Human herpes virus 8 (KSHV) contamination of peripheral blood and autograft products from multiple myeloma patients

Bone Marrow Transplantation

Volumn 25, Issue 2, 2000, Pages 153-160

  Vescio, R A ^a   Wu, C H ^a   Zheng, L ^a   Sheen, D ⁿ   Ma, H ^a   Liu, J ^a   Stewart, A K ^b   Ballester, O ^c   Noga, S J ^d   Rugo, H ^e   Freytes, C ^f   Stadtmauer, E ^g   Sahebi, F ^h   Tarantolo, S ⁱ   Stiff, P ^j   Schiller, G J ^a   White, M ^k   Jacobs, C ^k   Dipersio, J ^l   Anderson, K C ^m   Berenson, J R ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h KAISER PERMANENTE   (United States)

ⁱ UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

^j LOYOLA UNIVERSITY CHICAGO   (United States)

^k Cell Pro Inc   (United States)

^l WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m DANA FARBER CANCER INSTITUTE   (United States)

ⁿ University of California Los Angeles ^*

more..

Author keywords

Autologous transplantation; Human herpesvirus 8; Kaposi's sarcoma associated herpesvirus; Leukapheresis; Multiple myeloma; Pathogenesis

Indexed keywords

CD34 ANTIGEN; VIRUS DNA;

ARTICLE; AUTOGRAFT; CONTAMINATION; DENDRITIC CELL; HUMAN; HUMAN HERPESVIRUS 8; LEUKAPHERESIS; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; MULTIPLE MYELOMA; PATHOGENESIS; PRIORITY JOURNAL; BLOOD; BLOOD AUTOTRANSFUSION; BONE MARROW PURGING; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOLOGY; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPES VIRUS INFECTION; ISOLATION AND PURIFICATION; METHODOLOGY; MOLECULAR GENETICS; MULTICENTER STUDY; NUCLEOTIDE SEQUENCE; PHASE 3 CLINICAL TRIAL; POLYMERASE CHAIN REACTION; RANDOMIZED CONTROLLED TRIAL; STEM CELL MOBILIZATION; SURVIVAL RATE; TREATMENT OUTCOME; VIROLOGY; VIRUS LOAD;

ANTIGENS, CD34; BASE SEQUENCE; BLOOD TRANSFUSION, AUTOLOGOUS; BONE MARROW PURGING; COHORT STUDIES; DENDRITIC CELLS; DNA, VIRAL; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HUMANS; LEUKAPHERESIS; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA; MULTIPLE MYELOMA; POLYMERASE CHAIN REACTION; SURVIVAL RATE; TREATMENT OUTCOME; VIRAL LOAD;

EID: 0033621555     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1702113     Document Type: Article

References (45)

