Mutational analysis of the fusion peptide of the human immunodeficiency virus type 1: Identification of critical glycine residues

Virology

Volumn 218, Issue 1, 1996, Pages 94-102

  Delahunty, Martha D ^a   Rhee, Ina ^a   Freed, Eric O ^b   Bonifacino, Juan S ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; VIRUS GLYCOPROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; VIRUS ADSORPTION; VIRUS CELL INTERACTION;

EID: 0029968695     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1996.0169     Document Type: Article

References (47)

1. Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Willey, R., Rabson, A., and Martin, M. A. (1986). Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59, 284-291.
2. Blobel, C. P., Wolfsberg, T. G., Turck, C. W., Myles, D. G., Primakoff, P., and White, J. M. (1992). A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion. Nature 356, 248-252.
3. Bosch, M. L., Earl, P. L., Fargnoli, K., Picciafuoco, S., Giombini, F., Wong, S. F., and Franchini, G. (1989). Identification of the fusion peptide of primate immunodeficiency viruses. Science 244, 694-697.
4. Brasseur, R., Lorge, P., Goormaghtigh, E., Ruysschaert, J. M., Espion, D., and Burny, A. (1988). The mode of insertion of the paramyxovirus F1 N-terminus into lipid matrix, an initial step in host cell/virus fusion. Virus Genes 1, 325-332.
5. Broder, C. C., Dimitrov, D. S., Blumenthal, R, and Berger, E. A. (1993). The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s). Virology 193, 483-491.
6. Cosson, P., and Bonifacino, J. S. (1992). Role of transmembrane domain interactions in the assembly of class II MHC molecules. Science 258, 659-662.
7. Dalgleish, A. G., Beverley, P. C., Clapham, P. R., Crawford, D. H., Greaves, M. F., and Weiss, R. A. (1984). The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312, 763-767.
8. Earl, P. L., Broder, C. C., Long, D., Lee, S. A., Peterson, J., Chakrabarti, S., Doms, R. W., and Moss, B. (1994). Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol. 68, 3015-3026.
9. Epand, R. M., Cheetham, J. J., Epand, R. F., Yeagle, P. L., Richardson, C. D., Rockwell, A., and Degrado, W. F. (1992). Peptide models for the membrane destabilizing actions of viral fusion proteins. Biopolymers 32, 309-314.
10. Felser, J. M., Klimkait, T., and Silver, J. (1989). A syncytia assay for human immunodeficiency virus type I (HIV-I) envelope protein and its use in studying HIV-I mutations. Virology 170, 566-570.
11. Freed, E. O., Delwart, E. L., Buchschacher, G. L., Panganiban, J., and Panganiban, A. J. (1992). A mutation in the human immunodeficiency type I transmembrane glycoprotein 41 dominantly interferes with fusion and infectivity. Proc. Natl. Acad. Sci. USA 89, 70-74.
12. Freed, E. O., and Martin, M. A. (1994). Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120. J. Virol. 68, 2503-2512.
13. Freed, E. O., and Martin, M. A. (1995). The role of human immunodeficiency virus type 1 envelope glycoproteins in virus infection. J. Biol. Chem. 270, 23883-23886.
14. Freed, E. O., Myers, D. J., and Risser, R. (1989). Mutational analysis of the cleavage sequence of the human immunodeficiency virus type I envelope protein precursor gp160. J. Virol. 63, 4670-4675.
15. Freed, E. O., Myers, D. J., and Risser, R. (1990). Characterization of the fusion domain of the human immunodeficiency virus type 1 envelope glycoprotein gp41. Proc. Natl. Acad. Sci. USA 87, 4650-4654.
16. Freed, E. O., and Risser, R. (1987). The role of envelope glycoprotein processing in murine leukemia virus infection. J. Virol. 61, 2852-2856.
17. Gallaher, W. R. (1987). Detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus. Cell 50, 327-328.
18. Gallaher, W. R., Segrest, J. P., and Hunter, E. (1992). Are fusion peptides really sided insertional helices? Cell 70, 531-532.
19. Graham, F. L., and van der Eb, A. J. (1973). A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467.
20. Guy, H. R., Durell, S. R., Schoch, C., and Blumenthal, R. (1992). Analyzing the fusion process of influenza hemagglutinin by mutagenesis and molecular modeling. Biophys. J. 62, 95-97.
21. Henderson, L. A., and Qureshi, M. N. (1993). A peptide inhibitor of human immunodeficiency virus infection binds to novel human cell surface polypeptides. J. Biol. Chem. 268, 15291-15297.
22. Horth, M., Lambrecht, B., Khim, M. C. L., Bex, F., Thiriart, C., Ruysschaert, J. M., Burny, A., and Brasseur, R. (1991). Theoretical and functional analysis of the SIV fusion peptide. EMBO J. 10, 2747-2755.
23. Horvath, C. M., and Lamb, R. A. (1992). Studies on the fusion peptide of a paramyxovirus fusion glycoprotein: Roles of conserved residues in cell fusion J. Virol. 66, 2443-2455.
24. Klatzmann, D., Champagne, E., Chamaret, S., Gruest, J., Guetard, D., Hercend, T., Gluckman, J. C., and Montagnier, L. (1984). T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312, 767-768.
