Dendritic cells derived from bone marrow and CD34+ selected blood progenitor cells of myeloma patients, cultured in serum-free media, do not contain the Kaposi sarcoma herpesvirus genome

British Journal of Haematology

Volumn 102, Issue 5, 1998, Pages 1338-1340

  Mitterer, M ^a,d   Mair, W ^a   Gatti, D ^a   Sheldon, J ^b   Vachula, M ^c   Coser, P ^a   Schultz, T F ^b  

^a Department of Haematology   (Italy)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c BAXTER HEALTHCARE CORPORATION   (United States)

^d Dept Haematol Bone Marrow T ^*  (Italy)

Author keywords

Dendritic cells; Immunotherapy; Kaposi sarcoma associated herpesvirus; Multiple myeloma; Peripheral blood progenitor cells

Indexed keywords

CD34 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BONE MARROW CELL; CASE REPORT; CHILD; DENDRITIC CELL; HEMATOPOIETIC STEM CELL; HERPES VIRUS; HUMAN; HUMAN CELL; KAPOSI SARCOMA; MULTIPLE MYELOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS GENOME;

ANTIGENS, CD34; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DENDRITIC CELLS; GENOME, VIRAL; HERPESVIRUS 8, HUMAN; HUMANS; MULTIPLE MYELOMA; STEM CELLS;

EID: 0031667020     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00894.x     Document Type: Article

References (12)

1. + haematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells. Journal of Experimental Medicine, 185, 341-349.
2. Gao, S.J., Kingsley, L., Li, M., Zheng, W., Paravicini, C., Ziegler, J., Newton, R., Rinaldo, C.R., Saah, A., Phair, J., Detels, R., Chang, Y. & Moore, P.S. (1996) KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nature Medicine, 8, 925-928.
3. Gartner, S. & Kaplan, H.S. (1980) Long-term culture of human bone marrow cells. Proceedings of the National Academy of Sciences of the United States of America, 77, 4756-4759.
4. Gluckman, J.C., Canque, B., Chapuis, F. & Rosenzwaig, M. (1997) In vitro generation of human dendritic cells and cell therapy, Cytokines, Cellular and Molecular Therapy, 3, 187-196.
5. Guery, J.C. & Adorini, L. (1995) Dendritic cells are the most efficient in presenting endogenous naturally processed sell epitopes to class II retricted T-cells. Journal of Immunology, 154, 536-544.
6. MacKenzie, J., Sheldon, J., Morgan, G., Cook, G., Schultz, T.F. & Jarrett, R.F. (1997) HHV8 and multiple myeloma in UK. Lancet, 350, 1144-1145.
7. Marcelin, A.G., Dupin, N., Bouscary, D., Bossi, P., Cacoub, P., Ravaud, P. & Calvez, V. (1997) HHV8 and multiple myeloma in France. Lancet, 350, 1144.
8. Rettig, M.B., Ma, H.J., Vescio, R.A., Pold, M., Schiller, G., Belson, D., Savage, A., Nishikubo, C., Wu, C., Fraser, J., Said, J.W. & Berenson, J.R. (1997) Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients. Science, 276, 1851-1854.
9. Simpson, G.R., Schultz, T.F., Whitby, D., Cook, P.M., Boshoff, C., Rainbow, L., Howard, M.R., Gao, S.J., Bohenzky, R.A., Simmonds, P., Lee, C., de Ruiter, A., Hatzakis, A., Tedder, R.S., Weiler, I.V., Weiss, R.A. & Moore, P.S. (1996) Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet, 348, 1133-1138.
10. + cells in the blood of patients with multiple myeloma express CD19 and IgH m RNA and have patient specific IgH VDJ gene rearrangements. Blood, 89, 1824-1833.
11. Tarte, K., Olsen, S.J., Lu, X.Y., Legouffe, E., Rossi, J.F., Chang, Y. & Klein, B. (1998) Clinical grade functional dendritic cells from patients with multiple myeloma are not infected with Kaposi's sarcoma associated herpesvirus. Blood, 91, 1852-1857.
12. Tasaka, T. Said, J.W., Morosetti, R., Park, D., Vereek, W., Nagai, M., Takahara, J. & Koeffler, H.P. (1997) Is Kaposi sarcoma-associaled herpesvirus ubiquitous in urogenital and prostate tissue? Blood, 89, 1686-1689.