the cardiac phenotype. Ann Rev Physiol. 53:1991;179-200.
32. Peters NS, Green CR, Poole-Wilson PA, Severs NJ Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation. 88:1993;864-875.
33. Peters NS, Coromillas J, Severs NJ, Wit AL Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation. 95:1997;988-996.
34. Puceat M, Vassort G Signaling by protein kinase C isoforms in the heart. Mol Cell Biochem. 157:1996;65-72.
35. Saffitz JE, Hoyt RH, Luke RA, Kanter HL, Beyer EC Cardiac myocyte interconnections at gap junctions: role in normal and abnormal electrical conduction. Trends Cardiovasc Med. 2:1992;56-60.
36. Sanderson MJ, Charles AC, Boitano S, Dirksen ER Mechanisms and function of intercellular calcium signaling. Mol Cell Endocrinol. 98:1994;173-187.
37. Spach MS Changes in the topology of gap junctions as an adaptive structural response of the myocardium. Circulation. 90:1994;1103-1106.
38. Spray DC: 1994. Physiological and pharmacological regulation of gap junction channels. In Citi S, ed. Molecular Mechanisms of Epithelial Cell Junctions: From Development to Disease. Austin, TX, RG Landes Co, pp 195-215.
39. Valiunas V, Bukauskas FF, Weingart R Conductance and selective permeability of connexin43 gap junction channels examined in neonatal rat heart cells. Circ Res. 80:1997;708-719.
40. Veenstra RD, Wang H-Z, Beblo D-Het al. Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res. 77:1995;1156-1165.
41. Verheule S, van Kempen MJA, te Welscher PHJA, Kwak BR, Jongsma HJ Characterization of gap junction channels in adult rabbit atrial and ventricular myocardium. Circ Res. 80:1997;673-681.
42. Wang H-Z, Veenstra RD Monovalent cation and anion selectivity sequences of the rat connexin43 gap junction channel. J Gen Physiol. 109:1997;491-507.
43. Warn-Cramer BJ, Lampe PD, Kurata WEet al. Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem. 271:1996;3779-3786.
44. Yamasaki H, Naus CCG Role of connexin genes in growth control. Carcinogenesis. 17:1996;1199-1213.