25. Kowalski, M., Potz, J., Basiripour, L., Dorfman, T., Goh, W. C., Terwilliger, E., Dayton, A., Rosen, C., Haseltine, W., and Sodroski, J. (1987). Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. Science 237, 1351-1355.
26. Lasky, L. A., Nakamura, G., Smith, J. H., Fennie, C., Shimosaki, L., Patzer, E., Berman, P., Gregory, T., and Capon, D. J. (1987). Delineation of a region of the human immunodeficiency virus type 1 (HIV-1) gp120 glycoprotein critical for interaction with the CD4 receptor. Cell 50, 975-985.
27. Lemmon, M. A., Flanagan, J. M., Hunt, J. F., Adair, B. D., Bormann, B. J., Dempsey, C. E., and Engelman, D. M. (1992a). Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices. J. Biol. Chem. 267, 7683-7689.
28. Lemmon, M. A., Flanagan, J. M., Treutlein, H. R., Zhang, J., and Engelman, D. M. (1992b). Sequence specificity in the dimerization of transmembrane alpha-helices. Biochemistry 31, 12719-12725.
29. Li, S. C., and Deber, C. M. (1994). A measure of helical propensity for amino acids in membrane environments. Struct. Biol. 1, 368-373.
30. Lifson, J. D., Feinberg, M. B., Reyes, G. R., Rabin, L., Banapour, B., Chakrabarti, S., Moss, B., Wong-Staal, F., Steimer, K. S., and Engleman, E. G. (1986). Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein. Nature 323, 725-728.
31. Maddon, P. J., Dagleish, A. G., McDougal, J. S., Clapman, P. R., Weiss, R. A., and Axel, R. (1986). The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47, 333-348.
32. Martin, I., Defrise, Q. F., Mandieau, V., Nielsen, N. M., Saermark, T., Burny, A., Brasseur, R., Ruysschaert, J. M., and Vandenbranden, M. (1991). Fusogenic activity of SIV (simian immunodeficiency virus) peptides located in the GP32 NH2 terminal domain. Biochem. Biophys. Res. Commun. 175, 872-879.
33. McCune, J. M., Rabin, L. B., Feinberg, M. B., Lieberman, M., Kosek, J. C., Reyes, G. R., and Weissman, I. L. (1988). Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus. Cell 53, 55-67.
34. Myers, G. (1988). In "Human Retroviruses and AIDS 1988" (G. Myers et al., Eds.), p. 68.
35. Nieva, J. L., Nir, S., Muga, A., Goñi, F. M., and Wilschut, J. (1994). Interaction of the HIV-1 fusion peptide with phospholipid vesicles: Different structural requirements for fusion and leakage. Biochemistry 33, 3201-3209.
36. Pantaleo, G., Poli, G., Butini, L., Fox, C., Dayton, A. I., and Fauci, A. S. (1991). Dissociation between syncytia formation and HIV spreading. Suppression of syncytia formation does not necessarily reflect inhibition of HIV infection. Eur. J. Immunol. 21, 1771-1774.
37. Rafalski, M., Lear, J. D., and Degrado, W. F. (1990). Phospholipid interactions of synthetic peptides representing the N-terminus of HIV gp41. Biochemistry 29, 7917-7922.
38. Rusche, J. R., Javaherian, K., McDanal, C., Petro, J., Lynn, D. L., Grimaila, R., Langlois, A., Gallo, R. C., Arthur, L. O., Fischinger, P. J., Bolognesi, D. P., Putney, S. D., and Matthews, T. J. (1988). Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120. Proc. Natl. Acad. Sci. USA 85, 3198-3202.
39. Schneider, J., Kaaden, O., Copeland, T. D., Oroszlan, S., and Hunsmann, G. (1986). Shedding and interspecies type sero-reactivity of the envelope glycoprotein gp120 of the human immunodeficiency virus. J Gen. Virol. 67, 2533-2538.
40. Sodroski, J., Goh, W. C., Rosen, C., Campbell, K., and Haseltine, W. A. (1986). Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature 322, 470-474.
41. Stein, B. S., Gowda, S. D., Lifson, J. D., Penhallow, R. C., Bensch, K. G., and Engleman, E. G. (1987). pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane. Cell 49, 659-668.
42. Sullivan, N., Thali, M., Furman, C., Ho, D. D., and Sodroski, J. (1993). Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type I gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody. J. Virol. 67, 3674-3679.
43. Tersmette, M., De Goede, G. R., Al, B. J., Winkel, I. N., Gruters, R. A., Cuypers, H. T., Huisman, H. G., and Miedema, F. (1988). Differential syncytium-inducing capacity of human immunodeficiency virus isolates: Frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. J. Virol. 62, 2026-2032.
44. White, J. M. (1990). Viral and cellular membrane fusion proteins. Annu. Rev. Physiol. 52, 675-697.
45. White, J. M. (1992). Membrane fusion. Science 258, 917-924.
46. Willey, R. L., Bonifacino, J. S., Potts, B. J., Martin, M. A., and Klausner, R. D. (1988). Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160. Proc. Natl. Acad. Sci. USA 85, 9580-9584.
47. Willey, R. L., Maldarelli, F., Martin, M. A., and Strebel, K. (1992). Human Immunodeficiency virus type I vpu protein regulates the formation of intracellular gp160-CD4 complexes. J. Virol. 66, 226-234.