Effect of nonpolar substitutions of the conserved Phe11 in the fusion peptide of HIV-1 gp41 on its function, structure, and organization in membranes

Biochemistry

Volumn 38, Issue 35, 1999, Pages 11359-11371

  Pritsker, Moshe ^a   Rucker, Joseph ^b   Hoffman, Trevor L ^b   Doms, Robert W ^b   Shai, Yechiel ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 41; HYBRID PROTEIN; PHENYLALANINE; PHOSPHOLIPID; PROTEIN SUBUNIT; VALINE;

AMINO TERMINAL SEQUENCE; ARTICLE; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; MEMBRANE FUSION; NONHUMAN; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; VIRUS ENVELOPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL FUSION; CELL LINE; CONSERVED SEQUENCE; ENDOPEPTIDASE K; GENES, REPORTER; GLYCINE; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; HYDROLYSIS; MEMBRANE FUSION; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PHENYLALANINE; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; SOLUTIONS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE; VIRAL FUSION PROTEINS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0033621026     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990232e     Document Type: Article

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