1. Alexanian R, Dimopoulous M: The treatment of multiple myeloma. New Engl J Med 1994; 330: 484-489.
2. Attal M, Harousseau JL, Stoppa AM et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma patients. New Engl J Med 1996; 335: 91-97.
3. Fermand JP, Chevret S, Ravaud P et al. High-dose chemoradiotherapy and autologous blood stem cell transplantation in multiple myeloma: results of a phase II trial involving 63 patients. Blood 1993; 82: 2005-2009.
4. Vesole DH, Tricot G, Jagannath S et al. Autotransplant in multiple myeloma: what have we learned? Blood 1996; 8: 838-847.
5. Schiller G, Vescio R, Freytes C et al. Autologous CD34-selecled blood progenitor cell transplants for patients with advanced multiple myeloma. Bone Marrow Transplant 1998; 21: 141-145.
6. Lemoli RM, Fortuna A, Raspadori D et al. Selection and transplantation of autologous hematopoietic CD34+ cells for patients with multiple myeloma. Leuk Lymphoma 1997; 26 (Suppl. 1): 1-11.
7. Alegre A, Diaz-Mediavilla J, San-Miguel J et al. Autologous peripheral blood stem cell transplantation for multiple myeloma: a report of 259 cases from the Spanish Registry. Spanish Registry for Transplant in MM (Grupo Español de Trasplante Hematopoyetico-GETH) and PETHEMA. Bone Marrow Transplant 1998; 21: 133-140.
8. Goldschmidt H, Hegenbart U, Wallmeier M et al. High-dose therapy with peripheral blood progenitor cell transplantation in multiple myeloma. Ann Oncol 1997; 8: 243-246.
9. Beral V, Peterman T, Berkelman R, Jaffe HW. Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 1990; 335: 123-128.
10. Chang Y, Cesarman E, Pessin MS et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994; 266: 1865-1869.
11. Moore P, Boshoff C, Weiss R, Chang Y. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 1996; 274: 1739-1744.
12. Burger R, Neipel F, Fleckenstein B et al. Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells. Blood 1998; 91: 1858-1863.
13. Cesarman E, Chang Y, Moore PS et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. New Engl J Mud 1995; 332: 1186-1191.
14. Soulier J, Grollet L, Oksenhendler E et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995; 86: 1276-1280.
15. Rettig MB, Ma HJ, Vescio RA et al. Kaposi's sarcoma-associated Herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science 1997: 276: 1851-1854.
16. Rettig M, Vescio R, Moss T et al. Detection of Kaposi's sarcoma-associated herpesvirus in the peripheral blood of multiple myeloma patients. Blood 1997; 90 (Suppl. 1): 587a.
17. Lyman SD. Biologic effects and potential clinical applications of Flt3 ligand. Curr Opin Hematol 1998; 5: 192-196.
18. Durie BGM, Salmon SE. A clinical staging system for multiple myeloma: correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 1975; 36: 842-854.
19. Asou H, Said JW, Yang R et al. Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells. Blood 1998; 91: 2475-2481.
20. Kaplan EL, Meier P. Nonparametric estimations from incomplete observations. J Am Stat Assoc 1958; 53: 457.
21. Ma H, Vescio R, Der Danielian M et al. The HHV-8 IL-8R homologue and interferon regulatory factor genes are frequently expressed in myeloma bone marrow biopsies whereas the vIL-6 is rarely found. Blood 1998; 92 (Suppl. 1): 515a.
22. Said JW, Rettig MR, Heppner K et al. Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma. Blood 1997; 90: 4278-4282.
23. Mosialos G, Birkenbach M, Ayehunie S et al. Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Am J Pathol 1996; 148: 593-600.
24. Zhou LJ, Tedder TF. Human blood dendritic cells selectively express CD83. a member of the immunoglobulin superfamily. J Immunol 1995; 154: 3821-3835.
25. Pinkus GS, Pinkus JL, Langhoff E et al. Fascin: a sensitive new marker for Reed-Sternberg cells of Hodgkin's disease -evidence for a dendritic or B-cell derivation? Am J Pathol 1997; 150: 543-562.
26. Dubois B, Vanbervliet B, Fayette J et al. Dendritic cells enhance growth and differentiation of CD40-activated B lymphocytes. J Exp Med 1997; 185: 941-945.
27. Vescio R, Schiller G, Stewart AK et al. Multicenter phase III trial to evaluate CD34+ selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma. Blood 1999; 93: 1858-1868.
28. Tarte K, Olsen SJ, Lu YZ et al. Clinical-grade functional dendritic cells from patients with multiple myeloma are not infected with Kuposi's sarcoma-associated herpesvirus. Blood 1998; 91: 1852-1857.
29. Chauhan D, Bharti A, Raje N et al. Detection of Kupusi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells. Blood 1999; 93: 1482-1486.
30. Raje N, Gong J, Chauhan D et al. Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences. Blood 1999; 93: 1487-1495.
31. Bouscary D, Dupin N, Fichelson S et al. Lack of evidence of an association between HHV-8 and multiple myeloma. Leukemia 1998; 12: 1840-1841.
32. Olsen S, Tarte K, Sherman W et al. Evidence against KSHV infection in the pathogenesis of multiple myeloma. Virus Res 1998; 57: 197-202.
33. Mitterer M, Mair W, Gatti D et al. Dendritic cells derived from bone marrow and CD34+ selected blood progenitor cells of myeloma patients, cultured in serum-free media, do not contain the Kaposi sarcoma herpesvirus genome. Br J Haematol 1998; 102: 1338-1340.
34. Cull GM, Carter GI, Timms JM et al. Low incidence of human herpesvirus 8 in stem cell collections from myeloma patients. Bone Marrow Transplant 1999; 23: 759-761.
35. Tarte K, Olsen SJ, Rossi JF et al. Kaposi's sarcoma-associated herpesvirus is not detected with immunosuppression in multiple myeloma. Blood 1998; 92: 2186-2188.
36. Bellos F, Cremer FW, Ehrbrecht E et al. Leukapheresis cells of patients with multiple myeloma collected after mobilization with chemotherapy and G-CSF do not bear Kaposi's sarcoma associated herpesvirus DNA. Br J Haematol 1998; 103: 1192-1197.
37. Tisdale JF, Stewart AK, Dickstein B et al. Human herpesvirus 8 in patients with multiple myeloma. Blood 1997; 90 (Suppl. 1): 588a.
38. Yi Q, Ekman M, Anton D et al. Blood dendritic cells from myeloma patients are not infected with Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8). Blood 1998; 92: 402-404.
39. Tarte K, Chang Y, Klein B. Kaposi's sarcoma associated herpesvirus and multiple myeloma: lack of criteria for causality. Blood 1999; 93: 3159-3162.
40. Rettig M, Vescio R, Ma H et al. Sequence variability of HHV-8 from the dendritic cells of multiple myeloma patients. Blood 1997; 90 (Suppl. 1): 86a.
41. Zong JC, Metroka C, Reitz MS et al. Strain variability among Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: evidence that a large cohort of United States AIDS patients may have been infected by a single common isolate. J Virol 1997; 71: 2505-2511.
42. Foreman KE, Friborg J. Kong W et al. Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. New Engl J Med 1997; 336: 163-171.
43. Foreman KE, Alkan S, Krueger AE et al. Geographically distinct HHV-8 DNA sequences in Saudi Arabian iatrogenic Kaposi's sarcoma lesions. Am J Pathol 1998; 153: 1001-1004.
44. Tisdale JF, Stweart AK, Dickstein B et al. Molecular and serological examination of the relationship of human herpesvirus 8 to multiple myeloma: orf 26 sequences in bone marrow stroma are not restricted to myeloma patients and other regions of the genome are not detected. Blood 1998; 92: 2681-2687.
45. Neipel F, Albrecht JC, Fleckenstein B. Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity? J Virol 1997: 71: 4187-4192.